Zobrazeno 1 - 10
of 942
pro vyhledávání: '"Lipid-anchored protein"'
Publikováno v:
Curr Opin Chem Biol
Protein S-acylation is a prevalent post-translational protein lipidation that is dynamically regulated by “writer” protein S-acyltransferases and “eraser” acylprotein thioesterases. The protein S-acyltransferases are comprised of 23 Aspartate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f360e1203102a3b22017b59d3d3cd392
https://doi.org/10.1016/j.cbpa.2021.07.002
https://doi.org/10.1016/j.cbpa.2021.07.002
Autor:
Zhifeng Chen, Bing Zhou, Cheng Luo, Junchi Hu, Chinatsu Otomo, Xie Yuli, Yongjun Dang, Liyan Yue, Yuanyuan Zhang, Lianchun Li, Naixia Zhang, Wei Wan, Junyan Lu, Hualiang Jiang, Takanori Otomo, Yi Wen, Quanfu Li, Lin Tingting, Hongru Tao, Zhiyi Yao, Hong Ding, Pan Xu, Mingrui Zhu, Bidong Zhang, Minjia Tan, Kaixian Chen, Shijie Fan
Publikováno v:
Angew Chem Int Ed Engl
The autophagic ubiquitin-like protein LC3 functions through interactions with LC3-interaction regions (LIRs) of other autophagy proteins, including autophagy receptors, which stands out as a promising protein-protein interaction (PPI) target for the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208993b70ca522f483ad2e1adae36341
https://doi.org/10.1002/anie.202109464
https://doi.org/10.1002/anie.202109464
Autor:
Shinsaku Maruta, Daiki Morita, Makoto Miyata, Seigo Iwata, Yuhei O Tahara, Yasunobu Sugimoto, Rufiat Nahar
Publikováno v:
The Journal of Biochemistry. 171:215-225
The lipid-anchored small G protein Ras is a central regulator of cellular signal transduction processes, thereby functioning as a molecular switch. Ras forms a nanocluster on the plasma membrane by modifying lipids in the hypervariable region (HVR) a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fce50d52db00de87ecd586b8aad84a00
https://doi.org/10.1093/jb/mvab120
https://doi.org/10.1093/jb/mvab120
Autor:
Jeong Hwan Kim, Lamichhane Shrawani, Sangkil Lee, Gyubin Noh, Santosh Bashyal, Jo-Eun Seo, Taekwang Keum
Publikováno v:
Journal of Pharmaceutical Investigation. 52:75-93
The biopharmaceuticals market has grown rapidly in recent years owing to the low toxicity and high therapeutic efficacy of peptide and protein drugs. However, due to their low stability, biopharmaceuticals have to be administrated via invasive routes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e58235f6ea9943d054871a3c38d108a0
https://doi.org/10.1007/s40005-021-00549-5
https://doi.org/10.1007/s40005-021-00549-5
Autor:
Svenja C. Saile, Marc T. Nishimura, Farid El Kasmi, Jutta Keicher, Vera Bonardi, Yvon Jaillais, Claudia Oecking, Eva Stöbbe, Li Wan, Jeffery L. Dangl, Frank M. Ackermann, Mehdi Doumane, Sruthi Sunil, Adam M. Bayless, Marie-Cécile Caillaud
Publikováno v:
New Phytologist
New Phytologist, inPress, 232 (6), pp.2440-2456. ⟨10.1111/nph.17788⟩
New Phytologist, Wiley, In press, 232 (6), pp.2440-2456. ⟨10.1111/nph.17788⟩
New Phytologist, inPress, 232 (6), pp.2440-2456. ⟨10.1111/nph.17788⟩
New Phytologist, Wiley, In press, 232 (6), pp.2440-2456. ⟨10.1111/nph.17788⟩
International audience; Activation of nucleotide-binding leucine-rich repeat receptors (NLRs) results in immunity and a localized cell death. NLR cell death activity requires oligomerization and in some cases plasma membrane (PM) localization. The ex
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b9593faeb244a9418c35d5f7e8bbb3e
https://doi.org/10.1111/nph.17788
https://doi.org/10.1111/nph.17788
Autor:
Anurag Mehta, Michael D. Shapiro
Publikováno v:
Nature Reviews Cardiology. 19:168-179
Apolipoproteins are important structural components of plasma lipoproteins that influence vascular biology and atherosclerotic disease pathophysiology by regulating lipoprotein metabolism. Clinically important apolipoproteins related to lipid metabol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ae65adfd8c757d1364fd87290b98334
https://doi.org/10.1038/s41569-021-00613-5
https://doi.org/10.1038/s41569-021-00613-5
Autor:
Rasmus Jorgensen, Luise Gram Schleiss, Kirsten Raun, Jacob Kofoed, Claus Bekker Jeppesen, Birgitte Schjellerup Wulff, Berit Østergaard Christoffersen, Jørgen Olsen, Lars Ynddal, Franziska Zosel, Ulrich Sensfuss, Johan F. Paulsson, Søren Østergaard, Jane Spetzler, Flemming S Nielsen
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Peptides are notoriously known to display very short in vivo half-lives often measured in minutes which in many cases greatly reduces or eliminates sufficient in vivo efficacy. To obtain long half-lives allowing for up to once-weekly dosing regimen,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b070773ae97f4392dec87755c1751435
https://doaj.org/article/cec7ec4e645c44c5a30946919c1e7741
https://doaj.org/article/cec7ec4e645c44c5a30946919c1e7741
Autor:
Igor Maksimovic, Yael David
Publikováno v:
Trends Biochem Sci
The interior of the cell abounds with reactive species that can accumulate as non-enzymatic covalent modifications (NECMs) on biological macromolecules. These adducts interfere with many cellular processes, for example by altering proteins’ surface
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::004e46e9c9fb1eeb88c2fa1ac8f8e463
https://doi.org/10.1016/j.tibs.2021.04.004
https://doi.org/10.1016/j.tibs.2021.04.004
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Scientific Reports
Scientific Reports
Macrothrombocytopenia is a common pathology of missense mutations in genes regulating actin dynamics. Takenouchi-Kosaki syndrome (TKS) harboring the c.191A > G, Tyr64Cys (Y64C) variant in Cdc42 exhibits a variety of clinical manifestations, including
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f725c476b6bb265f4060bce5c9d2f47
https://doaj.org/article/421a4557f37544e488a883474ac7b586
https://doaj.org/article/421a4557f37544e488a883474ac7b586
Autor:
Kazuaki Matoba, Nobuo N. Noda
Publikováno v:
Biological and Pharmaceutical Bulletin. 44:1337-1343
Autophagy is an intracellular degradation system regulating cellular homeostasis. The two ubiquitin-like modification systems named the Atg8 system and the Atg12 system are essential for autophagy. Atg8 and Atg12 are ubiquitin-like proteins covalentl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a56b8993de783640a2d9b5eca7b433ec
https://doi.org/10.1248/bpb.b21-00439
https://doi.org/10.1248/bpb.b21-00439