Effect of immunosuppressive drugs on cytokine production in canine whole blood stimulated with lipopolysaccharide or a combination of ionomycin and phorbol 12‐myristate 13‐acetate

Autor: Lakshmi Narayanan, Simon M. Firestone, Todd M. Archer, Caroline S Mansfield, Julien R.S. Dandrieux

Publikováno v: Dandrieux, J R S, Narayanan, L, Firestone, S, Archer, T M & Mansfield, C S 2019, ' Effect of immunosuppressive drugs on cytokine production in canine whole blood stimulated with lipopolysaccharide or a combination of ionomycin and phorbol 12-myristate 13-acetate ', Veterinary Medicine and Science, vol. 5, no. 2, pp. 199-205 . https://doi.org/10.1002/vms3.143
Veterinary Medicine and Science

A pharmacodynamic assay has been previously developed to monitor ciclosporin treatment in dogs by assessing inhibition of cytokine transcription after whole blood stimulation with 12‐myristate 13‐1 acetate and ionomycin (PMA/I). In this study, wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f05bee1d1ba6bdd4b8933ab4e8f82b9e
https://doi.org/10.1002/vms3.143

Microglia lacking a peroxisomal β-oxidation enzyme chronically alter their inflammatory profile without evoking neuronal and behavioral deficits

Autor: Philip Van Damme, Lien Beckers, Stijn Stroobants, Sander Beel, Ivana Geric, Myriam Baes, Rudi D'Hooge

Publikováno v: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-15 (2019)
Journal of Neuroinflammation

Background Microglia play a central role in most neurological disorders, but the impact of microgliosis on brain environment and clinical functions is not fully understood. Mice lacking multifunctional protein-2 (MFP2), a pivotal enzyme in peroxisoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::956cabd117a620008453a8c092f71205
https://doi.org/10.1186/s12974-019-1442-3

Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia

Autor: Aline Rideau Batista Novais, Nadia Soussi-Yanicostas, Olivier Baud, Jérôme Mairesse, Pierre Gressens, Rahma Hassan-Abdi, Stefania Maccari, Daniel Vaiman, Manuela Zinni, Julien Pansiot, Mickael Tanter, Marina Colella, Charlie Demene, Christiane Charriaut-Marlangue

Publikováno v: Glia
Glia, Wiley, 2019, 67 (2), pp.345-359. ⟨10.1002/glia.23546⟩
Glia, 2019, 67 (2), pp.345-359. ⟨10.1002/glia.23546⟩
Glia, Vol. 67, No 2 (2019) pp. 345-359

International audience; Abstract Prematurity and fetal growth restriction (FGR) are frequent conditions associated with adverse neurocognitive outcomes. We have previously identified early deregulation of genes controlling neuroinflammation as a puta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::246001b075e8521e159943553296593c
https://pubmed.ncbi.nlm.nih.gov/30506969

Evaluation of anti-proliferative and anti-inflammatory activities of Pelagia noctiluca venom in Lipopolysaccharide/Interferon-γ stimulated RAW264.7 macrophages

Autor: Rabiaa M. Sghaier, Yosra Ayed, Dhafer Laouini, Hassen Bacha

Publikováno v: Biomedicine and Pharmacotherapy
Biomedicine and Pharmacotherapy, Elsevier Masson, 2016, 84, pp.1986-1991. 〈10.1016/j.biopha.2016.11.010 〉
Biomedicine and Pharmacotherapy, Elsevier Masson, 2016, 84, pp.1986-1991. ⟨10.1016/j.biopha.2016.11.010⟩

International audience; Components of Pelagia noctiluca (P. noctiluca) venom were evaluated for their anticancer and nitric Oxide (NO) inhibition activities. Three fractions, out of four, obtained by gel filtration on Sephadex G75 of P. noctiluca ven

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bf245dbc45e5a060c082c657154154d
https://hal-riip.archives-ouvertes.fr/pasteur-01455071

Pivotal role of M-DC8+ monocytes from viremic HIV-infected patients in TNFα overproduction in response to microbial products

Autor: Nipa Decroix, Anne Hosmalin, Jean-Pierre Jourdain, Anne-Sophie Liovat, Odile Launay, Christiane Deveau, Michaela Müller-Trutwin, Matthieu Goguet, Charles-Antoine Dutertre, Sonia Amraoui, Pierre Loulergue, Laurence Meyer, Vincent Feuillet, Séverine A. Degrelle, Annalisa DeRosa, Cécile Goujard, Yolande Richard, Lene Vimeux

Publikováno v: Blood
Blood, American Society of Hematology, 2012, 120 (11), pp.2259-2268. ⟨10.1182/blood-2012-03-418681⟩
Blood, 2012, 120 (11), pp.2259-2268. ⟨10.1182/blood-2012-03-418681⟩

HIV infects activated CD4+ T cells and induces their depletion. Progressive HIV infection leading to AIDS is fueled by chronic immune hyperactivation, mediated by inflammatory cytokines like TNFα. This has been related to intestinal epithelial damag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5fb5a4137f647010c8abf343dbc7b070
https://doi.org/10.1182/blood-2012-03-418681