Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Lionel Muller"'
Publikováno v:
Frontiers in Aging Neuroscience, Vol 8 (2016)
Frontotemporal Dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two neurodegenerative diseases associated to mislocalization and aggregation of TAR DNA-binding protein 43 (TDP-43). To investigate in depth the behavioral phenotype associated
Externí odkaz:
https://doaj.org/article/ccaf5a0329dc4a489fc99bd681437fa1
Autor:
Naomi N. K. Kreamer, Rajiv Chopra, Ruth E. Caughlan, Doriano Fabbro, Eric Fang, Patricia Gee, Ian Hunt, Min Li, Barbara C. Leon, Lionel Muller, Brian Vash, Angela L. Woods, Travis Stams, Charles R. Dean, Tsuyoshi Uehara
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Externí odkaz:
https://doaj.org/article/a4e35beabe6845109a733f8dfc8a0e04
Autor:
Allan D'Arcy, Nikolaus Schiering, Cary Fridrich, Yu-Hsin Chiu, Donglei Liu, Micah Hollis-Symynkywicz, Edwige Lorthiois, Hyungchul Kim, Darija Dedic, Richard Sedrani, Rose Mo, Solene Dussauge, Calhoun Amy, Stefanie Harlfinger, Treeve Currie, Simon Ruedisser, Lionel Muller, Rohit Duvadie, Ulrich Hassiepen, Adelaide Druet, Louise Kirman, Jason Elliott, Kenji Namoto, Gabriela Monnet, Francesca Perruccio, Paul Ramage, Eva Altmann, David Louis Feldman, Fabien Tritsch, Xueming Huang, Joerg Berghausen, Tanzina Fazal, Richard Zessis, James Roache, Eric T Williams, Christopher M. Adams, Wilhelm A. Weihofen, Viktor Hornak, Peter Delgado, Peter Hoffmann, David Barnes-Seeman, Douglas Bevan, ShuangXi Wang, Hong Liu, Martin Renatus, Celine Dentel, Corinne Durand, Juergen Klaus Maibaum, Guiqing Liang, Kamal Fettis, Gordon Turner, Rajeshri Ganesh Karki, Loren Lindsley, Julie Lachal, Andreas Hein
Publikováno v:
Journal of medicinal chemistry. 63(15)
The serine protease Factor XI (FXI) is a prominent drug target as it holds promise to deliver efficacious anti-coagulation without an enhanced risk of major bleeds. Several efforts have been described targeting the active form of the enzyme, FXIa. He
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d2ad110af1ecb6144e75a9298044b57
https://pubmed.ncbi.nlm.nih.gov/32551603
https://pubmed.ncbi.nlm.nih.gov/32551603
Autor:
Brian Edward Vash, Naomi N. K. Kreamer, Lionel Muller, Ian Hunt, Tsuyoshi Uehara, Charles R. Dean, Patricia Gee, Ruth E. Caughlan, Barbara C. Leon, Doriano Fabbro, Angela L. Woods, Eric Fang, Min Li, Travis Stams, Rajiv Chopra
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-12 (2018)
Scientific Reports
Scientific Reports
Phosphorylation of Pseudomonas aeruginosa lipopolysaccharide (LPS) is important for maintaining outer membrane integrity and intrinsic antibiotic resistance. We solved the crystal structure of the LPS heptose kinase WaaP, which is essential for growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6cbb89d2d9aab83b40fcb64277a89324
http://link.springer.com/article/10.1038/s41598-018-32379-1
http://link.springer.com/article/10.1038/s41598-018-32379-1
Autor:
Tania Panigada, Rosalba Mansi, Damian Wild, Ulrich Hassiepen, Christof Rottenburger, Lionel Muller, Anna-Maria Wild, Melpomeni Fani, Alexander W. Sauter, Stefan Wiehr, Martin Béhé, Susanne Geistlich
Publikováno v:
Journal of Nuclear Medicine. 60:393-399
393 Objectives: The currently available PET tracers i.e. 18F-FET and 11C-methionine have proven high diagnostic efficacy in GBM. However, the development of SPECT based tracers is always viewed as a cost-effective alternate to PET imaging. The aim of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0e396b1bf73ddeb1c3e700ff094a6338
https://doi.org/10.2967/jnumed.118.207845
https://doi.org/10.2967/jnumed.118.207845
Autor:
Daniel Huster, Gerd Anders, Sergey A. Samsonov, Lionel Muller, Tania Panigada, Stephan Theisgen, Stephan Heymann, Ulrich Hassiepen
Publikováno v:
IEEE/ACM Transactions on Computational Biology and Bioinformatics. 15:300-308
Interleukin-8 (IL-8, CXCL8) is a neutrophil chemotactic factor belonging to the family of chemokines. IL-8 was shown to resist pepsin cleavage displaying its high resistance to this protease. However, the molecular mechanisms underlying this resistan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::470d6577321a14bce9144bbbc2b63981
https://doi.org/10.1109/tcbb.2016.2614821
https://doi.org/10.1109/tcbb.2016.2614821
Autor:
Meike Scharenberg, Serge Côté, Carsten Krantz, Craig T. Basson, Keith DiPetrillo, Stefan Ewert, Janeen M Salter, Brian Stoll, Geraldine Horny, Simone Schleeger, Yu-Hsin Chiu, Julie DeGagne, Peter Hoffmann, Andreas Hein, Jianying Yu, Peter McCormack, Zhiping Chen, Paul Ramage, Nikolaus Schiering, Frederic Villard, Yasser Khder, Samu Melkko, Jörg Eder, Ulrich Hassiepen, Yiming Zhang, Lionel Muller, Xueming Huang, Robert J. A. Frost, Kenneth Kulmatycki, Alexander W. Koch, David Louis Feldman
Publikováno v:
Blood. 133(13)
A large unmet medical need exists for safer antithrombotic drugs because all currently approved anticoagulant agents interfere with hemostasis, leading to an increased risk of bleeding. Genetic and pharmacologic evidence in humans and animals suggest
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f8d1cd3f39c4c75c6b009bf317a08d
https://pubmed.ncbi.nlm.nih.gov/30923107
https://pubmed.ncbi.nlm.nih.gov/30923107
Autor:
Alexander W, Sauter, Rosalba, Mansi, Ulrich, Hassiepen, Lionel, Muller, Tania, Panigada, Stefan, Wiehr, Anna-Maria, Wild, Susanne, Geistlich, Martin, Béhé, Christof, Rottenburger, Damian, Wild, Melpomeni, Fani
Publikováno v:
Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 60(3)
Patients with metastatic medullary thyroid cancer (MTC) have limited systemic treatment options. The use of radiolabeled gastrin analogs targeting the cholecystokinin-2 receptor (CCK2R) is an attractive approach. However, their therapeutic efficacy i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::866be9795caf40ac53b42d694f99960e
https://pubmed.ncbi.nlm.nih.gov/30002107
https://pubmed.ncbi.nlm.nih.gov/30002107
Autor:
Barbara C. Leon, Tsuyoshi Uehara, Lionel Muller, Rajiv Chopra, Ian Hunt, Angela L. Woods, Naomi N. K. Kreamer, Ruth E. Caughlan, Doriano Fabbro, Charles R. Dean, Patricia Gee, Eric Fang, Brian Edward Vash, Travis Stams, Min Li
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-1 (2018)
Scientific Reports
Scientific Reports
Phosphorylation of Pseudomonas aeruginosa lipopolysaccharide (LPS) is important for maintaining outer membrane integrity and intrinsic antibiotic resistance. We solved the crystal structure of the LPS heptose kinase WaaP, which is essential for growt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fb77b96dac0da5a41c9a7ad1de55f0
https://doaj.org/article/a4e35beabe6845109a733f8dfc8a0e04
https://doaj.org/article/a4e35beabe6845109a733f8dfc8a0e04
Publikováno v:
In Alzheimer's & Dementia: The Journal of the Alzheimer's Association July 2019 15(7) Supplement:P543-P544