TRIM28-dependent SUMOylation protects the adult ovary from activation of the testicular pathway

Autor: Moïra Rossitto, Stephanie Déjardin, Chris M. Rands, Stephanie Le Gras, Roberta Migale, Mahmoud-Reza Rafiee, Yasmine Neirijnck, Alain Pruvost, Anvi Laetitia Nguyen, Guillaume Bossis, Florence Cammas, Lionel Le Gallic, Dagmar Wilhelm, Robin Lovell-Badge, Brigitte Boizet-Bonhoure, Serge Nef, Francis Poulat

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

Gonadal fate in mammals is determined during embryogenesis and is actively maintained in adulthood. This study shows that E3-SUMO ligase activity of TRIM28 is required for ovarian identity maintenance and testicular-specific gene repression in mouse

Externí odkaz: https://doaj.org/article/ee83c64ad8d44323a3713a98d8b88a59

AMPK/HuR-Driven IL-20 Post-Transcriptional Regulation in Psoriatic Skin

Autor: Stéphanie Rialle, Lionel Le Gallic, Thierry Lavabre-Bertrand, Jean-Marie Joujoux, Matthieu Lacroix, Geneviève Garcin, Pierre-Emmanuel Stoebner, Clémence Genthon, Isabelle Guiraud, Laurent Meunier

Publikováno v: Journal of Investigative Dermatology
Journal of Investigative Dermatology, Nature Publishing Group, 2015, 135 (11), pp.2732-2741. ⟨10.1038/jid.2015.282⟩
Journal of Investigative Dermatology, 2015, 135 (11), pp.2732-2741. ⟨10.1038/jid.2015.282⟩

International audience; IL-20 is involved in the development of skin psoriasis. The molecular mechanisms underlying IL-20 overexpression in psoriatic epidermis remain to be elucidated. We showed that IL-20 was primarily upregulated in psoriatic skin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbc6a484572c97db2049a5b8f6fbbf04
https://hal.archives-ouvertes.fr/hal-01913752

ERF Nuclear Shuttling, a Continuous Monitor of Erk Activity That Links It to Cell Cycle Progression

Autor: George Mavrothalassitis, Lionel Le Gallic, Philip Cohen, Laura Virgilio, Benoît Biteau

Publikováno v: Molecular and Cellular Biology. 24:1206-1218

The ets domain transcriptional repressor ERF is an effector of the receptor tyrosine kinase/Ras/Erk pathway, which, it has been suggested, is regulated by subcellular localization as a result of Erk-dependent phosphorylation and is capable of suppres

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46e58bf78a3f3d1924fa0f26888092a8
https://doi.org/10.1128/mcb.24.3.1206-1218.2004

Decreased expression of thymidine phosphorylase/platelet-derived endothelial cell growth factor in basal cell carcinomas

Autor: Lionel Le Gallic, Thierry Lavabre-Bertrand, Laurent Meunier, Benjamin Lallemant, P.E. Stoebner, Catherine Gaspard, Jean Martinez, Christophe Delfour, Nathalie Boulle, M. Marque, Marie Laurence Berthe

Publikováno v: Experimental dermatology. 17(11)

Thymidine phosphorylase (TP)/platelet-derived endothelial cell growth factor is associated with tumor angiogenesis. We evaluated the TP mRNA and protein expression in basal cell carcinomas (BCC) and in various skin tumors including numerous BCC histo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8446897109d66414114bf655d109004f
https://pubmed.ncbi.nlm.nih.gov/18341568

Regulation of ERK1/2 activity by ghrelin-activated growth hormone secretagogue receptor 1A involves a PLC/PKCvarepsilon pathway

Autor: Delphine, Mousseaux, Lionel, Le Gallic, Joanne, Ryan, Catherine, Oiry, Didier, Gagne, Jean-Alain, Fehrentz, Jean-Claude, Galleyrand, Jean, Martinez

Publikováno v: British journal of pharmacology. 148(3)

1. The growth hormone secretagogue receptor 1a (GHSR-1a) is a G-protein coupled receptor, involved in the biological actions of ghrelin by triggering inositol phosphates and calcium intracellular second messengers. It has also been reported that ghre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7ad524b30b70c61a0baaed0befc21e29
https://pubmed.ncbi.nlm.nih.gov/16582936