Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lior Onn"'
Autor:
Lior Onn, Miguel Portillo, Stefan Ilic, Gal Cleitman, Daniel Stein, Shai Kaluski, Ido Shirat, Zeev Slobodnik, Monica Einav, Fabian Erdel, Barak Akabayov, Debra Toiber
Publikováno v:
eLife, Vol 9 (2020)
DNA double-strand breaks (DSB) are the most deleterious type of DNA damage. In this work, we show that SIRT6 directly recognizes DNA damage through a tunnel-like structure that has high affinity for DSB. SIRT6 relocates to sites of damage independent
Externí odkaz:
https://doaj.org/article/8ec54c204be64101928f8e9ebb75bef6
Autor:
Or Gertman, Dotan Omer, Adi Hendler, Daniel Stein, Lior Onn, Yana Khukhin, Miguel Portillo, Raz Zarivach, Haim Y. Cohen, Debra Toiber, Amir Aharoni
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Mammalian SIRT6 is a well-studied histone deacetylase that was recently shown to exhibit high protein deacylation activity enabling the removal of long chain fatty acyl groups from proteins. SIRT6 was shown to play key roles in cellular home
Externí odkaz:
https://doaj.org/article/6ccf7a040ef74caca19da73a1a727ed2
Publikováno v:
Cell Reports
Autor:
Ekaterina Eremenko, Lior Onn, Shai Kaluski, Thomas Arendt, Debra Toiber, Martina K. Brückner, Monica Einav, Uwe Ueberham, Miguel Portillo, Daniel Stein, Zeev Slobodnik
Several neurodegenerative diseases present Tau accumulation as the main pathological marker. Tau post-translational modifications such as phosphorylation and acetylation are increased in neurodegenerative patients. Here, we show that Tau hyper-acetyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee3d9894f875469e06ca354859dabb1
https://doi.org/10.1101/2020.09.01.276782
https://doi.org/10.1101/2020.09.01.276782
Autor:
Zeev Slobodnik, Daniel Stein, Miguel Portillo, Gal Cleitman, Ido Shirat, Fabian Erdel, Barak Akabayov, Stefan Ilic, Lior Onn, Debra Toiber, Shai Kaluski, Monica Einav
Publikováno v:
eLife
eLife, eLife Sciences Publication, 2020, 9, ⟨10.7554/eLife.51636⟩
'eLife ', vol: 9, pages: e51636-1-e51636-26 (2020)
eLife, Vol 9 (2020)
eLife, eLife Sciences Publication, 2020, 9, ⟨10.7554/eLife.51636⟩
'eLife ', vol: 9, pages: e51636-1-e51636-26 (2020)
eLife, Vol 9 (2020)
DNA double-strand breaks (DSB) are the most deleterious type of DNA damage. In this work, we show that SIRT6 directly recognizes DNA damage through a tunnel-like structure that has high affinity for DSB. SIRT6 relocates to sites of damage independent
Autor:
Zeev Slobodnik, Debra Toiber, Daniel Stein, Lior Onn, Gal Cleitman, Monica Einav, Miguel Portillo, Barak Akabayov, Fabian Erdel, Stefan Ilic, Shai Kaluski, Ido Shirat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b0fc6ba377eed6bc1ac4e7de6254a0e2
https://doi.org/10.7554/elife.51636.sa2
https://doi.org/10.7554/elife.51636.sa2
Autor:
Daniel Stein, Alfredo Garcia-Venzor, Monica Einav, Zeev Slobodnik, Debra Toiber, Uwe Ueberham, Shai Kaluski, Adam Zaretsky, Miguel Portillo, Martina K. Brückner, Ekaterina Eremenko, Lior Onn, Thomas Arendt
Publikováno v:
Cell Reports. 35:109035
Several neurodegenerative diseases present Tau accumulation as the main pathological marker. Tau post-translational modifications such as phosphorylation and acetylation are increased in neurodegeneration. Here, we show that Tau hyper-acetylation at
Autor:
Daniel Stein, Adi Hendler, Haim Y. Cohen, Dotan Omer, Yana Khukhin, Lior Onn, Miguel Portillo, Amir Aharoni, Debra Toiber, Raz Zarivach, Or Gertman
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Mammalian SIRT6 is a well-studied histone deacetylase that was recently shown to exhibit high protein deacylation activity enabling the removal of long chain fatty acyl groups from proteins. SIRT6 was shown to play key roles in cellular homeostasis b