Kinetic features of L,D-transpeptidase inactivation critical for β-lactam antibacterial activity.

Autor: Sébastien Triboulet, Vincent Dubée, Lauriane Lecoq, Catherine Bougault, Jean-Luc Mainardi, Louis B Rice, Mélanie Ethève-Quelquejeu, Laurent Gutmann, Arul Marie, Lionel Dubost, Jean-Emmanuel Hugonnet, Jean-Pierre Simorre, Michel Arthur

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e67831 (2013)

Active-site serine D,D-transpeptidases belonging to the penicillin-binding protein family (PBPs) have been considered for a long time as essential for peptidoglycan cross-linking in all bacteria. However, bypass of the PBPs by an L,D-transpeptidase (

Externí odkaz: https://doaj.org/article/aa2ddf5aa04449c4981354f023d448f0

In Vitro Cross-Linking of Mycobacterium tuberculosis Peptidoglycan by l , d -Transpeptidases and Inactivation of These Enzymes by Carbapenems

Autor: Mathilde Cordillot, Lionel Dubost, Jean-Luc Mainardi, Michel Arthur, Vincent Dubée, Sébastien Triboulet, Jean-Emmanuel Hugonnet, Arul Marie

Publikováno v: Antimicrobial Agents and Chemotherapy. 57:5940-5945

The Mycobacterium tuberculosis peptidoglycan is cross-linked mainly by l , d -transpeptidases (LDTs), which are efficiently inactivated by a single β-lactam class, the carbapenems. Development of carbapenems for tuberculosis treatment has recently r

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0c36d0d170be997072f99d630cebaa3
https://doi.org/10.1128/aac.01663-13

Inactivation of Mycobacterium tuberculosis L,D-Transpeptidase Ldt(Mt1) by Carbapenems and Cephalosporins

Autor: Mélanie Etheve-Quelquejeu, Jean-Emmanuel Hugonnet, Arul Marie, Michel Arthur, Vincent Dubée, Sébastien Triboulet, Laurent Gutmann, Jean-Luc Mainardi, Lionel Dubost

Publikováno v: Antimicrobial Agents and Chemotherapy; Vol 56

The structure of Mycobacterium tuberculosis peptidoglycan is atypical since it contains a majority of 3→3 cross-links synthesized by l , d -transpeptidases that replace 4→3 cross-links formed by the d , d -transpeptidase activity of classical pen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e15e32bdf9200c3a38bd3eb10c57816

Synthesis of Naturally Occurring Cyclohexene Rings Using Stereodirected Intramolecular Diels-Alder Reactions Through Asymmetric 1,3-Dioxane Tethering

Autor: Lionel Dubost, Bastien Nay, Hajer Abdelkafi, Alexandre Deville, Angèle Chiaroni, Laurent Evanno

Publikováno v: European Journal of Organic Chemistry
European Journal of Organic Chemistry, Wiley-VCH Verlag, 2011, pp.2789-2800. ⟨10.1002/ejoc.201001678⟩

The utility of the readily available asymmetric 1,3-dioxane template in intramolecular Diels-Alder reactions is reported. The 1,3,9-decatrienoates substrates gave predominantly the endo-boat products, with minor amounts of the exo-boat isomer. Variou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4568b827236b2326506d8d565bcbf6f
https://doi.org/10.1002/ejoc.201001678

Total Synthesis of Tyrosine-Derived Tetramic Acid Pigments from a Slime Mould

Autor: Lionel Dubost, Christine Bailly, Bastien Nay, Nassima Riache, Alexandre Deville

Publikováno v: European Journal of Organic Chemistry. 2010:5402-5408

A method for the total synthesis of naturally occurring 3-en-oyltetramic acids derived from L-tyrosine is described, allowing for three chemical transformations to occur in one pot by using a multicomponent mixture. The sequence involves (1) a base-p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8911985714fafb2514196fd07bb2338d
https://doi.org/10.1002/ejoc.201000597