Výsledky vyhledávání

Akademický článek

Covalent Modification of the JH2 Domain of Janus Kinase 2.

Autor: Henry SP; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Liosi ME; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Ippolito JA; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Menges F; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Newton AS; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Schlessinger J; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Jorgensen WL; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Oct 24; Vol. 13 (11), pp. 1819-1826. Date of Electronic Publication: 2022 Oct 24 (Print Publication: 2022).

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Akademický článek

Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands.

Autor: Liosi ME; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Ippolito JA; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Henry SP; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Krimmer SG; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Newton AS; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Cutrona KJ; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Olivarez RA; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Mohanty J; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Schlessinger J; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Jorgensen WL; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2022 Jun 23; Vol. 65 (12), pp. 8380-8400. Date of Electronic Publication: 2022 Jun 02.

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Akademický článek

Conversion of a False Virtual Screen Hit into Selective JAK2 JH2 Domain Binders Using Convergent Design Strategies.

Autor: Henry SP; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Liosi ME; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Ippolito JA; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Cutrona KJ; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Krimmer SG; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Newton AS; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Schlessinger J; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Jorgensen WL; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2022 Apr 21; Vol. 13 (5), pp. 819-826. Date of Electronic Publication: 2022 Apr 21 (Print Publication: 2022).

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Akademický článek

Indoloxytriazines as binding molecules for the JAK2 JH2 pseudokinase domain and its V617F variant.

Autor: Newton AS; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107., Liosi ME; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107., Henry SP; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107., Deiana L; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107., Faver JC; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107., Krimmer SG; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107.; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520-8066., Puleo DE; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520-8066., Schlessinger J; Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520-8066., Jorgensen WL; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107.

Publikováno v: Tetrahedron letters [Tetrahedron Lett] 2021 Aug 03; Vol. 77. Date of Electronic Publication: 2021 Jul 02.

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Akademický článek

Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency.

Autor: Zhang CH; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Spasov KA; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Reilly RA; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Hollander K; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Stone EA; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Ippolito JA; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Liosi ME; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Deshmukh MG; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.; M.D.-Ph.D. Program, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Tirado-Rives J; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Zhang S; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06536-0812, United States., Liang Z; Department of Molecular, Cellular, and Developmental Biology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Miller SJ; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Isaacs F; Department of Molecular, Cellular, and Developmental Biology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Lindenbach BD; Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut 06536-0812, United States., Anderson KS; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States.; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Jorgensen WL; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2021 Jul 14; Vol. 12 (8), pp. 1325-1332. Date of Electronic Publication: 2021 Jul 14 (Print Publication: 2021).

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Akademický článek

Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2.

Autor: Ghahremanpour MM; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Tirado-Rives J; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Deshmukh M; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States and., Ippolito JA; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States and., Zhang CH; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Cabeza de Vaca I; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Liosi ME; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Anderson KS; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States and.; Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Jorgensen WL; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.

Publikováno v: ACS medicinal chemistry letters [ACS Med Chem Lett] 2020 Oct 25; Vol. 11 (12), pp. 2526-2533. Date of Electronic Publication: 2020 Oct 25 (Print Publication: 2020).

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Identification of 14 Known Drugs as Inhibitors of the Main Protease of SARS-CoV-2.

Autor: Ghahremanpour MM, Tirado-Rives J, Deshmukh M, Ippolito JA, Zhang CH, de Vaca IC, Liosi ME, Anderson KS, Jorgensen WL

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2020 Aug 28. Date of Electronic Publication: 2020 Aug 28.

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Akademický článek

Selective Janus Kinase 2 (JAK2) Pseudokinase Ligands with a Diaminotriazole Core.

Autor: Liosi ME; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Krimmer SG; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Newton AS; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Dawson TK; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Puleo DE; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Cutrona KJ; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States., Suzuki Y; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Schlessinger J; Department of Pharmacology, Yale University School of Medicine, New Haven, Connecticut 06520-8066, United States., Jorgensen WL; Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, United States.

Publikováno v: Journal of medicinal chemistry [J Med Chem] 2020 May 28; Vol. 63 (10), pp. 5324-5340. Date of Electronic Publication: 2020 May 08.

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