Výsledky vyhledávání - "Liping, Goddard"

Akademický článek

Levels and in vitro functional effects of circulating anti-hinge antibodies in melanoma patients receiving the immune checkpoint inhibitor pembrolizumab.

Autor: Barry D Hock, Liping Goddard, Sean A MacPherson, Matthew Strother, David Gibbs, John F Pearson, Judith L McKenzie

Publikováno v: PLoS ONE, Vol 18, Iss 9, p e0290793 (2023)

The efficacy of PD-1 monoclonals such as pembrolizumab can be modulated by the signals delivered via their Fc region. Tumour/inflammation associated proteases can generate F(ab')2 fragments of therapeutic monoclonals, and subsequent recognition of F(

Externí odkaz: https://doaj.org/article/5c5343f1c5614282a9d7c4d55c3316c4

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Long‐Term Fine Motor Capability on the Staircase Test Correlates with the Absolute Number, but Not the Density, of DARPP‐Positive Neurons in the Caudate‐Putamen

Autor: Dorothy E. Oorschot, Liping Goddard, Benjamin E. Aghoghovwia

Publikováno v: The Anatomical Record. 302:2040-2048

Measurement of long-term functional and anatomical outcomes in the same animal is considered a powerful strategy for correlating structure with function. In a neonatal animal model of hypoxic-ischemic brain injury that is relevant to cerebral palsy,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73cab1fb7d92649ad4ccadc7e32467e3
https://doi.org/10.1002/ar.24196

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Discrimination of Anti-drug Antibodies With Neutralizing Capacity in Infliximab- and Adalimumab-Treated Patients: Comparison of the Homogeneous Mobility Shift Assay and the Affinity Capture and Elution Assay

Autor: Stewart M. Smith, Barry D. Hock, Christopher J McEntyre, Judith L. McKenzie, Paula E. Keating, Liping Goddard

Publikováno v: Therapeutic Drug Monitoring. 40:705-715

The measurement of anti-drug antibody (ADA) levels in adalimumab (ADAL)-treated and infliximab (IFX)-treated patients is critical for guiding therapeutic strategies. The homogeneous mobility shift assay (HMSA) and affinity capture elution (ACE) assay

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::886522304f71e0af78d073c8466688ef
https://doi.org/10.1097/ftd.0000000000000553

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Functional effects of immune complexes formed between pembrolizumab and patient-generated anti-drug antibodies

Autor: Barry D. Hock, Margaret J. Currie, Leah Butt, Liping Goddard, Matthew Strother, Judith L. McKenzie

Publikováno v: Cancer immunology, immunotherapy : CII. 69(12)

The PD-1-targeting IgG4 antibody pembrolizumab has significant anti-tumor activity in a proportion of stage IV melanoma patients. A subset of patients develop anti-drug antibodies (ADA) which can form immune complexes (IC) with pembrolizumab. Althoug

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98a6a97776524889622c08940fdb4f46
https://pubmed.ncbi.nlm.nih.gov/32556495

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Marked differences in the number and type of synapses innervating the somata and primary dendrites of midbrain dopaminergic neurons, striatal cholinergic interneurons, and striatal spiny projection neurons in the rat

Autor: John N. J. Reynolds, Naili Lin, Louise C. Parr-Brownlie, Liping Goddard, Timothy Wastney, Rachel J. Sizemore, Dorothy E. Oorschot, Rong Zhang

Publikováno v: Journal of Comparative Neurology. 524:1062-1080

Elucidating the link between cellular activity and goal-directed behavior requires a fuller understanding of the mechanisms underlying burst firing in midbrain dopaminergic neurons and those that suppress activity during aversive or non-rewarding eve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b623cbb5bf019e1dddd7b30127ccbabf
https://doi.org/10.1002/cne.23891

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Spectrum of Short- and Long-Term Brain Pathology and Long-Term Behavioral Deficits in Male Repeated Hypoxic Rats Closely Resembling Human Extreme Prematurity

Autor: Liping Goddard, Sarah E. Kohe, Logan J. Voss, David K. Bilkey, Penny Birchall, William Huang, Matthew V. Covey, Dorothy E. Oorschot

Publikováno v: Journal of Neuroscience. 33:11863-11877

Brain injury in the premature infant is associated with a high risk of neurodevelopmental disability. Previous small-animal models of brain injury attributable to extreme prematurity typically fail to generate a spectrum of pathology and behavior tha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bee2fe2a867f612a14b23dc579a57d3
https://doi.org/10.1523/jneurosci.0342-12.2013

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Delayed post-treatment with bone marrow-derived mesenchymal stem cells is neurorestorative of striatal medium-spiny projection neurons and improves motor function after neonatal rat hypoxia-ischemia

Autor: Rachel J. Sizemore, Emma K. Gowing, Stella H. Cameron, Liping Goddard, Elizabeth R. Barnett, Amr J. Alwakeel, Catherine E. Hobbs, Dorothy E. Oorschot, Sarah E. Kohe

Publikováno v: Molecular and cellular neurosciences. 68

Perinatal hypoxia–ischemia is a major cause of striatal injury and may lead to cerebral palsy. This study investigated whether delayed administration of bone marrow-derived mesenchymal stem cells (MSCs), at one week after neonatal rat hypoxia–isc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa38eedb6f2569689ca717246a5eb484
https://pubmed.ncbi.nlm.nih.gov/25828540

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Autor: Rachel J, Sizemore, Rong, Zhang, Naili, Lin, Liping, Goddard, Timothy, Wastney, Louise C, Parr-Brownlie, John N J, Reynolds, Dorothy E, Oorschot

Publikováno v: The Journal of comparative neurology. 524(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5a5717aeefca54c9d2c4c8059a4575ef
https://pubmed.ncbi.nlm.nih.gov/26355230

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