Preventive effects of a nutraceutical mixture of berberine, citrus and apple extracts on metabolic disturbances in Zucker fatty rats.

Autor: Mohamed Siliman Misha, Sandrine Destrumelle, Dylan Le Jan, Nahla M Mansour, Lionel Fizanne, Khadija Ouguerram, Jean-Claude Desfontis, Mohamed-Yassine Mallem

Publikováno v: PLoS ONE, Vol 19, Iss 7, p e0306783 (2024)

BackgroundThe prevention of obesity represents a major health and socio-economic challenge. Nutraceuticals are regularly highlighted for their beneficial effects in preventing the metabolic disturbances associated with obesity. However, few studies h

Externí odkaz: https://doaj.org/article/b2f3eab1d0aa477abff8b04064f10bde

Lipidomic analysis of adipose-derived extracellular vesicles reveals specific EV lipid sorting informative of the obesity metabolic state

Autor: Alexia Blandin, Isabelle Dugail, Grégory Hilairet, Maharajah Ponnaiah, Valentine Ghesquière, Josy Froger, Simon Ducheix, Lionel Fizanne, Jérôme Boursier, Bertrand Cariou, Marie Lhomme, Soazig Le Lay

Publikováno v: Cell Reports, Vol 42, Iss 3, Pp 112169- (2023)

Summary: Adipose extracellular vesicles (AdEVs) transport lipids that could participate in the development of obesity-related metabolic dysfunctions. This study aims to define mouse AdEV lipid signature by a targeted LC-MS/MS approach in either healt

Externí odkaz: https://doaj.org/article/b12b42aeaf9045f1b97d9a702fa20880

GNS561 acts as a potent anti-fibrotic and pro-fibrolytic agent in liver fibrosis through TGF-β1 inhibition

Autor: Eloïne Bestion, Zuzana Macek Jilkova, Jean-Louis Mège, Marie Novello, Keerthi Kurma, Seyedeh Tayebeh Ahmad Pour, Gilles Lalmanach, Lise Vanderlynden, Lionel Fizanne, Firas Bassissi, Madani Rachid, Jennifer Tracz, Jérôme Boursier, Jérôme Courcambeck, Cindy Serdjebi, Christelle Ansaldi, Thomas Decaens, Philippe Halfon, Sonia Brun

Publikováno v: Therapeutic Advances in Chronic Disease, Vol 11 (2020)

Background: Hepatic fibrosis is the result of chronic liver injury that can progress to cirrhosis and lead to liver failure. Nevertheless, there are no anti-fibrotic drugs licensed for human use. Here, we investigated the anti-fibrotic activity of GN

Externí odkaz: https://doaj.org/article/1f2c4f5fc156452bb5c3b4df23efc116

Apple Supplementation Improves Hemodynamic Parameter and Attenuates Atherosclerosis in High-Fat Diet-Fed Apolipoprotein E-Knockout Mice

Autor: Raffaella Soleti, Charlotte Trenteseaux, Lionel Fizanne, Marine Coué, Gregory Hilairet, Fatima Kasbi-Chadli, Patricia Mallegol, Julien Chaigneau, Jerome Boursier, Michel Krempf, Mathilde Orsel, Khadija Ouguerram, Ramaroson Andriantsitohaina

Publikováno v: Biomedicines, Vol 8, Iss 11, p 495 (2020)

Epidemiological studies describe the association between apple consumption and improved cardiovascular and metabolic dysfunction. Our recent multiparametric screening on cellular model studies has shown that apples exhibit vascular tropism including

Externí odkaz: https://doaj.org/article/1250a7738a4743a487d4a6455f648a2e

Carrot Supplementation Improves Blood Pressure and Reduces Aortic Root Lesions in an Atherosclerosis-Prone Genetic Mouse Model

Autor: Patricia Mallegol, Julien Chaigneau, Khadija Ouguerram, Ramaroson Andriantsitohaina, Michel Krempf, Jérôme Boursier, Raffaella Soleti, Fatima Kasbi-Chadli, Emmanuel Geoffriau, Lionel Fizanne, Marine Coué, Charlotte Trenteseaux, Grégory Hilairet

Publikováno v: Nutrients
Nutrients, 2021, 13 (4), pp.1-14. ⟨10.3390/nu13041181⟩
Nutrients, MDPI, 2021, 13 (4), pp.1181. ⟨10.3390/nu13041181⟩
Nutrients, MDPI, 2021, 13 (4), pp.1-14. ⟨10.3390/nu13041181⟩
Volume 13
Issue 4
Nutrients, Vol 13, Iss 1181, p 1181 (2021)

International audience; Epidemiological studies have shown that carrot consumption may be associated with a lower risk of developing several metabolic dysfunctions. Our group previously determined that the Bolero (Bo) carrot variety exhibited vascula

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e43ab35dd73680249118a76d5a4003
https://univ-angers.hal.science/hal-03284268