Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Lioudmila, Zoubak"'
Autor:
Johanna Becker-Baldus, Alexei Yeliseev, Thomas T. Joseph, Snorri Th. Sigurdsson, Lioudmila Zoubak, Kirk Hines, Malliga R. Iyer, Arjen van den Berg, Sam Stepnowski, Jon Zmuda, Klaus Gawrisch, Clemens Glaubitz
Publikováno v:
ACS Omega, Vol 8, Iss 36, Pp 32963-32976 (2023)
Externí odkaz:
https://doaj.org/article/543ddeac6e3345cbaafa6a8240ec5d13
Autor:
Alexei Yeliseev, Malliga R. Iyer, Thomas T. Joseph, Nathan J. Coffey, Resat Cinar, Lioudmila Zoubak, George Kunos, Klaus Gawrisch
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity ligands of human cannabinoid receptor CB2, we demonstrate that cholesterol increases b
Externí odkaz:
https://doaj.org/article/f7405dfa40aa4301afa918bbd3f3c38d
Autor:
Lioudmila Zoubak, Roderic G. Eckenhoff, Weiming Bu, Grace Brannigan, Alexei Yeliseev, Thomas T. Joseph, Renyu Liu, Wenzhen Lin
Publikováno v:
ACS Chemical Neuroscience
Ketamine is an anesthetic, analgesic, and antidepressant whose secondary metabolite (2R,6R)-hydroxynorketamine (HNK) has N-methyl-d-aspartate-receptor-independent antidepressant activity in a rodent model. In humans, naltrexone attenuates its antidep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2de4cdd2ff25108e6e0e12f1cb0c2ee
https://doi.org/10.1021/acschemneuro.0c00741
https://doi.org/10.1021/acschemneuro.0c00741
Publikováno v:
Journal of Biological Chemistry. 295:181-190
G protein–coupled receptors (GPCRs) comprise a large class of integral membrane proteins involved in the regulation of a broad spectrum of physiological processes and are a major target for pharmaceutical drug development. Structural studies can he
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::81d70eabcc1676ca82a76fd4c119e2b8
https://doi.org/10.1074/jbc.ra119.010696
https://doi.org/10.1074/jbc.ra119.010696
Autor:
George Kunos, Thomas T. Joseph, Resat Cinar, Klaus Gawrisch, Nathan J. Coffey, Lioudmila Zoubak, Alexei Yeliseev, Malliga R. Iyer
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Scientific Reports
Scientific Reports
Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity ligands of human cannabinoid receptor CB2, we demonstrate that cholesterol increases basal acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7543e28117e5b799a14fbd3eab2f7e3f
https://doi.org/10.1038/s41598-021-83245-6
https://doi.org/10.1038/s41598-021-83245-6
Site-selective labeling and electron paramagnetic resonance studies of human cannabinoid receptor CB
Autor:
Alexei A, Yeliseev, Kaeli, Zoretich, Levi, Hooper, Walter, Teague, Lioudmila, Zoubak, Kirk G, Hines, Klaus, Gawrisch
Publikováno v:
Biochim Biophys Acta Biomembr
Integral membrane G protein-coupled receptors (GPCR) regulate multiple physiological processes by transmitting signals from extracellular milieu to intracellular proteins and are major targets of pharmaceutical drug development. Since GPCR are inhere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::b290bb7397640f44abcaeb0fdca99a7c
https://pubmed.ncbi.nlm.nih.gov/33865808
https://pubmed.ncbi.nlm.nih.gov/33865808
Autor:
Kyle Williston, Alexei Yeliseev, Arjen van den Berg, Lioudmila Zoubak, Wanhua Yan, Sam Stepnowski, Jonathan Zmuda, Kirk G. Hines, Klaus Gawrisch
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Rational design of pharmaceutical drugs targeting integral membrane G protein-coupled receptors (GPCR) requires thorough understanding of ligand binding and mechanism of activation through high resolution structural studies of purified proteins. Due
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b8b674b0b8fcceacee23134e4437d26
https://doi.org/10.1038/s41598-020-73813-7
https://doi.org/10.1038/s41598-020-73813-7
Autor:
Alexei Yeliseev, Kaeli Zoretich, Levi Hooper, Walter E. Teague, Lioudmila Zoubak, Kirk G. Hines, Klaus Gawrisch
Publikováno v:
Biophysical Journal. 121:85a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a62614303de172a6c293be6309c7310b
https://doi.org/10.1016/j.bpj.2021.11.2287
https://doi.org/10.1016/j.bpj.2021.11.2287
Autor:
Sara Linse, Lioudmila Zoubak, Niamh Ní Mhurchú, David J. O'Connell, Alexei Yeliseev, Gavin McGauran
Publikováno v:
Biochemistry. 57:4383-4390
The process of isolating recombinant G protein-coupled receptors from membrane preparations is challenging because the process requires solubilization in detergent micelles and multistep affinity chromatography protocols. Solubilization buffers conta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cfff83d610849bcbec8da8be1dc056b4
https://doi.org/10.1021/acs.biochem.8b00469
https://doi.org/10.1021/acs.biochem.8b00469
Autor:
Kirk G. Hines, Alexei Yeliseev, Klaus Gawrisch, Walter E. Teague, Levi Hooper, Lioudmila Zoubak, Kaeli Zoretich
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1863:183621
Integral membrane G protein-coupled receptors (GPCR) regulate multiple physiological processes by transmitting signals from extracellular milieu to intracellular proteins and are major targets of pharmaceutical drug development. Since GPCR are inhere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::50709cea5f8e9a3ae630e27e3fc9ad3e
https://doi.org/10.1016/j.bbamem.2021.183621
https://doi.org/10.1016/j.bbamem.2021.183621