Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Liou Y Sun"'
Autor:
Liou Y Sun, Yimin Fang, Amit Patki, Jacob JE Koopman, David B Allison, Cristal M Hill, Michal M Masternak, Justin Darcy, Jian Wang, Samuel McFadden, Andrzej Bartke
Publikováno v:
eLife, Vol 6 (2017)
Life-long lack of growth hormone (GH) action can produce remarkable extension of longevity in mice. Here we report that GH treatment limited to a few weeks during development influences the lifespan of long-lived Ames dwarf and normal littermate cont
Externí odkaz:
https://doaj.org/article/5fb2818cbebc41cf837ae2aff6dd8a3d
Autor:
Liou Y Sun, Adam Spong, William R Swindell, Yimin Fang, Cristal Hill, Joshua A Huber, Jacob D Boehm, Reyhan Westbrook, Roberto Salvatori, Andrzej Bartke
Publikováno v:
eLife, Vol 2 (2013)
We examine the impact of targeted disruption of growth hormone-releasing hormone (GHRH) in mice on longevity and the putative mechanisms of delayed aging. GHRH knockout mice are remarkably long-lived, exhibiting major shifts in the expression of gene
Externí odkaz:
https://doaj.org/article/4ce78ac1ab71494b8bc7fc2a1bcca3f1
Publikováno v:
Biomedicines, Vol 11, Iss 8, p 2117 (2023)
L-serine is a non-essential amino acid that plays a vital role in protein synthesis, cell proliferation, development, and sphingolipid formation in the central nervous system. It exerts its effects through the activation of glycine receptors and upre
Externí odkaz:
https://doaj.org/article/66a6b52f9cb74ae99be724eb8f0c8f31
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
It is well documented that the environment of the developing fetus, including availability of nutrients and presence of toxins, can have major impact on adult phenotype, age-related traits and risk of chronic disease. There is also accumulating evide
Externí odkaz:
https://doaj.org/article/d26ad81733d841e196a747e699562319
Publikováno v:
Biomedicines, Vol 11, Iss 1, p 104 (2022)
Neurodegenerative diseases feature changes in cognition, and anxiety-like and autism-like behaviors, which are associated with epigenetic alterations such as DNA methylation and histone modifications. The amino acid L-serine has been shown to have be
Externí odkaz:
https://doaj.org/article/0831e0f3095e4801b1cd4015ffe32b5b
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Growth hormone (GH) signaling plays a key role in mediating growth, development, metabolism, and lifespan regulation. However, the mechanisms of longevity regulation at the cellular and molecular level are still not well-understood. An important area
Externí odkaz:
https://doaj.org/article/4138858f0d1c49449c54d58b342301bb
Publikováno v:
Aging. 15:459-471
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3646e7ee33c8dc249d38421dd8d72359
https://doi.org/10.18632/aging.204484
https://doi.org/10.18632/aging.204484
Publikováno v:
Aging Cell.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::301e61dea470fff4eca2a2fdd5f49d72
https://doi.org/10.1111/acel.13854
https://doi.org/10.1111/acel.13854
Autor:
Liou Y. Sun, Tim R. Nagy, Andrew W. Brown, John L. Hartman, Christy S. Carter, Thomas W. Buford, Victor M. Darley-Usmar, Scott W. Ballinger, David B. Allison, Daniel L. Smith, Jianhua Zhang, Steven N. Austad
Publikováno v:
GeroScience
The UAB Nathan Shock Center focuses on comparative energetics and aging. Energetics, as defined for this purpose, encompasses the causes, mechanisms, and consequences of the acquisition, storage, and use of metabolizable energy. Comparative energetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c21fbc005f7e6ea5d03aa8982bb1a799
https://doi.org/10.1007/s11357-021-00414-1
https://doi.org/10.1007/s11357-021-00414-1
Publikováno v:
Biomedicines. 10(8)
While glucagon has long been recognized as the primary counter hormone to insulin’s actions, it has recently gained recognition as a metabolic regulator with its effects extending beyond control of glycemia. Recently developed models of tissue-spec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4eebd3730321bc7a14c8b8cf600ccda
https://pubmed.ncbi.nlm.nih.gov/36009454
https://pubmed.ncbi.nlm.nih.gov/36009454