Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Liron Bar-Peled"'
Autor:
Nadia Rasheed, Tatiani B. Lima, Gustavo F. Mercaldi, Andrey F.Z. Nascimento, Ana L.S. Silva, Germanna L. Righetto, Liron Bar‐Peled, Kuang Shen, David M. Sabatini, Fabio C. Gozzo, Ricardo Aparicio, Juliana H.C. Smetana
Publikováno v:
FEBS Open Bio, Vol 9, Iss 9, Pp 1589-1602 (2019)
Ragulator is a pentamer composed of p18, MP1, p14, C7orf59, and hepatitis B virus X‐interacting protein (HBXIP; LAMTOR 1—5) which acts as a lysosomal scaffold of the Rag GTPases in the amino acid sensitive branch of TORC1 signaling. Here, we pres
Externí odkaz:
https://doaj.org/article/105087508ad54b549ac83eec6ccc124e
Autor:
Gregory M Solis, Rozina Kardakaris, Elizabeth R Valentine, Liron Bar-Peled, Alice L Chen, Megan M Blewett, Mark A McCormick, James R Williamson, Brian Kennedy, Benjamin F Cravatt, Michael Petrascheck
Publikováno v:
eLife, Vol 7 (2018)
Aging impairs the activation of stress signaling pathways (SSPs), preventing the induction of longevity mechanisms late in life. Here, we show that the antibiotic minocycline increases lifespan and reduces protein aggregation even in old, SSP-deficie
Externí odkaz:
https://doaj.org/article/8d48aceb33a9430d85b333a85f0d70bb
Publikováno v:
Cell Reports, Vol 12, Iss 9, Pp 1445-1455 (2015)
mTORC1 controls key processes that regulate cell growth, including mRNA translation, ribosome biogenesis, and autophagy. Environmental amino acids activate mTORC1 by promoting its recruitment to the cytosolic surface of the lysosome, where its kinase
Externí odkaz:
https://doaj.org/article/3ac0e0cefb034548967e7acda8ed0c87
Autor:
Lynne Chantranupong, Rachel L. Wolfson, Jose M. Orozco, Robert A. Saxton, Sonia M. Scaria, Liron Bar-Peled, Eric Spooner, Marta Isasa, Steven P. Gygi, David M. Sabatini
Publikováno v:
Cell Reports, Vol 9, Iss 1, Pp 1-8 (2014)
Summary: The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a major regulator of cell growth that responds to numerous environmental cues. A key input is amino acids, which act through the heterodimeric Rag GTPases (RagA or RagB bound t
Externí odkaz:
https://doaj.org/article/c9bca710a90f4b2a84f1d20f8fd2edb3
Autor:
Liron Bar-Peled, Nora Kory
Publikováno v:
Nat Metab
Metabolism has historically been studied at the levels of whole cells, whole tissues and whole organisms. As a result, our understanding of how compartmentalization-the spatial and temporal separation of pathways and components-shapes organismal meta
Autor:
Ryan B. Corcoran, Rebecca S. Heist, Aaron N. Hata, Liron Bar-Peled, Giulia Siravegna, Jochen K. Lennerz, Samuel J. Klempner, Justin F. Gainor, Dejan Juric, Islam Baiev, Mustafa Sakhi, Katerina A. Fella, Mohammed U. Syed, Alexa G. Michel, Lesli A. Kiedrowski, Junbing Zhang, Meagan B. Ryan, Chendi Li, Jessica J. Lin, Noritaka Tanaka
Mutant-selective KRASG12C inhibitors, such as MRTX849 (adagrasib) and AMG 510 (sotorasib), have demonstrated efficacy in KRASG12C-mutant cancers, including non–small cell lung cancer (NSCLC). However, mechanisms underlying clinical acquired resista
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b6aa2acd4b997a9e54783ae8dd826d4
https://doi.org/10.1158/2159-8290.c.6549266
https://doi.org/10.1158/2159-8290.c.6549266
Autor:
Ryan B. Corcoran, Rebecca S. Heist, Aaron N. Hata, Liron Bar-Peled, Giulia Siravegna, Jochen K. Lennerz, Samuel J. Klempner, Justin F. Gainor, Dejan Juric, Islam Baiev, Mustafa Sakhi, Katerina A. Fella, Mohammed U. Syed, Alexa G. Michel, Lesli A. Kiedrowski, Junbing Zhang, Meagan B. Ryan, Chendi Li, Jessica J. Lin, Noritaka Tanaka
Supplementary Materials
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0a96c09e6d29bcd6766cf1adc0dadec
https://doi.org/10.1158/2159-8290.22540040.v1
https://doi.org/10.1158/2159-8290.22540040.v1
Autor:
Junbing Zhang, Claire M. Simpson, Jacqueline Berner, Harrison B. Chong, Jiafeng Fang, Zehra Ordulu, Tommy Weiss-Sadan, Anthony P. Possemato, Stefan Harry, Mariko Takahashi, Tzu-yi Yang, Marianne Richter, Himani Patel, Abby E. Smith, Alexander D. Carlin, Adriaan F. Hubertus de Groot, Konstantin Wolf, Lei Shi, Ting-Yu Wei, Benedikt R. Dürr, Nicholas J. Chen, Tristan Vornbäumen, Nina O. Wichmann, Mohammed S. Mahamdeh, Venkatesh Pooladanda, Yusuke Matoba, Shaan Kumar, Eugene Kim, Sara Bouberhan, Esther Oliva, Bo R. Rueda, Roy J. Soberman, Nabeel Bardeesy, Brian B. Liau, Michael Lawrence, Matt P. Stokes, Sean A. Beausoleil, Liron Bar-Peled
Publikováno v:
Cell. 186:2361-2379.e25
Autor:
Liron, Bar-Peled, Dudley W, Lamming
Publikováno v:
Cell research.
Autor:
Tommy Weiss-Sadan, Maolin Ge, Addriaan de Groot, Alexander Carlin, Magdy Gohar, Hannah Fischer, Lei Shi, Ting-Yu Wei, Charles H. Adelmann, Tristan Vornbäumen, Benedkit R. Dürr, Mariko Takahashi, Marianne Richter, Junbing Zhang, Tzu-Yi Yang, Vindhya Vijay, Makiko Hayashi, David E. Fischer, Aaron N. Hata, Thales Papaginanakopoulos, Raul Mostoslavsky, Nabeel Bardeesy, Liron Bar-Peled
Multiple cancers regulate oxidative stress by activating the transcription factor NRF2 through mutation of its negative regulator KEAP1. NRF2 has been studied extensively in KEAP1-mutant cancers, however the role of this pathway in cancers with wildt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e6bca0f03c908f5891a12becbd18f540
https://doi.org/10.1101/2022.08.31.506025
https://doi.org/10.1101/2022.08.31.506025