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Redox-sensitive lipophilic prodrugs: delivering unstable chemotherapeutant for improved cancer therapy

Autor: Fu Li, Zhao Huang, Huitong Chen, Lu Yan, Jin Li, Yue Su, Qian Zhang, Zhengye Huang, Yaxin Zheng

Publikováno v: Drug Delivery, Vol 26, Iss 1, Pp 1068-1079 (2019)

Therapeutic application of unmodified camptothecin (CPT) is severely restricted by its extremely low water solubility and the instability of active lactone ring. In this study, a redox-sensitive CPT-OA conjugate containing the disulfide bond (CPT-SS-

Externí odkaz: https://doaj.org/article/3d816ee987734b9a8bd7d09c280f6a42

Near infrared fluorogenic probe as a prodrug model for evaluating cargo release by nanoemulsions

Autor: Mayeul Collot, Nicolas Anton, Sophie Bou, Andrey S. Klymchenko, Xinyue Wang

Publikováno v: Journal of Materials Chemistry B: Materials for Biology and Medicine
Journal of Materials Chemistry B: Materials for Biology and Medicine, 2020, 8 (27), pp.5938-5944. ⟨10.1039/d0tb00783h⟩
Journal of Materials Chemistry B
Journal of Materials Chemistry B: Materials for Biology and Medicine, Royal Society of Chemistry, 2020, 8 (27), pp.5938-5944. ⟨10.1039/d0tb00783h⟩

International audience; Nanoemulsions (NEs) are biocompatible and stealth nanodroplets that can efficiently encapsulate hydrophobic cytoactive drugs in their oily core. NEs were shown to accumulate in tumors by enhanced permeability and retention (EP

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::823b0e7f34c64546a42e54726a7b4691
https://doi.org/10.1039/d0tb00783h

Modular Engineering of Targeted Dual-Drug Nanoassemblies for Cancer Chemoimmunotherapy

Autor: Meimei Xiong, Meijuan Huang, Yong Wang, Maling Gou, Shuai Wang, Ling Yang, Tianyi Kang, Jiao Zhu, Jinlu Liu, Yang Li, Yulan Huang, Xiawei Wei

Publikováno v: ACS Applied Materials & Interfaces. 11:36371-36382

Combination of chemotherapeutics and immunomodulators can generate synergistic anticancer efficacy, exerting efficient chemoimmunotherapy for cancer treatment. Nanoparticulate delivery systems hold great promise to promote synergistic anticancer effi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1f40f39ccf7d5e04277703d880924e9
https://doi.org/10.1021/acsami.9b11881

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