Zobrazeno 1 - 10
of 63
pro vyhledávání: '"Lionel Pintard"'
Autor:
Jessica Knox, Nicolas Joly, Edmond M. Linossi, José A. Carmona-Negrón, Natalia Jura, Lionel Pintard, William Zuercher, Peter J. Roy
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-19 (2021)
Abstract Over one billion people are currently infected with a parasitic nematode. Symptoms can include anemia, malnutrition, developmental delay, and in severe cases, death. Resistance is emerging to the anthelmintics currently used to treat nematod
Externí odkaz:
https://doaj.org/article/d0e282a9e8e24d77b3d9aefd33a45006
Publikováno v:
eLife, Vol 11 (2022)
Previously, we reported that the Polo-like kinase PLK-1 phosphorylates the single Caenorhabditis elegans lamin (LMN-1) to trigger lamina depolymerization during mitosis. We showed that this event is required to form a pronuclear envelope scission eve
Externí odkaz:
https://doaj.org/article/27475636f13b4fe497719e47009e19e2
Autor:
Ilektra Kouranti, Waed Abdel Khalek, Stephani Mazurkiewicz, Irmine Loisel-Ferreira, Alexis M. Gautreau, Lionel Pintard, Xavier Jeunemaitre, Eric Clauser
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 9, p 5151 (2022)
Cullin 3 (CUL3) is the scaffold of Cullin3 Ring E3-ligases (CRL3s), which use various BTB-adaptor proteins to ubiquitinate numerous substrates targeting their proteasomal degradation. CUL3 mutations, responsible for a severe form of familial hyperkal
Externí odkaz:
https://doaj.org/article/df16924b81fd48c9b4988f7b209e66ad
Autor:
Griselda Velez-Aguilera, Sylvia Nkombo Nkoula, Batool Ossareh-Nazari, Jana Link, Dimitra Paouneskou, Lucie Van Hove, Nicolas Joly, Nicolas Tavernier, Jean-Marc Verbavatz, Verena Jantsch, Lionel Pintard
Publikováno v:
eLife, Vol 9 (2020)
Life of sexually reproducing organisms starts with the fusion of the haploid egg and sperm gametes to form the genome of a new diploid organism. Using the newly fertilized Caenorhabditis elegans zygote, we show that the mitotic Polo-like kinase PLK-1
Externí odkaz:
https://doaj.org/article/2a846be5f188463186513102ddc7b563
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 6, Iss 10, Pp 3431-3442 (2016)
Cullin-RING E3-Ligases (CRLs), the largest family of E3 ubiquitin-Ligases, regulate diverse cellular processes by promoting ubiquitination of target proteins. The evolutionarily conserved Leucine Rich Repeat protein 1 (LRR-1) is a substrate-recogniti
Externí odkaz:
https://doaj.org/article/4b84a52a943f4da1a436998274c9a4f9
Autor:
Yann Thomas, Luca Cirillo, Costanza Panbianco, Lisa Martino, Nicolas Tavernier, Françoise Schwager, Lucie Van Hove, Nicolas Joly, Anna Santamaria, Lionel Pintard, Monica Gotta
Publikováno v:
Cell Reports, Vol 15, Iss 3, Pp 510-518 (2016)
The conserved Bora protein is a Plk1 activator, essential for checkpoint recovery after DNA damage in human cells. Here, we show that Bora interacts with Cyclin B and is phosphorylated by Cyclin B/Cdk1 at several sites. The first 225 amino acids of B
Externí odkaz:
https://doaj.org/article/924201aa600c4cd9aa9a611934c30191
Autor:
Lionel Pintard, Vincent Archambault
Publikováno v:
Open Biology, Vol 8, Iss 8 (2018)
The Polo kinase is an essential regulator of cell division. Its ability to regulate multiple events at distinct subcellular locations and times during mitosis is remarkable. In the last few years, a much clearer mechanistic understanding of the funct
Externí odkaz:
https://doaj.org/article/aea2818e4e874358a3182773560d06c8
Autor:
Silvia Gutnik, Yann Thomas, Yanwu Guo, Janosch Stoecklin, Anca Neagu, Lionel Pintard, Jorge Merlet, Rafal Ciosk
Publikováno v:
Biology Open, Vol 7, Iss 7 (2018)
The Notch signalling pathway is a conserved and widespread signalling paradigm, and its misregulation has been implicated in numerous disorders, including cancer. The output of Notch signalling depends on the nuclear accumulation of the Notch recepto
Externí odkaz:
https://doaj.org/article/a97deb6571094184b91de9c9b335e6e2
Autor:
Julien Burger, Jorge Merlet, Nicolas Tavernier, Bénédicte Richaudeau, Andreas Arnold, Rafal Ciosk, Bruce Bowerman, Lionel Pintard
Publikováno v:
PLoS Genetics, Vol 9, Iss 3, p e1003375 (2013)
The ubiquitin-proteolytic system controls the stability of proteins in space and time. In this study, using a temperature-sensitive mutant allele of the cul-2 gene, we show that CRL2(LRR-1) (CUL-2 RING E3 ubiquitin-ligase and the Leucine Rich Repeat
Externí odkaz:
https://doaj.org/article/79cbc2099e0f404d888adb3b5d25e4fd
Publikováno v:
Open Biology, Vol 3, Iss 8 (2013)
Spatio-temporal coordination of events during cell division is crucial for animal development. In recent years, emerging data have strengthened the notion that tight coupling of cell cycle progression and cell polarity in dividing cells is crucial fo
Externí odkaz:
https://doaj.org/article/fff288e691aa4a71b7388fd714692796