Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lioudmila Tchistiakov"'
Autor:
Renée Procopio-Melino, Frank W. Kotch, Amar S. Prashad, Jose M. Gomes, Wenge Wang, Bo Arve, Andrew Dawdy, Lawrence Chen, Justin Sperry, Christine Hosselet, Tao He, Ronald Kriz, Laura Lin, Kimberly Marquette, Lioudmila Tchistiakova, Will Somers, Jason C. Rouse, Xiaotian Zhong
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Next-generation site-specific cysteine-based antibody–drug-conjugates (ADCs) broaden therapeutic index by precise drug-antibody attachments. However, manufacturing such ADCs for clinical validation requires complex full reduction and reoxi
Externí odkaz:
https://doaj.org/article/5cda877d16ac4d3e838e8490f8f4c4f8
Autor:
Adam R. Root, Gurkan Guntas, Madan Katragadda, James R. Apgar, Jatin Narula, Chew Shun Chang, Sara Hanscom, Matthew McKenna, Jason Wade, Caryl Meade, Weijun Ma, Yongjing Guo, Yan Liu, Weili Duan, Claire Hendershot, Amy C. King, Yan Zhang, Eric Sousa, Amy Tam, Susan Benard, Han Yang, Kerry Kelleher, Fang Jin, Nicole Piche-Nicholas, Sinead E. Keating, Fernando Narciandi, Rosemary Lawrence-Henderson, Maya Arai, Wayne R. Stochaj, Kristine Svenson, Lidia Mosyak, Khetemcnee Lam, Christopher Francis, Kimberly Marquette, Liliana Wroblewska, H. Lily Zhu, Alfredo Darmanin Sheehan, Edward R. LaVallie, Aaron M. D’Antona, Alison Betts, Lindsay King, Edward Rosfjord, Orla Cunningham, Laura Lin, Puja Sapra, Lioudmila Tchistiakova, Divya Mathur, Laird Bloom
Publikováno v:
mAbs, Vol 13, Iss 1 (2021)
We report here the discovery and optimization of a novel T cell retargeting anti-GUCY2C x anti-CD3ε bispecific antibody for the treatment of solid tumors. Using a combination of hybridoma, phage display and rational design protein engineering, we ha
Externí odkaz:
https://doaj.org/article/25a52ae4f12b462d933f760c7786789d
Autor:
Adam R. Root, Wei Cao, Bilian Li, Peter LaPan, Caryl Meade, Jocelyn Sanford, Macy Jin, Cliona O’Sullivan, Emma Cummins, Matthew Lambert, Alfredo D. Sheehan, Weijun Ma, Scott Gatto, Kelvin Kerns, Khetemenee Lam, Aaron M. D’Antona, Lily Zhu, William A. Brady, Susan Benard, Amy King, Tao He, Lisa Racie, Maya Arai, Dianah Barrett, Wayne Stochaj, Edward R. LaVallie, James R. Apgar, Kristine Svenson, Lidia Mosyak, Yinhua Yang, Gurunadh R. Chichili, Liqin Liu, Hua Li, Steve Burke, Syd Johnson, Ralph Alderson, William J. J. Finlay, Laura Lin, Stéphane Olland, William Somers, Ezio Bonvini, Hans-Peter Gerber, Chad May, Paul A. Moore, Lioudmila Tchistiakova, Laird Bloom
Publikováno v:
Antibodies, Vol 5, Iss 1, p 6 (2016)
Bispecific antibodies offer a promising approach for the treatment of cancer but can be challenging to engineer and manufacture. Here we report the development of PF-06671008, an extended-half-life dual-affinity re-targeting (DART®) bispecific molec
Externí odkaz:
https://doaj.org/article/8c0c6589f19a4745bedbcd5e1b1c60a5
Autor:
Davinder Gill, David Wensel, Michel Awwad, Lioudmila Tchistiakov, Pam Szklut, Xin Xu, Yulia Vugmeyster, Garvin Warner, John Ross
Publikováno v:
Pharmaceutical Research. 28:1696-1706
Anti-Aβ Ab2 (Ab2) is a humanized monoclonal antibody against amino acids 3-6 of primate (but not rodent) amyloid β (Aβ) and is being evaluated for the treatment of Alzheimer's disease (AD). This study was conducted to predict the human pharmacokin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7869e1675391b8e80abf23f52a3b54ab
https://doi.org/10.1007/s11095-011-0405-x
https://doi.org/10.1007/s11095-011-0405-x
Autor:
Lioudmila Tchistiakov, Marla J. Matin, Alice Lee, Reid Bissonnette, Lijin feng, Sachiko Yamamoto, Joselyn Del Rosario, Yijie Gao, Vincent Blot, Gary Woodnutt, Joseph Stock, Janet Do, Michael Gallo, Rodney W. Lappe, Steven Pirie-Shepherd, Jennifer Souratha
Publikováno v:
Cancer Research. 72:2327-2327
Angiogenesis is essential for tumor growth and metastasis, and controlling tumor-associated angiogenesis is a proven therapeutic intervention to limit tumor progression. Several pathways have been involved in tumor-associated angiogenesis and the pre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3eb31fb23eb3a4e3eab4c00155657ad5
https://doi.org/10.1158/1538-7445.am2012-2327
https://doi.org/10.1158/1538-7445.am2012-2327
Autor:
Wenxue Ma, Jennifer Yang, Ping Wei, John Lippincott, Xiu Yu, Aidong Wu, Ming Qiu, Isha Rymer, Norman Greenberg, Qinghai Peng, Catriona Jamieson, Donna Marie Stone, Kang Li, Bora Han, Wenwu Zhai, Lioudmila Tchistiakov, Eugenia Kraynov, Joseph Zachwieja, Gerrit Los, Yijie Gao, Ketan S. Gajiwala
Publikováno v:
Cancer Research. 71:1765-1765
Notch signaling is deregulated in T-cell acute lymphoblastic leukemia (T-ALL) and advanced solid tumors, making it an attractive target for oncology drug development. In this present report, we describe a novel mouse monoclonal antibody, Notch1 mAb,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0fec144078922493cb1b8adb1cdeab73
https://doi.org/10.1158/1538-7445.am2011-1765
https://doi.org/10.1158/1538-7445.am2011-1765
Autor:
Kenneth G. Geles, Yijie Gao, Andreas Giannakou, Latha Sridharan, Ting-Ting Yamin, Jing Zhang, Riyez Karim, Joel Bard, Nicole Piche-Nicholas, Manoj Charati, Andreas Maderna, Judy Lucas, Jonathon Golas, Magali Guffroy, Steven Pirie-Shepherd, Marc Roy, Jessie Qian, Tania Franks, Wenyan Zhong, Christopher J. O’Donnell, Lioudmila Tchistiakova, Hans-Peter Gerber, Puja Sapra
Publikováno v:
Cell Reports Medicine, Vol 2, Iss 5, Pp 100279- (2021)
Summary: Aberrant NOTCH3 signaling and overexpression is oncogenic, associated with cancer stem cells and drug resistance, yet therapeutic targeting remains elusive. Here, we develop NOTCH3-targeted antibody drug conjugates (NOTCH3-ADCs) by bioconjug
Externí odkaz:
https://doaj.org/article/76d0c5083adc4e25955529b3fcfbbf6d