Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lionel Sacconnay"'
Autor:
Badiaa Bouzya, Ronan Nicolas Rouxel, Lionel Sacconnay, Romuald Mascolo, Laurence Nols, Stéphanie Quique, Loïc François, Anne Atas, Lucile Warter, Nancy Dezutter, Clarisse Lorin
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-10 (2023)
Abstract Respiratory syncytial virus (RSV) causes a high disease burden in older adults. An effective vaccine for this RSV-primed population may need to boost/elicit robust RSV-neutralizing antibody responses and recall/induce RSV-specific T cell res
Externí odkaz:
https://doaj.org/article/17f35366397049d4a12065cb28b093f2
Autor:
Lionel Sacconnay, Melissa Angleviel, Giuseppe Marco Randazzo, Marcos Marçal Ferreira Queiroz, Emerson Ferreira Queiroz, Jean-Luc Wolfender, Pierre-Alain Carrupt, Alessandra Nurisso
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 8, Iss 2, p e2689 (2014)
BACKGROUND: The silent-information regulator 2 proteins, otherwise called sirtuins, are currently considered as emerging anti-parasitic targets. Nicotinamide, a pan-sirtuin inhibitor, is known to cause kinetoplast alterations and the arrested growth
Externí odkaz:
https://doaj.org/article/f704bf9983f84b8698f64c03a2e2ad8a
Autor:
Carolina dos Santos Passos, Pierre-Alain Carrupt, Daumantas Matulis, Alessandra Nurisso, Jelena Jachno, Lucie Ryckewaert, Claudia A. Simões-Pires, Lionel Sacconnay, Giuseppe Marco Randazzo, Vilma Michailovienė, Asta Zubrienė, Charlotte Petit
Publikováno v:
European Journal of Pharmaceutical Sciences. 85:59-67
Sirtuins (SIRTs) are a family of enzymes able to catalyze the deacetylation of the N-acetyl lysines of both histone and non-histone substrates. Inhibition of SIRTs catalytic activity was recently reported in the literature as being beneficial in huma
Autor:
Pierre-Alain Carrupt, Alessandra Nurisso, Lucie Ryckewaert, Lionel Sacconnay, Claudia A. Simões-Pires
Publikováno v:
Toxicology Letters. 229:374-380
Ginkgolic acids and urushiols are natural alkylphenols known for their mutagenic, carcinogenic and genotoxic potential. However, the mechanism of toxicity of these compounds has not been thoroughly elucidated so far. Considering that the SIRT inhibit
Autor:
Claudia A. Simões-Pires, Lucília Kato, Lionel Sacconnay, Maria Cristina Guerra, Lucie Ryckewaert, Cma de Oliveira, Alessandra Nurisso, Carolina dos Santos Passos
Publikováno v:
Planta Medica. 81
Autor:
Carolina dos Santos Passos, Lucie Ryckewaert, Amélia T. Henriques, Claudia A. Simões-Pires, Cecília M. A. de Oliveira, Lucilia Kato, Pierre-Alain Carrupt, Maria Cristina Guerra, Alessandra Nurisso, Lionel Sacconnay
Publikováno v:
Planta medica. 81(6)
Epigenetic enzymes such as histone deacetylases play a crucial role in the development of ageing-related diseases. Among the 18 histone deacetylase isoforms found in humans, class III histone deacetylases, also known as sirtuins, seem to be promising
Autor:
Alessandra Nurisso, Pierre-Alain Carrupt, Marcos Marçal Ferreira Queiroz, Jean-Luc Wolfender, Lionel Sacconnay, Melissa Angleviel, Giuseppe Marco Randazzo, Emerson Ferreira Queiroz
Publikováno v:
PLoS Neglected Tropical Diseases
PLoS Neglected Tropical Diseases, Vol 8, Iss 2, p e2689 (2014)
PLOS Neglected Tropical Diseases, Vol. 8, No 2 (2014) P. e2689
PLoS Neglected Tropical Diseases, Vol 8, Iss 2, p e2689 (2014)
PLOS Neglected Tropical Diseases, Vol. 8, No 2 (2014) P. e2689
Background The silent-information regulator 2 proteins, otherwise called sirtuins, are currently considered as emerging anti-parasitic targets. Nicotinamide, a pan-sirtuin inhibitor, is known to cause kinetoplast alterations and the arrested growth o
Autor:
Lionel Sacconnay, Alessandra Nurisso, Despina Smirlis, Pierre-Alain Carrupt, Emerson Ferreira Queiroz, Milena Botelho Perreira Soares, Jean L. Wolfender
Publikováno v:
Molecular bioSystems. 9(9)
Trypanosoma cruzi and Leishmania spp. are protozoan pathogens responsible for Chagas disease and leishmaniasis, respectively. Current therapies rely only on a very small number of drugs, most of them are inadequate because of their severe host toxici
Publikováno v:
Journal of Structural Biology
In recent years, sirtuins (SIRTs), members of histone deacetylases (HDACs) class III, have been found to modulate cellular processes related to the development of human aging-related pathologies (i.e. cancer, neurodegeneration, metabolic disorders).