Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lionello Ruggeri"'
Autor:
Giuseppe Maio, Lionello Ruggeri, Cristiano Scottà, Anna Rosa Garbuglia, Vincenzo Mellace, Maria Paola Perrone, Patrizia Maio, Maria Rosaria Capobianchi, Nicola Gargano, Paola Del Porto, Enea Spada, Silvia Guglietta, Antonella Folgori, Cristina Camperio, Enza Piccolella, Leonidas Salichos
Publikováno v:
Virology. 386(2):398-406
The ability of HCV to mutate in response to cytotoxic T lymphocyte (CTL) pressure is increasingly recognized, but the influence of such a mechanism in viral persistence and final disease outcome has not been ascertained. In this study, we performed a
Autor:
Marco Mattu, Carl P. Sparrow, Matthew J. Bottomley, Joseph C. Santoro, Lionello Ruggeri, Fabio Talamo, Paola Lo Surdo, Jennifer Baysarowich, Richard T. Cummings, Rose M. Cubbon, Raffaele De Francesco, Laura Orsatti, Ayesha Sitlani, Alessandra Calzetta, Andrea Carfi, A. Noto, Timothy S. Fisher, Agostino Cirillo
Publikováno v:
Journal of Biological Chemistry. 284:1313-1323
PCSK9 regulates low density lipoprotein receptor (LDLR) levels and consequently is a target for the prevention of atherosclerosis and coronary heart disease. Here we studied the interaction, of LDLR EGF(A/AB) repeats with PCSK9. We show that PCSK9 bi
Autor:
Alfonso Mele, Maria Paola Perrone, Anna Rosa Garbuglia, Antonella Folgori, Enea Spada, Gabriella Girelli, Enza Piccolella, Alfredo Nicosia, Cristiano Scottà, Lionello Ruggeri, Paola Del Porto, Luca Laurenti, Maria Rosaria Capobianchi
Publikováno v:
Journal of Hepatology. 48:216-228
Background/Aims: Several studies suggest that the evolutionary rate of HVR1 sequence in acute HCV hepatitis derives from the action of a continuous immune-driven positive selection. However, these studies have not been performed examining the relatio
Autor:
Fatma Abdel-Aziz, Alfredo Nicosia, Sayed F. Abdelwahab, Alfred M. Prince, Sonia K. Stoszek, Antonella Folgori, G. Thomas Strickland, Ahmed Osman, Nabiel Mikhail, Mohamed Abdel-Hamid, Lionello Ruggeri, Maged M. Al-Sherbiny, Nahla Mohamed, Mohamed T. Shata
Publikováno v:
Scopus-Elsevier
Sporadic cases of cell-mediated immunity (CMI) in persons exposed to hepatitis C (HCV) but evidently uninfected have been reported. To further define this, we measured CMI in individuals without evidence of HCV infection, that is, negative for HCV-an
Autor:
Joseph C. Santoro, Sookhee Ha, Paola Lo Surdo, Rose M. Cubbon, Anka G. Ehrhardt, Xun Shen, Dale Lewis, Richard T. Cummings, Douglas Wisniewski, Yan G. Ni, Brian K. Hubbard, Lionello Ruggeri, Matthew J. Bottomley, Jon H. Condra, Shilpa Pandit, Leila Njimoluh, Cinzia Volpari, Stefania Di Marco, Laura Orsatti, A. Noto, Holly A. Hammond, Timothy S. Fisher, Dana D. Wood, Ayesha Sitlani, Andrea Carfi
Publikováno v:
The Journal of biological chemistry. 285(17)
PCSK9 binds to the low density lipoprotein receptor (LDLR) and leads to LDLR degradation and inhibition of plasma LDL cholesterol clearance. Consequently, the role of PCSK9 in modulating circulating LDL makes it a promising therapeutic target for tre
Autor:
Vincenzo La Mura, Raffaella Vecchione, Silverio Perrotta, A. Folgori, Lionello Ruggeri, A. Nicosia, Eliana Persico, Roberto Torella, Mario Masarone, Marcello Persico, L. Terracciano
Publikováno v:
Journal of viral hepatitis. 13(5)
Some chronic hepatitis C (CHC) patients exhibit persistently normal alanine aminotransferase (ALT) levels (PNAL). Patients with PNAL experience significantly milder disease. In order to understand the differences between CHC patients with elevated AL
Autor:
Rosalba Tafi, Alessandra Vitelli, Alfredo Nicosia, Riccardo Cortese, Tong-Ming Fu, Monica Pezzanera, Andrew J. Bett, Stefano Colloca, Stefania Capone, Antonella Folgori, Lionello Ruggeri, Annalisa Meola, Claudia Santini, Bruno Bruni Ercole, Mary Ellen Davies, Alessandra Luzzago
Publikováno v:
Journal of virology. 80(4)
Success in resolving hepatitis C virus (HCV) infection has been correlated to vigorous, multispecific, and sustained CD8 + T-cell response in humans and chimpanzees. The efficacy of inducing T-cell-mediated immunity by recombinant serotype 5 adenovir
Autor:
Lionello Ruggeri, Riccardo Cortese, Maria Paola Perrone, P. Del Porto, Alfonso Mele, Alessandra Vitelli, Anna Rosa Garbuglia, Antonella Folgori, Alfredo Nicosia, Enea Spada, Monica Pezzanera, Enza Piccolella
Background and aims: Cellular mediated immunity (CMI) is thought to play a key role in resolution of primary hepatitis C virus (HCV) infection. However, CD4 + and CD8 + T cell responses are also generated during acute infection in individuals who bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fb48bcc3a49221951fb6e865208712f
http://hdl.handle.net/11588/477416
http://hdl.handle.net/11588/477416
Autor:
Enea Spada, Silvia Guglietta, Lionello Ruggeri, Alfonso Mele, Luca Laurenti, Alessandra Vitelli, Gloria Taliani, Maria Rosaria Capobianchi, Enza Piccolella, Paola Del Porto, Cristiano Scottà, Alfredo Nicosia, Valentina Pacciani, Anna Rosa Garbuglia, Antonella Folgori, Maria Paola Perrone
Publikováno v:
European journal of immunology. 35(9)
Cellular immune responses are induced during hepatitis C virus (HCV) infection and acute-phase CD8(+) T cells are supposed to play an important role in controlling viral replication. In chimpanzees, failure of CD8(+) T cells to control HCV replicatio
Autor:
Lionello Ruggeri, Alessandra Vitelli, Alfredo Nicosia, Armin Lahm, Elena Fattori, Alessandra Luzzago, Stefania Capone, Elisabetta Sporeno, Rosalba Tafi, Antonella Folgori, Stefano Colloca, Monica Pezzanera, Riccardo Cortese, Annalisa Meola, Mirko Arcuri, Bruno Bruni Ercole
Publikováno v:
Nature medicine. 12(2)
Three percent of the world's population is chronically infected with the hepatitis C virus (HCV) and at risk of developing liver cancer. Effective cellular immune responses are deemed essential for spontaneous resolution of acute hepatitis C and long