Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Lipika R Pal"'
Autor:
Ariel Dadush, Rona Merdler-Rabinowicz, David Gorelik, Ariel Feiglin, Ilana Buchumenski, Lipika R. Pal, Shay Ben-Aroya, Eytan Ruppin, Erez Y. Levanon
Publikováno v:
npj Genomic Medicine, Vol 9, Iss 1, Pp 1-11 (2024)
Abstract The majority of human genetic diseases are caused by single nucleotide variants (SNVs) in the genome sequence. Excitingly, new genomic techniques known as base editing have opened efficient pathways to correct erroneous nucleotides. Due to r
Externí odkaz:
https://doaj.org/article/d3188adc91be407baf8d687f3b98408a
Autor:
Yizhou Yin, Matthew G. Romei, Kannan Sankar, Lipika R. Pal, Kam Hon Hoi, Yanli Yang, Brandon Leonard, Gladys De Leon Boenig, Nikit Kumar, Marissa Matsumoto, Jian Payandeh, Seth F. Harris, John Moult, Greg A. Lazar
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 4952-4968 (2022)
Antibodies are fundamental effectors of humoral immunity, and have become a highly successful class of therapeutics. There is increasing evidence that antibodies utilize transient homotypic interactions to enhance function, and elucidation of such in
Externí odkaz:
https://doaj.org/article/60f793838e994b85be80002d6d453dc0
Autor:
Lipika R. Pal, Kuoyuan Cheng, Nishanth Ulhas Nair, Laura Martin-Sancho, Sanju Sinha, Yuan Pu, Laura Riva, Xin Yin, Fiorella Schischlik, Joo Sang Lee, Sumit K. Chanda, Eytan Ruppin
Publikováno v:
iScience, Vol 25, Iss 5, Pp 104311- (2022)
Summary: Novel strategies are needed to identify drug targets and treatments for the COVID-19 pandemic. The altered gene expression of virus-infected host cells provides an opportunity to specifically inhibit viral propagation via targeting the synth
Externí odkaz:
https://doaj.org/article/38f812d912a2472cacf9acc270fddacc
Autor:
Kuoyuan Cheng, Laura Martin‐Sancho, Lipika R Pal, Yuan Pu, Laura Riva, Xin Yin, Sanju Sinha, Nishanth Ulhas Nair, Sumit K Chanda, Eytan Ruppin
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 11, Pp n/a-n/a (2021)
Abstract Tremendous progress has been made to control the COVID‐19 pandemic caused by the SARS‐CoV‐2 virus. However, effective therapeutic options are still rare. Drug repurposing and combination represent practical strategies to address this u
Externí odkaz:
https://doaj.org/article/7f7daa898bfc42e18657f5c1309d7466
Publikováno v:
PLoS Computational Biology, Vol 14, Iss 12, p e1006540 (2018)
Mechanism is a widely used concept in biology. In 2017, more than 10% of PubMed abstracts used the term. Therefore, searching for and reasoning about mechanisms is fundamental to much of biomedical research, but until now there has been almost no com
Externí odkaz:
https://doaj.org/article/7fab0f8106a845bb8139d3e982130e2e
Autor:
Matthew Nagy, Fiorella Schischlik, Kun Wang, Nishanth Ulhas Nair, E. Michael Gertz, Lipika R. Pal, Natalie Jaeger, Christopher Previti, Dina ElHarouni, Stefan M. Pfister, Eytan Ruppin
Publikováno v:
Cancer Research. 83:3118-3118
Introduction: PARP inhibitors (PARPi) are known to have a synthetic lethal (SL) relationship with BRCA1/2 mutated cancers (ie: BRCA loss confers sensitivity to PARPi), but heterogeneity in response exists. PARPi have also found utility in BRCA-non mu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d9b422b0cb4cd4acbd4bd47f11eba4e5
https://doi.org/10.1158/1538-7445.am2023-3118
https://doi.org/10.1158/1538-7445.am2023-3118
Autor:
Nishanth Ulhas Nair, Kuoyuan Cheng, Lamis Naddaf, Elad Sharon, Lipika R. Pal, Padma S. Rajagopal, Irene Unterman, Kenneth Aldape, Sridhar Hannenhalli, Chi-Ping Day, Yuval Tabach, Eytan Ruppin
Publikováno v:
Science Advances. 8
Cancer is a predominant disease across animals. We applied a comparative genomics approach to systematically characterize genes whose conservation levels correlate positively (PC) or negatively (NC) with cancer resistance estimates across 193 vertebr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12a0478b87703e497f5ce407ba40ce96
https://doi.org/10.1126/sciadv.abj7176
https://doi.org/10.1126/sciadv.abj7176
Autor:
Yizhou Yin, Matthew Romei, Kannan Sankar, Lipika R. Pal, Kam Hon Hoi, Yanli Yang, Brandon Leonard, Gladys De Leon Boenig, Nikit Kumar, Marissa Matsumoto, Jian Payandeh, Seth F. Harris, John Moult, Greg A. Lazar
Antibodies are fundamental effectors of humoral immunity, and have become a highly successful class of therapeutics. There is increasing evidence that antibodies utilize transient homotypic interactions to enhance function, and elucidation of such in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::88c034711e21402060f023147b15aa92
https://doi.org/10.1101/2022.04.06.487381
https://doi.org/10.1101/2022.04.06.487381
Autor:
Lipika R. Pal, Kuoyuan Cheng, Nishanth Ulhas Nair, Laura Martin-Sancho, Sanju Sinha, Yuan Pu, Laura Riva, Xin Yin, Fiorella Schischlik, Joo Sang Lee, Sumit Chanda, Eytan Ruppin
Publikováno v:
Cancer Research. 82:3583-3583
Introduction: Despite the development of two mRNA vaccines, there is an urgent unmet need of finding new antiviral strategies. One such potential antiviral strategy is to target the synthetic lethal (SL) partners of transcriptionally altered genes in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48c340e1a10d6290adee5ed5c6e8c7a2
https://doi.org/10.1158/1538-7445.am2022-3583
https://doi.org/10.1158/1538-7445.am2022-3583
Autor:
Eytan Ruppin, Padma Sheila Rajagopal, Nishanth Ulhas Nair, Chi-Ping Day, Naddaf L, Elad Sharon, Lipika R. Pal, Yuval Tabach, Irene Unterman, Kenneth Aldape, Kuoyuan Cheng, Sridhar Hannenhalli
Cancer is an evolutionarily conserved disease that occurs in a wide variety of species. We applied a comparative genomics approach to systematically characterize the genes whose conservation levels significantly correlates positively (PC) or negative
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9b088f813fb7b1bd3f961ef8f2bb9834
https://doi.org/10.1101/2021.05.19.444895
https://doi.org/10.1101/2021.05.19.444895