Resolving candidate genes of mouse skeletal muscle QTL via RNA-Seq and expression network analyses

Autor: Lionikas Arimantas, Meharg Caroline, Derry Jonathan MJ, Ratkevicius Aivaras, Carroll Andrew M, Vandenbergh David J, Blizard David A

Publikováno v: BMC Genomics, Vol 13, Iss 1, p 592 (2012)

Abstract Background We have recently identified a number of Quantitative Trait Loci (QTL) contributing to the 2-fold muscle weight difference between the LG/J and SM/J mouse strains and refined their confidence intervals. To facilitate nomination of

Externí odkaz: https://doaj.org/article/1e27fb1dd678454dab69b460b71f9a23

Stanniocalcin‐2 inhibits skeletal muscle growth and is upregulated in functional overload‐induced hypertrophy

Autor: Arimantas Lionikas, Ana I. Hernandez Cordero, Audrius Kilikevicius, Andrew M. Carroll, Guy S. Bewick, Lutz Bunger, Aivaras Ratkevicius, Lora K. Heisler, Mette Harboe, Claus Oxvig

Publikováno v: Physiological Reports, Vol 11, Iss 15, Pp n/a-n/a (2023)

Abstract Aims Stanniocalcin‐2 (STC2) has recently been implicated in human muscle mass variability by genetic analysis. Biochemically, STC2 inhibits the proteolytic activity of the metalloproteinase PAPP‐A, which promotes muscle growth by upregul

Externí odkaz: https://doaj.org/article/e1ba6f02377348389e9a1a242859a575

Stanniocalcin‐2 inhibits skeletal muscle growth and is upregulated in functional overload‐induced hypertrophy.

Autor: Lionikas, Arimantas¹ (AUTHOR) a.lionikas@abdn.ac.uk, Hernandez Cordero, Ana I.² (AUTHOR), Kilikevicius, Audrius³ (AUTHOR), Carroll, Andrew M.⁴ (AUTHOR), Bewick, Guy S.¹ (AUTHOR), Bunger, Lutz⁵ (AUTHOR), Ratkevicius, Aivaras³ (AUTHOR), Heisler, Lora K.¹ (AUTHOR), Harboe, Mette⁶ (AUTHOR), Oxvig, Claus⁶ (AUTHOR)

Publikováno v: Physiological Reports. Aug2023, Vol. 11 Issue 15, p1-12. 12p.

Genome wide association analysis in a mouse advanced intercross line

Autor: Natalia M. Gonzales, Jungkyun Seo, Ana I. Hernandez Cordero, Celine L. St. Pierre, Jennifer S. Gregory, Margaret G. Distler, Mark Abney, Stefan Canzar, Arimantas Lionikas, Abraham A. Palmer

Publikováno v: Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)

Multigenerational outbred populations from an advanced intercross line (AIL) of mice represent useful resources for genome wide association analysis. Here, the authors analyze 1,063 LG x SM AIL mice to identify significant associations for 50 traits

Externí odkaz: https://doaj.org/article/b9f3f59ed9014b36ad09966559d40fb1

Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility

Autor: Arimantas Lionikas, Jerome Nicod, Abraham A. Palmer, Jonathan Flint, Clarissa C. Parker, Na Cai, Robert W. Davies, Richard Mott, Shyam Gopalakrishnan, Jennifer Zou

Publikováno v: Zou, J, Gopalakrishnan, S, Parker, C C, Nicod, J, Mott, R, Cai, N, Lionikas, A, Davies, R W, Palmer, A A & Flint, J 2022, ' Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility ', G3: Genes, Genomes, Genetics, vol. 12, no. 1, jkab394 . https://doi.org/10.1093/g3journal/jkab394
G3: Genes, Genomes, Genetics, Vol 12, Iss 1 (2021)
G3: Genes|Genomes|Genetics

Combining samples for genetic association is standard practice in human genetic analysis of complex traits, but is rarely undertaken in rodent genetics. Here, using 23 phenotypes and genotypes from two independent laboratories, we obtained a sample s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee96099f98797c794846aadc6c80ec8b
https://curis.ku.dk/portal/da/publications/analysis-of-independent-cohorts-of-outbred-cfw-mice-reveals-novel-loci-for-behavioral-and-physiological-traits-and-identifies-factors-determining-reproducibility(cf201eff-1196-49ea-b7f6-c2d3fa44ab7e).html