Can machine learning bring cardiovascular risk assessment to the next level? A methodological study using FOURIER trial data

Autor: Mikhail Zaslavskiy, Armando Lira Pineda, David Dellamonica, Adrien Rousset, Robert P. Giugliano, Marc S. Sabatine, Romuald Menuet, Paul Trichelair, L. Ricci

Publikováno v: European Heart Journal - Digital Health. 3:38-48

Aims Through this proof of concept, we studied the potential added value of machine learning (ML) methods in building cardiovascular risk scores from structured data and the conditions under which they outperform linear statistical models. Methods an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::edc544d6e87a812b559c90119d2213f7
https://doi.org/10.1093/ehjdh/ztab093

BENEFITS OF ICOSAPENT ETHYL IN PATIENTS WITH RECENT ACUTE CORONARY SYNDROME (ACS): REDUCE-IT ACS

Autor: Philippe Gabriel Steg, Deepak L. Bhatt, Michael Miller, Eliot A. Brinton, Terry A. Jacobson, Steven Ketchum, Lixia Jiao, Armando Lira Pineda, Ralph T. Doyle, Jean Claude Tardif, Christie M. Ballantyne

Publikováno v: Journal of the American College of Cardiology. 81:1113

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1227c0bc8616816115c45839c22a12a0
https://doi.org/10.1016/s0735-1097(23)01557-7

Predicting Benefit From Evolocumab Therapy in Patients With Atherosclerotic Disease Using a Genetic Risk Score Results From the FOURIER Trial

Autor: Marc S. Sabatine, Huei Wang, Terje R. Pedersen, Frederick K. Kamanu, Anthony C Keech, Yared Gurmu, Francesco Nordio, Nicholas A Marston, Steven A. Lubitz, Carolina Roselli, Christian T. Ruff, Robert P. Giugliano, Patrick T. Ellinor, Peter S. Sever, Armando Lira Pineda

Publikováno v: Circulation
Circulation, 141(8), 616-623. LIPPINCOTT WILLIAMS & WILKINS

Background: The ability of a genetic risk score to predict risk in established cardiovascular disease and identify individuals who derive greater benefit from PCSK9 (proprotein convertase subtilisin/kexin type 9) inhibition has not been established.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2f8378591ab7953ca243556eb546e04e
https://research.rug.nl/en/publications/16493d87-1a00-4924-9cd8-d27605935d89

Correction

Autor: Prakash Deedwania, David M. Charytan, Scott M. Wasserman, Terje R. Pedersen, Robert Giugliano, Anders G. Olsson, J-G Park, Sabatine, Anthony Keech, Peter S. Sever, Armando Lira Pineda

Publikováno v: Journal of the American College of Cardiology. 74:1162-1166

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7bd79d5f16f5026607a3ffa866cd32bd
https://doi.org/10.1016/j.jacc.2019.06.041

Lipoprotein(a), PCSK9 Inhibition, and Cardiovascular Risk Insights From the FOURIER Trial

Autor: Henrik Jensen, Kyung Ah Im, Anthony C Keech, Kurt Huber, Erik S.G. Stroes, S. Lale Tokgozoglu, François Mach, Ioanna Gouni-Berthold, Terje R. Pedersen, J. Wouter Jukema, Robert P. Giugliano, Marat V. Ezhov, Michelle L. O'Donoghue, Richard Ceska, Marc S. Sabatine, Estella Kanevsky, Peter S. Sever, Armando Lira Pineda, Sergio Fazio, Scott M. Wasserman

Publikováno v: Circulation, 139(12), 1483-1492. LIPPINCOTT WILLIAMS & WILKINS
O'Donoghue, M L, Fazio, S, Giugliano, R P, Stroes, E S G, Kanevsky, E, Gouni-Berthold, I, Im, K, Lira Pineda, A, Wasserman, S M, Češka, R, Ezhov, M V, Jukema, J W, Jensen, H K, Tokgözoğlu, S L, Mach, F, Huber, K, Sever, P S, Keech, A C, Pedersen, T R & Sabatine, M S 2019, ' Lipoprotein(a), PCSK9 Inhibition and Cardiovascular Risk : Insights from the FOURIER Trial ', Circulation, vol. 139, no. 12, pp. 1483-1492 . https://doi.org/10.1161/CIRCULATIONAHA.118.037184

Background: Lipoprotein(a) [Lp(a)] may play a causal role in atherosclerosis. PCSK9 (proprotein convertase subtilisin/kexin 9) inhibitors have been shown to significantly reduce plasma Lp(a) concentration. However, the relationship between Lp(a) leve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::42877639160f694bf5a712afceb264a5
http://hdl.handle.net/1887/122115