Mapping molecular determinants of CaV2.2 inhibition by RGK proteins and homologs in Xenopus oocytes

Autor: Yehezkel Sasson, Suraj Subramaniam, Tal Buki, Lior Almagor, Orna Chomsky-Hecht, Moshe Katz, Henry Puhl, Stephen R. Ikeda, Nathan Dascal, Joel A. Hirsch

The CaV1 and CaV2 families of voltage-dependent calcium channels play a crucial role in neurotransmitter release, excitation-contraction and many other cellular processes. Comprised of the membrane pore-forming α1, intracellular β and extracellular

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6f4633255754469a601a056dfbea1220
https://doi.org/10.1101/2022.06.21.496996

Structural insights into the aPKC regulatory switch mechanism of the human cell polarity protein lethal giant larvae 2

Autor: Jingzhi Li, Ivan S. Ufimtsev, Aruna Ayer, Lior Almagor, William I. Weis

Metazoan cell polarity is controlled by a set of highly conserved proteins. Lethal giant larvae (Lgl) functions in apical-basal polarity through phosphorylation-dependent interactions with several other proteins as well as the plasma membrane. Phosph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de5b3cbe884c2906cfb6fd56c9dddc5b
https://europepmc.org/articles/PMC6561149/

Dynamic distinctions in the Na + /Ca 2+ exchanger adopting the inward- and outward-facing conformational states

Autor: Bosmat Refaeli, Petr Man, Liat van Dijk, Moshe Giladi, Eric Forest, Daniel Khananshvili, Lior Almagor, Reuben Hiller

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2017, 292 (29), pp.12311-12323. ⟨10.1074/jbc.M117.787168⟩
Journal of Biological Chemistry, 2017, 292 (29), pp.12311-12323. ⟨10.1074/jbc.M117.787168⟩

International audience; Na(+)/Ca(2+) exchanger (NCX) proteins operate through the alternating access mechanism, where the ion-binding pocket is exposed in succession either to the extracellular or the intracellular face of the membrane. The archaeal

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db149f8e673c6fd57bdf26a6166aeece
https://hal.archives-ouvertes.fr/hal-01647025

Functional asymmetry of bidirectional Ca2+-movements in an archaeal sodium–calcium exchanger (NCX_Mj)

Autor: Liat van Dijk, Reuben Hiller, Moshe Giladi, Tal Buki, Daniel Khananshvili, Lior Almagor

Publikováno v: Cell Calcium. 56:276-284

Dynamic features of Ca(2+) interactions with transport and regulatory sites control the Ca(2+)-fluxes in mammalian Na(+)/Ca(2+)(NCX) exchangers bearing the Ca(2+)-binding regulatory domains on the cytosolic 5L6 loop. The crystal structure of Methanoc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9831aa4226d0f384b22539acc91df1f7
https://doi.org/10.1016/j.ceca.2014.08.010

Asymmetric Preorganization of Inverted Pair Residues in the Sodium-Calcium Exchanger

Autor: Moshe Giladi, Petr Man, Eric Forest, Daniel Khananshvili, Liat van Dijk, Lior Almagor, Reuben Hiller

Publikováno v: Scientific Reports
Scientific Reports, Nature Publishing Group, 2016, 6, ⟨10.1038/srep20753⟩
Scientific Reports, 2016, 6, ⟨10.1038/srep20753⟩

In analogy with many other proteins, Na+/Ca2+ exchangers (NCX) adapt an inverted twofold symmetry of repeated structural elements, while exhibiting a functional asymmetry by stabilizing an outward-facing conformation. Here, structure-based mutant ana

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::afc67815c07c092a6db7fe8b8891ff30
https://hal.archives-ouvertes.fr/hal-01299020