Výsledky vyhledávání - "Lipase/blood"

A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis

Autor: Jacob George, Philip Newsome, Henning Grønbæk, Manuel Romero-Gómez, Syed-Mohammed Jafri, Lynsey Corless, Joanna Uddén Hemmingsson, Rodolphe Anty, Jude Oben, Vlad Ratziu, Maeva Guillaume

Publikováno v: Newsome, P N, Buchholtz, K, Cusi, K, Linder, M, Okanoue, T, Ratziu, V, Sanyal, A J, Sejling, A-S, Harrison, S A & NN9931-4296 Investigators 2021, ' A Placebo-Controlled Trial of Subcutaneous Semaglutide in Nonalcoholic Steatohepatitis ', The New England Journal of Medicine, vol. 384, no. 12, pp. 1113-1124 . https://doi.org/10.1056/NEJMoa2028395

BACKGROUND: Nonalcoholic steatohepatitis (NASH) is a common disease that is associated with increased morbidity and mortality, but treatment options are limited. The efficacy and safety of the glucagon-like peptide-1 receptor agonist semaglutide in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7cee5c2fb724a8dcdcd7dc228bf819a3
https://doi.org/10.1056/nejmoa2028395

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An intact C-terminal end of albumin is required for its long half-life in humans

Autor: Malin C. Bern, Inger Sandlie, Kasper D. Rand, Cláudia Azevedo, Algirdas Grevys, Jan Terje Andersen, Jeannette Nilsen, Bjørn Dalhus, John J Wilson, Maria Stensland, Derry C. Roopenian, Stephen O. Brennan, Kine Marita Knudsen Sand, Esben Trabjerg

Publikováno v: Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Nilsen, J, Trabjerg, E, Grevys, A, Azevedo, C, Brennan, S O, Stensland, M, Wilson, J, Sand, K M K, Bern, M, Dalhus, B, Roopenian, D C, Sandlie, I, Rand, K D & Andersen, J T 2020, ' An intact C-terminal end of albumin is required for its long half-life in humans ', Communications Biology, vol. 3, no. 1, 181 . https://doi.org/10.1038/s42003-020-0903-7
Communications Biology, 3 (1)
Communications Biology

Albumin has an average plasma half-life of three weeks and is thus an attractive carrier to improve the pharmacokinetics of fused therapeutics. The half-life is regulated by FcRn, a cellular receptor that protects against intracellular degradation. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ee2ca81be9d054502e8fe07555c5462
http://link.springer.com/article/10.1038/s42003-020-0903-7

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Preventive effect of agomelatine in lipopolysaccharide-induced pancreatic pathology

Autor: Senay Topsakal, Ozlem Ozmen

The aim of this study was to examine pancreatic lesions and the possible prophylactic effects of agomelatine (AGO) in lipopolysaccharide (LPS)-induced sepsis in rats. Twenty-four female, 1-year-old Wistar albino rats were divided into three groups: g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1dac94f757531c1ddcaa1806e981e75f
https://doi.org/10.1080/01480545.2019.1675686

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Ameliorative effect of certolizumab on experimentally induced acute necrotic pancreatitis in rats

Autor: Ozlem Ozmen, Şima Şahinduran, Özkan Herek, Mehmet Ali Kosekli

Publikováno v: Revista da Associação Médica Brasileira, Volume: 65, Issue: 2, Pages: 204-210, Published: FEB 2019
Revista da Associação Médica Brasileira, Vol 65, Iss 2, Pp 204-210
Revista da Associação Médica Brasileira v.65 n.2 2019
Revista da Associação Médica Brasileira
Associação Médica Brasileira (AMB)
instacron:AMB

SUMMARY OBJECTIVE: The effects of Certolizumab, a pegylated monoclonal antibody to tumor necrosis factor α, on experimentally induced acute pancreatitis (AP) were examined. METHODS: Thirty-six Wistar Albino male rats were randomly divided into four

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db93abe0255d978baf3db7a3fc6beb5
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0104-42302019000200204&lng=en&tlng=en

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Seven Lipoprotein Lipase Gene Polymorphisms, Lipid Fractions, and Coronary Disease: A HuGE Association Review and Meta-Analysis

Autor: Björn Wiman, Gurdeep S. Sagoo, Merel van Maarle, John J.P. Kastelein, Iain Tatt, Julian P T Higgins, Adam S. Butterworth, J. Wouter Jukema, Georgia Salanti, Anna M. Bennet, Danesh J, Ulf de Faire, Nadeem Sarwar

Publikováno v: American Journal of Epidemiology. 168:1233-1246

Lipoprotein lipase (LPL) is a key enzyme in lipoprotein metabolism and a major candidate gene for coronary heart disease (CHD). The authors assessed associations between 7 LPL polymorphisms and lipid fractions and CHD risk in population-based cohort,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cd1eebb88efd753feb431fb792401e
https://doi.org/10.1093/aje/kwn235

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Outcomes with frontline nilotinib treatment in Turkish patients with newly diagnosed Philadelphia chromosome–positive chronic myeloid leukemia in chronic phase

Autor: Osman Ilhan, Rıdvan Ali, Zafer Baslar, Ibrahim C. Haznedaroglu, Orhan Ayyildiz, Diyar Z. Akkaynak, Ugur Ozbek, Leylagül Kaynar, Mehmet Sönmez, Demet Aydin, Akif Selim Yavuz, Bülent Ündar, Ilkiz M. Dag, Mustafa Pehlivan, Güray Saydam, Birol Guvenc, Olga Meltem Akay, Simten Dagdas

PubMed ID: 27501474
Objective: Nilotinib is a BCR-ABL1 tyrosine kinase inhibitor approved for the treatment of patients with chronic myeloid leukemia in chronic phase (CML-CP). This study was the first prospective evaluation of the efficacy and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef7978eceb03118408c2e8f7f3666597
https://hdl.handle.net/20.500.12605/18279

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Effects of certolizumab on cerulein-ınduced acute pancreatitis in rats

Autor: Mehmet Ali Kosekli, Mustafa Yilmaz, Veli Cobankara, Ugur Sungurtekin, Şima Şahinduran, Ozlem Ozmen

Objectives To evaluate the effects of certolizumab, a pegylated monoclonal antibody to tumor necrosis factor α (TNF-α), on experimentally induced acute pancreatitis. Methods Healthy Wistar Albino male rats (n = 36) were randomly divided into 4 grou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbaeff73a480e7f1aea86da80212488a
https://hdl.handle.net/11499/9456

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Uncertainty in measurement for 43 biochemistry, immunoassay, and hemostasis routine analytes evaluated by a method using only external quality assessment data

Autor: Karim Chikh, Catherine Sotta, Bernard Poggi, Anne-Claude Renard, Jean-Christophe Eynard, Régine Cartier, Chantal Bon, Gladys Matar, Laurence Chardon, Roland Meley, Richard B. Cohen

Publikováno v: Clinical Chemistry and Laboratory Medicine
Clinical Chemistry and Laboratory Medicine, 2015, 53 (11), pp.1725-1736. ⟨10.1515/cclm-2014-0942⟩

International organizations require from medical laboratories a quantitative statement of the uncertainty in measurement (UM) to help interpret patient results. The French accreditation body (COFRAC) recommends an approach (SH GTA 14 IQC/EQA method)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6edc880f88181068f770f69f92e0fd67
https://pubmed.ncbi.nlm.nih.gov/25811667

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Serial serum feline pancreatic lipase immunoreactivity concentrations and prognostic variables in 33 cats with pancreatitis

Autor: Stockhaus, C., Teske, E., Schellenberger, K., Huisinga, E., Konietschke, U., Mangelsdorf, S., Steiner, J.M., Advances in Veterinary Medicine, Geneeskunde van gezelschapsdieren

Publikováno v: Journal of the American Veterinary Medical Association, 243, 1713. American Veterinary Medical Association

Objective—To identify factors significantly associated with prognosis in cats hospitalized because of pancreatitis. Design—Prospective case series. Animals—33 cats hospitalized for treatment of pancreatitis (diagnosis determined on the basis of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f7f0bc67238365bbf57b2c973565fe6
https://dspace.library.uu.nl/handle/1874/314213

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Systemic treatment-induced gastrointestinal toxicity: Incidence, clinical presentation and management

Autor: Boussios, Stergios, Pentheroudakis, George, Katsanos, K., Pavlidis, Nicholas

Publikováno v: Annals of Gastroenterology

The toxicity of cancer chemotherapy is among the most important factors limiting its use. Clear delineation and communication of benefits and risks is an essential component of treatment decisions. Gastrointestinal toxicity during chemotherapy is fre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______4485::5cab148913c6280274d04a76510cac24
https://gnosis.library.ucy.ac.cy/handle/7/41464

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