Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Lioubov G. Korotchkina"'
Autor:
Max Totrov, Denis N. Kazyulkin, Lioubov G. Korotchkina, Sergey Korolev, Andrei V. Gudkov, Ian J. Miller
Publikováno v:
Nucleic Acids Research
Long interspersed nuclear element-1 (L1) is an autonomous non-LTR retrotransposon comprising ∼20% of the human genome. L1 self-propagation causes genomic instability and is strongly associated with aging, cancer and other diseases. The endonuclease
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d4c542797f68a43378c10c7cce64ef5
http://europepmc.org/articles/PMC8565326
http://europepmc.org/articles/PMC8565326
Autor:
Frank Jordan, Yun-Hee Park, Mulchand S. Patel, Matthew J. Whitley, William Furey, Natalia S. Nemeria, Lioubov G. Korotchkina, Palaniappa Arjunan
Publikováno v:
Journal of Biological Chemistry. 293:13204-13213
The pyruvate dehydrogenase multienzyme complex (PDHc) connects glycolysis to the tricarboxylic acid cycle by producing acetyl-CoA via the decarboxylation of pyruvate. Because of its pivotal role in glucose metabolism, this complex is closely regulate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4f5e0d189a8986b38e68d1f67b488c
https://doi.org/10.1074/jbc.ra118.003996
https://doi.org/10.1074/jbc.ra118.003996
Autor:
Peter Krasnov, Ilia Toshkov, Michelle Haber, Michelle J. Henderson, Mahima Gupta, Pavel G. Komarov, Slavoljub Vujcic, Richard B. Lock, Yuan Tian, Murray D. Norris, Shiloh Middlemiss, Sangeeta Joshi, Denis N. Kazyulkin, Jean Veith, Lioubov G. Korotchkina, Eugene Kononov, Mikhail V. Chernov, Olga B. Chernova, Marina P. Antoch, Klaartje Somers, Andrei V. Gudkov, Alex Polinsky, Ekaterina L. Andrianova
Publikováno v:
Leukemia
Effective treatment of some types of cancer can be achieved by modulating cell lineage-specific rather than tumor-specific targets. We conducted a systematic search for novel agents selectively toxic to cells of hematopoietic origin. Chemical library
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::968c0d33d195d064d123c2e55b563e6b
https://pubmed.ncbi.nlm.nih.gov/31896781
https://pubmed.ncbi.nlm.nih.gov/31896781
Autor:
Ursula R. Kees, Murray D. Norris, Stephen W. Erickson, Tara Pritchard, Klaartje Somers, Leanna Cheung, Malcolm A. Smith, Richard B. Lock, Luke Jones, Shiloh Middlemiss, Olga B. Chernova, Ali El-Ayoubi, Mawar Karsa, Helen Forgham, Angelika Bongers, Andrei V. Gudkov, Michelle Haber, Michelle J. Henderson, Angelika Kosciolek, Mahima Gupta, Lioubov G. Korotchkina, Kathryn Evans, Beverly A. Teicher, Chelsea Mayoh
Publikováno v:
Leukemia
The prognosis for children diagnosed with high-risk acute lymphoblastic leukemia (ALL) remains sub-optimal, and more potent and less toxic treatments are urgently needed. We investigated the efficacy of a novel nicotinamide phosphoribosyltransferase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6806653ced50124da73230479f170bac
https://pubmed.ncbi.nlm.nih.gov/31848452
https://pubmed.ncbi.nlm.nih.gov/31848452
Autor:
Tim Failes, Meera Warby, Marie Wong, Emily Mould, Andrew J. Gifford, Jayne Murray, Carmela De Santo, Klaartje Somers, Olga B. Chernova, Toby Trahair, Jamie I. Fletcher, Andrei V. Gudkov, Tracey A. O'Brien, Katerina Gurova, Michelle J. Henderson, Laura D. Gamble, Lin Xiao, Murray D. Norris, Maria Tsoli, Glenn M. Marshall, Kathryn Evans, Loretta Lau, Lioubov G. Korotchkina, Ruby Pandher, Richard B. Lock, Denise Yu, Anthony J. Cesare, Mark J. Cowley, Paul G Ekert, Laura Franshaw, Anahid Ehteda, Greg M. Arndt, Marie-Emilie A. Gauthier, Jinhan Xie, Katherine M. Tucker, Paulette Barahona, Sumanth Nagabushan, Aisling O'Connor, Paul Cheng, Amit Kumar, Dylan Grebert-Wade, Aaminah Khan, Alexandra Sherstyuk, Patrick Strong, Chelsea Mayoh, Noemi Fuentes Bolanos, David S. Ziegler, Michelle Haber, Mark R. Burns, David Thomas, Dong Anh Khuong Quang, Francis Mussai, Alvin Kamili, Vanessa Tyrrell
Publikováno v:
Cancer Research. 80:IA13-IA13
Despite the increase in overall child cancer survival rates, pediatric malignancies such as high-risk neuroblastoma, high-risk leukemias (including MLL-translocated infant ALL), and aggressive brain tumors (including DIPG) remain refractory to curren
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5c4f19408f5471bce417010f2c7b9b2c
https://doi.org/10.1158/1538-7445.pedca19-ia13
https://doi.org/10.1158/1538-7445.pedca19-ia13
Autor:
Murray D. Norris, Richard B. Lock, Klaartje Somers, Michelle J. Henderson, Olga B. Chernova, Kathryn Evans, Lioubov G. Korotchkina, Andrei V. Gudkov, Michelle Haber, Leanna Cheung
Publikováno v:
ESMO Open. 3:A238
Introduction Children diagnosed with high-risk acute lymphoblastic leukaemia (ALL) have a dismal prognosis. For those patients who survive treatment, currently used chemotherapeutics are associated with severe health problems, indicating the urgent n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::950adf432e634581e8ab988877bae3db
https://doi.org/10.1136/esmoopen-2018-eacr25.563
https://doi.org/10.1136/esmoopen-2018-eacr25.563
Autor:
Lioubov G. Korotchkina, Elena I. Bukreeva, Andrei V. Gudkov, Zoya N. Demidenko, Olga V. Leontieva, Mikhail V. Blagosklonny
Publikováno v:
Aging (Albany NY)
Transient induction of p53 can cause reversible quiescence and irreversible senescence. Using nutlin-3a (a small molecule that activates p53 without causing DNA damage), we have previously identified cell lines in which nutlin-3a caused quiescence. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f19fc300cbcc625978e40d58b4ae9ad5
https://doi.org/10.18632/aging.100160
https://doi.org/10.18632/aging.100160
Publikováno v:
Proceedings of the National Academy of Sciences. 107:9660-9664
The tumor suppressor p53 is a canonical inducer of cellular senescence (irreversible loss of proliferative potential and senescent morphology). p53 can also cause reversible arrest without senescent morphology, which has usually been interpreted as f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c78487bc7dd6c60ec5a278b0989d635
https://doi.org/10.1073/pnas.1002298107
https://doi.org/10.1073/pnas.1002298107
Autor:
Robert A. Harris, Nader D. Halim, Peter Okagaki, Michael J. Schell, Lioubov G. Korotchkina, Ajay Verma, Thomas McFate, Mulchand S. Patel, Nam Ho Jeoung, Ahmed Mohyeldin
Publikováno v:
Glia. 58:1168-1176
Glucose metabolism in nervous tissue has been proposed to occur in a compartmentalized manner with astrocytes contributing largely to glycolysis and neurons being the primary site of glucose oxidation. However, mammalian astrocytes and neurons both c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1239c149167e0969036fca9c541178c3
https://doi.org/10.1002/glia.20996
https://doi.org/10.1002/glia.20996
Publikováno v:
Cell Cycle. 8:3777-3781
Cellular senescence is characterized by irreversible loss of proliferative potential and a large, flat cell morphology. Ectopic p21 and doxorubicin induced cellular senescence in HT1080 and WI-38-tert cell lines. In the same cell lines, the Mdm2 inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47a111a08745514c64cbf80d5b0dc72d
https://doi.org/10.4161/cc.8.22.10121
https://doi.org/10.4161/cc.8.22.10121