Zobrazeno 1 - 10
of 6 706
pro vyhledávání: '"Lipid nanoparticle"'
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 10, Pp 4591-4607 (2024)
The lipid nanoparticle (LNP) has been so far proven as a strongly effective delivery system for mRNA and siRNA. However, the mechanisms of LNP's distribution, metabolism, and elimination are complicated, while the transportation and pharmacokinetics
Externí odkaz:
https://doaj.org/article/7e75c8b5a5c44e5f9127195adbf90d47
Autor:
Ebrahim Taiedinejad, Cornelius Bausch, Jörn Wittek, Gökhan Gül, Peer Erfle, Nicolai Schwarz, Mohadeseh Mozafari, Michael Baßler, Andreas Dietzel
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Abstract Pharmaceutical formulations are increasingly based on drug nanoparticles or carrier nanoparticles encapsulating drugs or mRNA molecules. Sizes and monodispersity of the nanoparticles regulate bioavailability, pharmacokinetics and pharmacolog
Externí odkaz:
https://doaj.org/article/77b7ec267d7a4c6f9ed9b029aaa6c998
Publikováno v:
Journal of Translational Medicine, Vol 22, Iss 1, Pp 1-17 (2024)
Abstract Background Integrin α5β1 plays a crucial role in the invasion of nonphagocytic cells by Staphylococcus aureus (S. aureus), thereby facilitating infection development. Lipid nanoparticles (LNPs) serve as an effective vehicle for delivering
Externí odkaz:
https://doaj.org/article/fcf470d92454439c8069091008fa2160
Autor:
Yuki Mochida, Satoshi Uchida
Publikováno v:
RNA Biology, Vol 21, Iss 1, Pp 1-27 (2024)
ABSTRACTAdjuvanticity and delivery are crucial facets of mRNA vaccine design. In modern mRNA vaccines, adjuvant functions are integrated into mRNA vaccine nanoparticles, allowing the co-delivery of antigen mRNA and adjuvants in a unified, all-in-one
Externí odkaz:
https://doaj.org/article/484502ec6d7f4372b2fd86b2d8fd6a78
Autor:
Edy Subroto, Zaida Zaida, Rossi Indiarto, Putri Widyanti Harlina, Robi Andoyo, Fang Geng, Fathi Rahmawati
Publikováno v:
International Journal of Food Properties, Vol 27, Iss 1, Pp 300-313 (2024)
ABSTRACTIron fortification in the form of ferrous sulfate is associated with several disadvantages, particularly related to the unpleasant after-taste. In this context, ferrous sulfate must be encapsulated by forming solid lipid nanoparticles (SLNs),
Externí odkaz:
https://doaj.org/article/9d5862b00eed418893982e04cc576d45
Publikováno v:
International Journal of Nanomedicine, Vol Volume 19, Pp 8769-8778 (2024)
Sherin George Shaji,1 Pratikkumar Patel,1 Umar-Farouk Mamani,1 Yuhan Guo,1 Sushil Koirala,1 Chien-Yu Lin,1 Mohammed Alahmari,1 Evanthia Omoscharka,2 Kun Cheng1 1Division of Pharmacology and Pharmaceutical Sciences, School of Pharmacy, University of M
Externí odkaz:
https://doaj.org/article/a505f01fa9a7410b9658d41112bfdce1
A lipid nanoparticle platform incorporating trehalose glycolipid for exceptional mRNA vaccine safety
Autor:
Seo-Hyeon Bae, Soyeon Yoo, Jisun Lee, Hyo-Jung Park, Sung Pil Kwon, Harin Jin, Sang-In Park, Yu-Sun Lee, Yoo-Jin Bang, Gahyun Roh, Seonghyun Lee, Sue Bean Youn, In Woo Kim, Ho Rim Oh, Ashraf K. El-Damasy, Gyochang Keum, Hojun Kim, Hyewon Youn, Jae-Hwan Nam, Eun-Kyoung Bang
Publikováno v:
Bioactive Materials, Vol 38, Iss , Pp 486-498 (2024)
The rapid development of messenger RNA (mRNA) vaccines formulated with lipid nanoparticles (LNPs) has contributed to control of the COVID-19 pandemic. However, mRNA vaccines have raised concerns about their potential toxicity and clinical safety, inc
Externí odkaz:
https://doaj.org/article/c48d472deaca44c3aad77211ea466fb1
Autor:
Farnaz Khaleseh, Mohammad Barzegar-Jalali, Parvin Zakeri-Milani, Zahra Karami, Mohammad Reza Saghatchi Zanjani, Hadi Valizadeh
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 27, Iss 7, Pp 857-867 (2024)
Objective(s): Lipid-based drug delivery systems (DDS) can improve the pharmacokinetic (PK) parameters of some drugs. Especially those with a high volume of distribution (Vd) leading to off-target accumulation and toxicity. Amiodarone as an anti-arrhy
Externí odkaz:
https://doaj.org/article/265419c13d1541a3bcd5a97815c4da36
Publikováno v:
Iranian Journal of Basic Medical Sciences, Vol 27, Iss 7, Pp 904-913 (2024)
Objective(s): ”Quality by Design” (QbD) is a novel approach to product development that involves understanding the product and process, as well as the relationship between critical quality attributes (CQA) and critical process parameters (CPP). T
Externí odkaz:
https://doaj.org/article/9f2a5cf02dd641c8ac565497000ea405
Autor:
Porkizhi Arjunan, Durga Kathirvelu, Gokulnath Mahalingam, Ashish Kumar Goel, Uday George Zacharaiah, Alok Srivastava, Srujan Marepally
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 14, Iss 7, Pp 2885-2900 (2024)
Inherited genetic disorders of the liver pose a significant public health burden. Liver transplantation is often limited by the availability of donor livers and the exorbitant costs of immunosuppressive therapy. To overcome these limitations, nucleic
Externí odkaz:
https://doaj.org/article/e9b4547e8a234c618b58ae84cb260f04