Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Lionel Mignion"'
Autor:
Natacha Dehaen, Matthias Van Hul, Lionel Mignion, Axell-Natalie Kouakou, Patrice D. Cani, Bénédicte F. Jordan
Publikováno v:
Heliyon, Vol 10, Iss 13, Pp e33356- (2024)
Bioluminescence imaging has become an essential non-invasive tool in cancer research for monitoring various cellular processes and tumor progression in vivo. In this article, we aimed to propose a transduction and selection protocol for reliable in v
Externí odkaz:
https://doaj.org/article/bd953095698448778942fe3c0e0d1cf4
Autor:
Benoit J Van den Eynde, Bernard Gallez, Veronica Finisguerra, Tereza Dvorakova, Matteo Formenti, Pierre Van Meerbeeck, Lionel Mignion
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss 5 (2023)
Background Despite their revolutionary success in cancer treatment over the last decades, immunotherapies encounter limitations in certain tumor types and patients. The efficacy of immunotherapies depends on tumor antigen-specific CD8 T-cell viabilit
Externí odkaz:
https://doaj.org/article/1d2e67c9b46f48c985ed830f6db08c69
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 3, p 1725 (2024)
There is currently no consensus to determine which advanced melanoma patients will benefit from targeted therapy, immunotherapy, or a combination of both, highlighting the critical need to identify early-response biomarkers to advanced melanoma thera
Externí odkaz:
https://doaj.org/article/6ab8f2ce7c5d40eeab83bc859fbd898b
Autor:
Chantale Farah, Marie-Aline Neveu, Caroline Bouzin, Zorica Knezevic, Bernard Gallez, Eleonora Leucci, Jean-François Baurain, Lionel Mignion, Bénédicte F. Jordan
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 2499 (2023)
There is currently no consensus to determine which advanced melanoma patients will benefit from immunotherapy, highlighting the critical need to identify early-response biomarkers to immune checkpoint inhibitors. The aim of this work was to evaluate
Externí odkaz:
https://doaj.org/article/a2610fa280c0407a8ef37b9170a7be95
Autor:
Donatienne d’Hose, Lionel Mignion, Loïc Hamelin, Pierre Sonveaux, Bénédicte F. Jordan, Bernard Gallez
Publikováno v:
Biomolecules, Vol 12, Iss 10, p 1418 (2022)
Background: Because statins were found to decrease the oxygen consumption rate (OCR) of a variety of normal cells, our hypothesis was that statins may also decrease the OCR of cancer cells, alleviate tumor hypoxia and radiosensitize tumors. Methods:
Externí odkaz:
https://doaj.org/article/74701f1ef94c47eaaec74a27fc7f8914
Autor:
Donatienne d’Hose, Barbara Mathieu, Lionel Mignion, Micael Hardy, Olivier Ouari, Bénédicte F. Jordan, Pierre Sonveaux, Bernard Gallez
Publikováno v:
Molecules, Vol 27, Iss 18, p 5872 (2022)
Background: Mito-metformin10 (MM10), synthesized by attaching a triphenylphosphonium cationic moiety via a 10-carbon aliphatic side chain to metformin, is a mitochondria-targeted analog of metformin that was recently demonstrated to alter mitochondri
Externí odkaz:
https://doaj.org/article/726691a89ff04067a14a84ede0d25ed5
Autor:
Chloe Buyse, Nicolas Joudiou, Aude Warscotte, Elena Richiardone, Lionel Mignion, Cyril Corbet, Bernard Gallez
Publikováno v:
Metabolites, Vol 12, Iss 6, p 557 (2022)
Extracellular acidification has been shown to be an important characteristic of invasive tumors, as it promotes invasion and migration but also resistance to treatments. Targeting transporters involved in the regulation of tumor pH constitutes a prom
Externí odkaz:
https://doaj.org/article/80e3f8cb6ee8489897c939967df4068a
Autor:
Chantale Farah, Marie-Aline Neveu, Caner Yelek, Caroline Bouzin, Bernard Gallez, Jean-François Baurain, Lionel Mignion, Bénédicte F. Jordan
Publikováno v:
Biomedicines, Vol 10, Iss 3, p 717 (2022)
A vast majority of BRAF V600E mutated melanoma patients will develop resistance to combined BRAF/MEK inhibition after initial clinical response. Resistance to targeted therapy is described to be accompanied by specific metabolic changes in melanoma.
Externí odkaz:
https://doaj.org/article/6e088763fec0472cab56a9ad05993343
Autor:
Cyril Corbet, Estelle Bastien, Nihed Draoui, Bastien Doix, Lionel Mignion, Bénédicte F. Jordan, Arnaud Marchand, Jean-Christophe Vanherck, Patrick Chaltin, Olivier Schakman, Holger M. Becker, Olivier Riant, Olivier Feron
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
Tumor cells can fuel their metabolism with lactate. Here the authors show that inhibition of mitochondrial pyruvate carrier (MPC) blocks extracellular lactate uptake by promoting intracellular pyruvate accumulation and inhibits oxidative metabolism,
Externí odkaz:
https://doaj.org/article/11c35a245c4e4c128676d165835a54e9
Autor:
Federica Cappellesso, Marie-Pauline Orban, Niranjan Shirgaonkar, Emanuele Berardi, Jens Serneels, Marie-Aline Neveu, Daria Di Molfetta, Francesca Piccapane, Rosa Caroppo, Lucantonio Debellis, Tessa Ostyn, Nicolas Joudiou, Lionel Mignion, Elena Richiardone, Bénédicte F. Jordan, Bernard Gallez, Cyril Corbet, Tania Roskams, Ramanuj DasGupta, Sabine Tejpar, Mario Di Matteo, Daniela Taverna, Stephan J. Reshkin, Baki Topal, Federico Virga, Massimiliano Mazzone
Publikováno v:
Nature Cancer, Vol. 3, p. 1464-1483 (2022)
Solid tumors are generally characterized by an acidic tumor microenvironment (TME) that favors cancer progression, therapy resistance and immune evasion. By single-cell RNA-sequencing analysis in individuals with pancreatic ductal adenocarcinoma (PDA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be2da78e9924fb0bc0407de8ed998830
https://lirias.kuleuven.be/handle/20.500.12942/712182
https://lirias.kuleuven.be/handle/20.500.12942/712182