Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lionel Durant"'
Autor:
Cédric Raymond, François Moreau, Laure Prouvensier, Jean-Marie Genevard, Yannick Bonvin, Lionel Durant, Laëtitia Peltier, Armelle Walton, Coralie Soulama-Mouze, Stéphanie Floquet, Elodie Drocourt, Vincent Gerusz, Mayalen Oxoby, Sonia Escaich, Géraldine LeFralliec, Vanessa Sam-Sambo, Vanida Vongsouthi, Nicolas Desroy, Marc Saccomani, Chrystelle Oliveira, Sophia Briet, Alexis Denis, Fabien Faivre
Publikováno v:
Journal of Medicinal Chemistry. 55:9914-9928
In this paper, we present some elements of our optimization program to decouple triclosan's specific FabI effect from its nonspecific cytotoxic component. The implementation of this strategy delivered highly specific, potent, and nonbiocidal new FabI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8cec45f475491713180acfabe1b6f5a
https://doi.org/10.1021/jm301113w
https://doi.org/10.1021/jm301113w
Autor:
Lionel Durant, Sonia Escaich, Jean-Marie Genevard, Alexis Denis, François Moreau, Mayalen Oxoby, Vincent Gerusz, Vanida Vongsouthi
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:3486-3490
Haspin is a serine/threonine kinase required for completion of normal mitosis that is highly expressed during cell proliferation, including in a number of neoplasms. Consequently, it has emerged as a potential therapeutic target in oncology. A high t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fb23333c6fec52e747e2cf542177e92
https://doi.org/10.1016/j.bmcl.2010.05.004
https://doi.org/10.1016/j.bmcl.2010.05.004
Autor:
Alexis Denis, Nicolas Desroy, Sonia Escaich, Lionel Durant, Vincent Gerusz, Vanida Vongsouthi, Géraldine Le Fralliec, François Moreau, Stéphanie Floquet, Sophia Briet
Publikováno v:
Bioorganic & Medicinal Chemistry. 17:1276-1289
Gram-negative bacteria lacking heptoses in their lipopolysaccharide (LPS) display attenuated virulence and increased sensitivity to human serum and to some antibiotics. Thus inhibition of bacterial heptose synthesis represents an attractive target fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c5c8e0751613ede387a95852db1e194a
https://doi.org/10.1016/j.bmc.2008.12.021
https://doi.org/10.1016/j.bmc.2008.12.021
Autor:
U Kaerst, N Simoes, Philippe Glaser, Matthias Rose, Pierre Dehoux, José A. Vázquez-Boland, Alain Charbit, F García-del Portillo, B de Pablos, Patrick Berche, Werner Goebel, D Jackson, K-D Entian, Lionel Durant, Hafida Fsihi, Hafed Nedjari, H Bloecker, Nuria Gomez-Lopez, R Purcell, Encarnación Madueño, A. Tierrez, A de Daruvar, Susana Novella, Carmen Buchrieser, Fernando Baquero, Jörg Hauf, J Mata Vicente, Gustavo Domínguez-Bernal, T Schlueter, P Brandt, Lionel Frangeul, Michael Kuhn, A Maitournam, Jürgen Kreft, L-M Jones, G Nordsiek, B Remmel, Laurent Gautier, Pascale Cossart, F. Kunst, Eric Duchaud, José-Claudio Perez-Diaz, E Ng, Alexandra Amend, Elisabeth Couvé, Torsten Hain, Farid Chetouani, Hamut Voss, Olivier Dussurget, Christophe Rusniok, Jürgen Wehland, P. Garrido, G Kurapkat, Eugen Domann, Trinad Chakraborty
Publikováno v:
Science
Science, American Association for the Advancement of Science, 2001, 294 (5543), pp.849-852. ⟨10.1126/science.1063447⟩
Science, 2001, 294 (5543), pp.849-852. ⟨10.1126/science.1063447⟩
Science, American Association for the Advancement of Science, 2001, 294 (5543), pp.849-852. ⟨10.1126/science.1063447⟩
Science, 2001, 294 (5543), pp.849-852. ⟨10.1126/science.1063447⟩
Listeria monocytogenes is a food-borne pathogen with a high mortality rate that has also emerged as a paradigm for intracellular parasitism. We present and compare the genome sequences of L. monocytogenes (2,944,528 base pairs) and a nonpathogenic sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33e2ec71650f5e0d5b623d37cbd75e53
https://doi.org/10.1126/science.1063447
https://doi.org/10.1126/science.1063447
Autor:
Nicolas Desroy, Vanida Vongsouthi, Stéphanie Floquet, Dmytro Atamanyuk, Vincent Gerusz, Géraldine LeFralliec, François Moreau, Theodore B. Verhey, Ting-Wai Lee, Lionel Durant, Yannick Bonvin, Sophia Briet, Alexis Denis, Mayalen Oxoby, Fabien Faivre, Elodie Drocourt, Sonia Escaich, Chrystelle Oliveira, Murray S. Junop
Publikováno v:
Journal of medicinal chemistry. 56(4)
We report here the optimization of an HldE kinase inhibitor to low nanomolar potency, which resulted in the identification of the first reported compounds active on selected E. coli strains. One of the most interesting candidates, compound 86, was sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2890016c6843ce1a2e7be486ac05f257
https://pubmed.ncbi.nlm.nih.gov/23409840
https://pubmed.ncbi.nlm.nih.gov/23409840
Autor:
Sonia Escaich, Lionel Durant, Xavier Nassif, Arnaud Metais, Coralie Soulama-Mouze, Jean-Marie Genevard
Publikováno v:
Infection and immunity. 75(4)
Extraintestinal pathogenic Escherichia coli (ExPEC) strains cause a large spectrum of infections. The majority of ExPEC strains are closely related to the B2 or the D phylogenetic group. The aim of our study was to develop a protein-based vaccine aga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf03106e67b17da7f67d6660ef2709a4
https://pubmed.ncbi.nlm.nih.gov/17145948
https://pubmed.ncbi.nlm.nih.gov/17145948
Publikováno v:
Journal of Bacteriology
Journal of Bacteriology, American Society for Microbiology, 2000, 182 (20), pp.5931-5934. ⟨10.1128/jb.182.20.5931-5934.2000⟩
Journal of Bacteriology, 2000, 182 (20), pp.5931-5934. ⟨10.1128/jb.182.20.5931-5934.2000⟩
Journal of Bacteriology, American Society for Microbiology, 2000, 182 (20), pp.5931-5934. ⟨10.1128/jb.182.20.5931-5934.2000⟩
Journal of Bacteriology, 2000, 182 (20), pp.5931-5934. ⟨10.1128/jb.182.20.5931-5934.2000⟩
We identified in Listeria monocytogenes a gene encoding a protein homologous to MecA, a regulatory protein acting with ClpC and ComK in the competence pathway of Bacillus subtilis . In L. monocytogenes , MecA is involved, along with ClpC and ClpP, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad626c304258bfa6bd1b4401d684d6b7
https://pubmed.ncbi.nlm.nih.gov/11004200
https://pubmed.ncbi.nlm.nih.gov/11004200
Akademický článek
Tento výsledek nelze pro nepřihlášené uživatele zobrazit.
K zobrazení výsledku je třeba se přihlásit.
K zobrazení výsledku je třeba se přihlásit.