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Akademický článek

Mechanism-Driven Metabolic Engineering for Bio-Based Production of Free R-Lipoic Acid in Saccharomyces cerevisiae Mitochondria

Autor: Binbin Chen, Jee Loon Foo, Hua Ling, Matthew Wook Chang

Publikováno v: Frontiers in Bioengineering and Biotechnology, Vol 8 (2020)

Lipoic acid is a valuable organosulfur compound used as an antioxidant for dietary supplementation, and potentially anti-diabetic and anti-cancer. Currently, lipoic acid is obtained mainly through chemical synthesis, which requires toxic reagents and

Externí odkaz: https://doaj.org/article/b70b1667f84b4727a7bf72f533fc9c8b

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Akademický článek

Using Lipoamidase as a Novel Probe To Interrogate the Importance of Lipoylation in Plasmodium falciparum

Autor: Hugo Jhun, Maroya S. Walters, Sean T. Prigge

Publikováno v: mBio, Vol 9, Iss 6 (2018)

ABSTRACT Lipoate is a redox active cofactor that is covalently bound to key enzymes of oxidative metabolism. Plasmodium falciparum is auxotrophic for lipoate during the intraerythrocytic stages, but it is not known whether lipoate attachment to prote

Externí odkaz: https://doaj.org/article/502d1e6012884896b8b15b441452fe91

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Akademický článek

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Using Lipoamidase as a Novel Probe To Interrogate the Importance of Lipoylation in Plasmodium falciparum

Autor: Sean T. Prigge, Hugo Jhun, Maroya S. Walters

Publikováno v: mBio, Vol 9, Iss 6, p e01872-18 (2018)
mBio
mBio, Vol 9, Iss 6 (2018)

Lipoate is an essential cofactor for a small number of enzymes that are important for central metabolism. Malaria parasites require lipoate scavenged from the human host for growth and survival; however, it is not known why this cofactor is so import

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7720b9f5f5ba993c22336160cc1c4559
https://doaj.org/article/4f20ac7748c14616930d8500140fda57

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Akademický článek

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Sirtuin Lipoamidase Activity Is Conserved in Bacteria as a Regulator of Metabolic Enzyme Complexes

Autor: Elizabeth A. Rowland, Todd M. Greco, Caroline K. Snowden, Anne L. McCabe, Thomas J. Silhavy, Ileana M. Cristea, R. John Collier

Publikováno v: mBio, Vol 8, Iss 5 (2017)
mBio, Vol 8, Iss 5, p e01096-17 (2017)
mBio

Lipoic acid is an essential metabolic cofactor added as a posttranslational modification on several multimeric enzyme complexes. These protein complexes, evolutionarily conserved from bacteria to humans, are core regulators of cellular metabolism. Wh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f48f569b9e57563bbf246e274129fc1
https://journals.asm.org/doi/10.1128/mBio.01096-17

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Sirtuin 4 Is a Lipoamidase Regulating Pyruvate Dehydrogenase Complex Activity

Autor: Todd M. Greco, Adam Oberstein, Yibin Kang, Rommel A. Mathias, Ileana M. Cristea, Rumela Chakrabarti, Hanna G. Budayeva, Elizabeth A. Rowland, Thomas Shenk

Publikováno v: Cell. 159(7):1615-1625

SummarySirtuins (SIRTs) are critical enzymes that govern genome regulation, metabolism, and aging. Despite conserved deacetylase domains, mitochondrial SIRT4 and SIRT5 have little to no deacetylase activity, and a robust catalytic activity for SIRT4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::462d96603deb3919674457450d3aef47

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Activity assay of Lipoamidase, an expected modulator of metabolic fate of externally administered lipoic acid

Autor: Man-yuan Wang, Seiichi Matsugo, Rouhollah Motafakkerazad, Naoki Wada, Tetsuya Konishi

Publikováno v: Inflammation and Regeneration. 31:88-94

α-Lipoic acid (LA) is a cofactor functioning in four multienzymes: pyruvate dehydrogenase, α-ketoglutarate dehydrogenase, branched-chain α-keto acid dehydrogenase, and the glycine cleavage enzyme systems. In each enzyme, LA is covalently bound to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::49eb43f115cda7de01a70cd5e7da6440
https://doi.org/10.2492/inflammregen.31.88

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Akademický článek

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Isoelectric focusing of biotinidase and lipoamidase with the addition of non-ionic detergent

Autor: Motonobu Hosoya, Kou Hayakawa, Jun Oizumi, Masahiko Hirano

Publikováno v: Analytica Chimica Acta. 372:281-289

Isoelectric focusing (IEF) of purified biotinidase and lipoamidase (sialylated glycoprotein enzymes) was found to be reproducible and reliable when non-ionic detergent, Nonidet P-40 (NP-40), was added at 1% (v/v). Applications of the IEF containing 1

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c06e48a470fbf5dbcdbcb9c8aae2fdea
https://doi.org/10.1016/s0003-2670(98)00340-7

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