Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Liqiong Ou"'
Autor:
Jinchun Wu, Yang Liu, Liqiong Ou, Tingting Gan, Zhengrong Zhangding, Shaopeng Yuan, Xinyi Liu, Mengzhu Liu, Jiasheng Li, Jianhang Yin, Changchang Xin, Ye Tian, Jiazhi Hu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Mitochondria serve as the cellular powerhouse, and their distinct DNA makes them a prospective target for gene editing to treat genetic disorders. However, the impact of genome editing on mitochondrial DNA (mtDNA) stability remains a mystery
Externí odkaz:
https://doaj.org/article/381b32eb86f24fcf9a522190b64ea5c1
Autor:
Jianhang Yin, Kailun Fang, Yanxia Gao, Liqiong Ou, Shaopeng Yuan, Changchang Xin, Weiwei Wu, Wei-wei Wu, Jiaxu Hong, Hui Yang, Jiazhi Hu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-8 (2022)
Undesired chromosomal translocations, vector integrations, and large deletions remain a problem for therapeutic gene editing in vivo. Here, the authors compare the CRISPR-Cas9TX variant with CRISPR-Cas9 and show elimination of chromosomal translocati
Externí odkaz:
https://doaj.org/article/ead978410b604a268f507033d862566f
Autor:
Changchang Xin, Jianhang Yin, Shaopeng Yuan, Liqiong Ou, Mengzhu Liu, Weiwei Zhang, Jiazhi Hu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
CRISPR-Cas12f nucleases can be effectively packaged into AAVs for gene therapy, but a systematic evaluation of editing outcomes is lacking. Here the authors perform a comprehensive assessment of 4 Cas12f proteins and compare to Cas9 and two Cas12a pr
Externí odkaz:
https://doaj.org/article/332dbab4ca354529bd6a1326a36a0303
Autor:
Lingyi Fu, Weng Lao, I., Liyun Huang, Liqiong Ou, Lei Yuan, Ziteng Li, Shuo Li, Wanming Hu, Shaoyan Xi
Publikováno v:
American Journal of Surgical Pathology; Nov2024, Vol. 48 Issue 11, p1372-1380, 9p