Genome-wide aggregated trans-effects on risk of type 1 diabetes: A test of the “omnigenic” sparse effector hypothesis of complex trait genetics

Autor: Iakovliev, Andrii, McGurnaghan, Stuart J., Hayward, Caroline, Colombo, Marco, Lipschutz, Debby, Spiliopoulou, Athina, Colhoun, Helen M., McKeigue, Paul M.

Publikováno v: In The American Journal of Human Genetics 1 June 2023 110(6):913-926

Genetics of C-peptide and Age at Diagnosis in Type 1 Diabetes.

Autor: Roshandel D; Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Canada., Spiliopoulou A; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK.; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., McGurnaghan SJ; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Iakovliev A; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Lipschutz D; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Hayward C; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK., Bull SB; Lunenfeld-Tanenbaum Research Institute, Sinai Health, Toronto, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada., Klein BEK; School of Medicine and Public Health, Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, US., Lee KE; School of Medicine and Public Health, Department of Ophthalmology and Visual Sciences, University of Wisconsin, Madison, US., Kinney GL; Department of Epidemiology, Colorado School of Public Health, University of Colorado, Aurora, USA., Rewers M; Barbara Davis Center for Diabetes, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, USA., Costacou T; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., Miller RG; Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA., McKeigue PM; Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK., Paterson AD; Genetics and Genome Biology Program, The Hospital for Sick Children, Toronto, Canada.; Dalla Lana School of Public Health, University of Toronto, Toronto, Canada., Colhoun HM; Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.

Publikováno v: Diabetes [Diabetes] 2024 Nov 18. Date of Electronic Publication: 2024 Nov 18.