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pro vyhledávání: '"Lionel Gellon"'
Autor:
Lionel Gellon, David F Razidlo, Olive Gleeson, Lauren Verra, Danae Schulz, Robert S Lahue, Catherine H Freudenreich
Publikováno v:
PLoS Genetics, Vol 7, Iss 2, p e1001298 (2011)
Expansion of DNA trinucleotide repeats causes at least 15 hereditary neurological diseases, and these repeats also undergo contraction and fragility. Current models to explain this genetic instability invoke erroneous DNA repair or aberrant replicati
Externí odkaz:
https://doaj.org/article/df62359b7a2d48c093fd41e76a685e52
Autor:
Sergei M. Mirkin, Simran Kaushal, Jorge Cebrian, Catherine H. Freudenreich, Mayurika Lahiri, Lionel Gellon
Publikováno v:
Nucleic Acids Research
Fork stabilization at DNA impediments is key to maintaining replication fork integrity and preventing chromosome breaks. Mrc1 and Tof1 are two known stabilizers that travel with the replication fork. In addition to a structural role, Mrc1 has a DNA d
Publikováno v:
DNA Repair. 7:187-198
In Saccharomyces cerevisiae, the base excision DNA repair (BER) pathway has been thought to involve only a multinucleotide (long-patch) mechanism (LP-BER), in contrast to most known cases that include a major single-nucleotide pathway (SN-BER). The k
Publikováno v:
Journal of Biological Chemistry. 277:29963-29972
Ntg2p is a DNAN-glycosylase/apurinic or apyrimidinic lyase involved in base excision repair of oxidatively damaged DNA inSaccharomyces cerevisiae. Using a yeast two-hybrid screen and a GST in vitro transcription and translation assay, the mismatch re
Publikováno v:
Free Radical Biology and Medicine. 32:1244-1253
8-Oxo-7,8-dihydroguanine (8-oxoG) is produced abundantly in DNA exposed to free radicals and reactive oxygen species. The biological relevance of 8-oxoG has been unveiled by the study of two mutator genes in Escherichia coli, fpg, and mutY. Both gene
Autor:
Danae Schulz, Robert S. Lahue, Catherine H. Freudenreich, Lionel Gellon, Lauren Verra, David F. Razidlo, Olive Gleeson
Publikováno v:
PLoS Genetics, Vol 7, Iss 2, p e1001298 (2011)
PLoS Genetics
PLoS Genetics
Expansion of DNA trinucleotide repeats causes at least 15 hereditary neurological diseases, and these repeats also undergo contraction and fragility. Current models to explain this genetic instability invoke erroneous DNA repair or aberrant replicati
Trinucleotide repeats can form secondary structures, whose inappropriate repair or replication can lead to repeat expansions. There are multiple loci within the human genome where expansion of trinucleotide repeats leads to disease. Although it is kn
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b45656ffde6e1fa8f6f5ccc6e67879d
https://europepmc.org/articles/PMC2815931/
https://europepmc.org/articles/PMC2815931/
Publikováno v:
DNA repair. 6(11)
Replication forks stall at DNA lesions or as a result of an unfavorable replicative environment. These fork stalling events have been associated with recombination and gross chromosomal rearrangements. Recombination and fork bypass pathways are the m
Publikováno v:
Free radical biologymedicine. 32(12)
8-Oxo-7,8-dihydroguanine (8-oxoG) is produced abundantly in DNA exposed to free radicals and reactive oxygen species. The biological relevance of 8-oxoG has been unveiled by the study of two mutator genes in Escherichia coli, fpg, and mutY. Both gene
Publikováno v:
The Journal of biological chemistry. 277(33)
Ntg2p is a DNA N-glycosylase/apurinic or apyrimidinic lyase involved in base excision repair of oxidatively damaged DNA in Saccharomyces cerevisiae. Using a yeast two-hybrid screen and a GST in vitro transcription and translation assay, the mismatch