Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lionel M. Igaz"'
Publikováno v:
Frontiers in Cellular Neuroscience, Vol 14 (2020)
TDP-43 is a major component of cytoplasmic inclusions observed in neurodegenerative diseases like frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). To further understand the role of TDP-43 in mRNA/protein metabolism and proteosta
Externí odkaz:
https://doaj.org/article/7f9376e9fb674c3c9e934d6c9ffb6a87
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Dysregulation of TAR DNA-binding protein 43 (TDP-43) is a hallmark feature of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS), two fatal neurodegenerative diseases. TDP-43 is a ubiquitously expressed RNA-binding protein with man
Externí odkaz:
https://doaj.org/article/27f662a824ac4b0e85cad86de87453d1
Autor:
Victoria S. B. Wies Mancini, Anabella A. Di Pietro, Soledad Olmos, Pablo Silva Pinto, Marianela Vence, Mariel Marder, Lionel M. Igaz, María S. Marcora, Juana M. Pasquini, Jorge D. Correale, Laura A. Pasquini
Publikováno v:
Journal of Neurochemistry. 160:643-661
Multiple sclerosis (MS), especially in its progressive phase, involves early axonal and neuronal damage resulting from a combination of inflammatory mediators, demyelination, and loss of trophic support. During progressive disease stages, a microenvi
Autor:
Bruno Gabriel Berardino, Lionel M. Igaz, Mariela Chertoff, Fabricio Matias Ballarini, Eduardo T. Cánepa
Publikováno v:
Nutritional Neuroscience. 25:286-298
Objectives: The impact of chronic exposure to environmental adversities on brain regions involved in cognition and mental health depends on whether it occurs during the perinatal period, childhood, adolescence or adulthood. The effects of these adver
Publikováno v:
Alzheimer's & Dementia. 16
Publikováno v:
Alzheimer's & Dementia. 15:P543-P544
Publikováno v:
Frontiers in Aging Neuroscience
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Aging Neuroscience, Vol 8 (2016)
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Aging Neuroscience, Vol 8 (2016)
Frontotemporal Dementia (FTD) and amyotrophic lateral sclerosis (ALS) are two neurodegenerative diseases associated to mislocalization and aggregation of TAR DNA-binding protein 43 (TDP-43). To investigate in depth the behavioral phenotype associated
The medial prefrontal cortex (mPFC) is known for its role in decision making and memory processing, including the participation in the formation of extinction memories. However, little is known regarding its contribution to aversive memory consolidat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16625305733d6d8d7fc76ca21d45fdc1
http://www.sciencedirect.com/science/article/pii/S1074742715001872
http://www.sciencedirect.com/science/article/pii/S1074742715001872
Autor:
Leo McCluskey, John Q. Trojanowski, Bruce L. Miller, Linda K. Kwong, Virginia M.-Y. Lee, Murray Grossman, Manuela Neumann, Christopher M. Clark, Kunihiro Uryu, Lauren Elman, Lionel M. Igaz, Yan Xu, Adam C. Truax
Publikováno v:
The American Journal of Pathology. 173:182-194
TAR DNA-binding protein (TDP-43) has been recently described as a major pathological protein in both frontotemporal dementia with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis. However, little is known about the relative ab
Autor:
Lionel M. Igaz, Margaret M. Wong, Matthew J. Winton, Virginia M.-Y. Lee, John Q. Trojanowski, Linda K. Kwong
Publikováno v:
Journal of Biological Chemistry. 283:13302-13309
TAR DNA-binding protein 43 (TDP-43) is the disease protein in frontotemporal lobar degeneration with ubiquitin-positive inclusions (FTLD-U) and amyotrophic lateral sclerosis (ALS). Although normal TDP-43 is a nuclear protein, pathological TDP-43 is r