In Vitro Experimental Model of Trained Innate Immunity in Human Primary Monocytes

Autor: Siroon Bekkering, Bastiaan A. Blok, Leo A. B. Joosten, Niels P. Riksen, Reinout van Crevel, Mihai G. Netea

Publikováno v: Clinical and Vaccine Immunology, 23, 926-933
Clinical and vaccine immunology, 23(12), 926-933. American Society for Microbiology
Bekkering, S, Blok, B A, Joosten, L A B, Riksen, N P, van Crevel, R & Netea, M G 2016, ' In Vitro experimental model of trained innate immunity in human primary monocytes ', Clinical and Vaccine Immunology (Online), vol. 23, no. 12, pp. 926-933 . https://doi.org/10.1128/CVI.00349-16
Clinical and Vaccine Immunology, 23, 12, pp. 926-933
Clinical and Vaccine Immunology

Innate immune memory, or trained immunity, has recently been described to be an important property of cells of the innate immune system. Due to the increased interest in this important new field of immunological investigation, we sought to determine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ec80a74fa770d3f40278253b746fa69
https://hdl.handle.net/2066/172784

Sumoylation coordinates the repression of inflammatory and anti-viral gene-expression programs during innate sensing

Autor: Aymeric Silvin, Pierre-Emmanuel Joubert, Jacob-Sebastian Seeler, Ido Amit, Joao G. Magalhaes, Nicolas Manel, Jack-Christophe Cossec, Anne Dejean, Adrien Decque, Olivier Joffre, Ronnie Blecher-Gonen, Sebastian Amigorena, Pierre Lapaquette, Matthew L. Albert

Publikováno v: Nature Immunology
Nature Immunology, 2016, 17 (2), pp.140-149. ⟨10.1038/ni.3342⟩
Nature Immunology, Nature Publishing Group, 2016, 17 (2), pp.140-149. ⟨10.1038/ni.3342⟩

International audience; Innate sensing of pathogens initiates inflammatory cytokine responses that need to be tightly controlled. We found here that after engagement of Toll-like receptors (TLRs) in myeloid cells, deficient sumoylation caused increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::082a2423966ca06422f4633b1d591ca6
https://hal-pasteur.archives-ouvertes.fr/pasteur-01380657

The Proinflammatory Cytokine Response to Chlamydia trachomatis Elementary Bodies in Human Macrophages Is Partly Mediated by a Lipoprotein, the Macrophage Infectivity Potentiator, through TLR2/TLR1/TLR6 and CD14

Autor: Tsukasa Seya, Madeleine Vuillet, Laurence Anne Neff, Ursula Spenato, Sylvette Bas, Misako Matsumoto, Cem Gabay

Publikováno v: Journal of Immunology, Vol. 180, No 2 (2008) pp. 1158-68

Chlamydiae components and signaling pathway(s) responsible for the production of proinflammatory cytokines by human monocytes/macrophages are not clearly identified. To this aim, Chlamydia trachomatis-inactivated elementary bodies (EB) as well as the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb5113c6719d78f708397351095d479
https://doi.org/10.4049/jimmunol.180.2.1158

Metabolic-cytokine responses to a second immunological challenge with LPS in mice withT. gondiiinfection

Autor: Hernan R. Chang, Lucien Girardier, Irène Garcia, Rudolf Lucas, Abdul G. Dulloo, Denis Arsenijevic, Jean-Claude Pechère, Josiane Seydoux

Publikováno v: American Journal of Physiology, Vol. 274, No 3 Pt 1 (1998) pp. E439-445
Europe PubMed Central
Scopus-Elsevier

Injection of 10 cysts of Toxoplasma gondii (Me49 strain) into Swiss Webster mice results in 1) an acute phase of infection lasting for 2–3 wk, characterized by weight loss, and 2) a chronic phase in which surviving mice show either partial weight r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef32e928840ad6703164ad07dc39586e
https://doi.org/10.1152/ajpendo.1998.274.3.e439

Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength

Autor: Anton J. M. de Craen, Diana van Heemst, P.E. Slagboom, Karel G M Beenakker, Rudi G. J. Westendorp, Andrea B. Maier

Publikováno v: Aging Cell, 12(4), 682-689. Wiley-Blackwell
Beenakker, K G M, Westendorp, R G J, de Craen, A J M, Slagboom, P E, van Heemst, D & Maier, A B 2013, ' Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength ', Aging Cell, vol. 12, no. 4, pp. 682-9 . https://doi.org/10.1111/acel.12095
Aging Cell, 12(4), 682-9. Wiley-Blackwell
Beenakker, K G M, Westendorp, R G J, Craen, A J M, Slagboom, P E, van Heemst, D & Maier, A B 2013, ' Pro-inflammatory capacity of classically activated monocytes relates positively to muscle mass and strength ', Aging Cell, vol. 12, no. 4, pp. 682-689 . https://doi.org/10.1111/acel.12095
Aging Cell, 12(4), 682-9

In mice, monocytes that exhibit a pro-inflammatory profile enter muscle tissue after muscle injury and are crucial for clearance of necrotic tissue and stimulation of muscle progenitor cell proliferation and differentiation. The aim of this study was

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::058a8a7f0145c755e624c2e2f61fb7ae
https://hdl.handle.net/1887/88345