Výsledky vyhledávání - "Lipid-protein interaction"

Akademický článek

A binding site for phosphoinositides described by multiscale simulations explains their modulation of voltage-gated sodium channels

Autor: Yiechang Lin, Elaine Tao, James P Champion, Ben Corry

Publikováno v: eLife, Vol 12 (2024)

Voltage-gated sodium channels (Naᵥ) are membrane proteins which open to facilitate the inward flux of sodium ions into excitable cells. In response to stimuli, Naᵥ channels transition from the resting, closed state to an open, conductive state, b

Externí odkaz: https://doaj.org/article/4415fc58b8154181acbac0a3b7cad5e7

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Akademický článek

PI(4,5)P2 binding sites in the Ebola virus matrix protein VP40 modulate assembly and budding

Autor: Kristen A. Johnson, Melissa R. Budicini, Nisha Bhattarai, Tej Sharma, Sarah Urata, Bernard S. Gerstman, Prem P. Chapagain, Sheng Li, Robert V. Stahelin

Publikováno v: Journal of Lipid Research, Vol 65, Iss 3, Pp 100512- (2024)

Ebola virus (EBOV) causes severe hemorrhagic fever in humans and is lethal in a large percentage of those infected. The EBOV matrix protein viral protein 40 kDa (VP40) is a peripheral binding protein that forms a shell beneath the lipid bilayer in vi

Externí odkaz: https://doaj.org/article/8a3341cab06f4c60a01e5ef7dbe9ff15

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Akademický článek

Membrane binding and lipid-protein interaction of the C2 domain from coagulation factor V

Autor: Y. Zenmei Ohkubo, Peter W. Radulovic, Albert N. Kahira, Jesper J. Madsen

Publikováno v: Current Research in Structural Biology, Vol 7, Iss , Pp 100149- (2024)

Anchoring of coagulation factors to anionic regions of the membrane involves the C2 domain as a key player. The rate of enzymatic reactions of the coagulation factors is increased by several orders of magnitude upon membrane binding. However, the pre

Externí odkaz: https://doaj.org/article/886c5ae8c23649d787a20b92e1d182ca

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Akademický článek

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Akademický článek

Interplay between VSD, pore, and membrane lipids in electromechanical coupling in HCN channels

Autor: Ahmad Elbahnsi, John Cowgill, Verena Burtscher, Linda Wedemann, Luise Zeckey, Baron Chanda, Lucie Delemotte

Publikováno v: eLife, Vol 12 (2023)

Hyperpolarized-activated and cyclic nucleotide-gated (HCN) channels are the only members of the voltage-gated ion channel superfamily in mammals that open upon hyperpolarization, conferring them pacemaker properties that are instrumental for rhythmic

Externí odkaz: https://doaj.org/article/a778ab82133345d6a0097b0f26ea1a96

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