Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Lionel C. Clement"'
Autor:
Maria Del Nogal Avila, Ranjan Das, Joubert Kharlyngdoh, Eduardo Molina-Jijon, Hector Donoro Blazquez, Stéphanie Gambut, Michael Crowley, David K. Crossman, Rasheed A. Gbadegesin, Sunveer S. Chugh, Sunjeet S. Chugh, Carmen Avila-Casado, Camille Macé, Lionel C. Clement, Sumant S. Chugh
Publikováno v:
JCI Insight, Vol 8, Iss 10 (2023)
Viral illnesses like SARS-CoV-2 have pathologic effects on nonrespiratory organs in the absence of direct viral infection. We injected mice with cocktails of rodent equivalents of human cytokine storms resulting from SARS-CoV-2/COVID-19 or rhinovirus
Externí odkaz:
https://doaj.org/article/dcf748d651fa43ff93ecd46471a7f1db
Autor:
Sumant Singh Chugh, Camille eMace, Lionel C Clement, Maria eDel Nogal Avila, Caroline eMarshall
Publikováno v:
Frontiers in Pharmacology, Vol 5 (2014)
Current drugs used to treat proteinuric disorders of the kidney have been borrowed from other branches of medicine, and are only partially effective. The discovery of a central, mechanistic role played by two different forms of the secreted glycoprot
Externí odkaz:
https://doaj.org/article/92231887e52a494783485904c53161d8
Autor:
Stefan Nagel, Rasheed A Gbadagesin, Carmen Avila Casado, David K. Crossman, Hector Donoro Blazquez, Eduardo Molina Jijon, Sumant S. Chugh, Maria Del Nogal Avila, Michael J. Crowley, Joubert Banjop Kharlyngdoh, Ranjan Das, Lionel C. Clement, Stéphanie Gambut, Camille Macé
Publikováno v:
Nephrology Dialysis Transplantation. 35
Background and Aims ZHX2 transcriptional factor is normally found in podocyte membrane forming complexes with ZHX1 and APA or ZHX3 and Ephrin B1. Altered ZHX2 expression disrupts these interactions and is related with the worsening of different prima
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::edb9f6b9ba940017ad26ac639fd96595
https://doi.org/10.1093/ndt/gfaa144.p0046
https://doi.org/10.1093/ndt/gfaa144.p0046
Publikováno v:
Kidney Int
The proprotein PCSK9 functions as a chaperone for the epithelial sodium channel in the cortical collecting duct (CCD), is highly expressed in the liver, and plays a significant role in the pathogenesis of hypercholesterolemia. Lower levels of PCSK9 e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e166cf6a1d037da162a430cd35f6b629
https://pubmed.ncbi.nlm.nih.gov/33276863
https://pubmed.ncbi.nlm.nih.gov/33276863
Autor:
Camille Macé, Lionel C. Clement
Publikováno v:
médecine/sciences. 32:606-611
Current therapies used in minimal change disease (MCD) were originally designed to cure other diseases. They are only partially efficient, and present inconvenient side effects. Therefore, understanding the molecular mechanisms implicated in the path
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ecc30d0071a23bec7990f738ad2b953
https://doi.org/10.1051/medsci/20163206024
https://doi.org/10.1051/medsci/20163206024
Autor:
Caroline B. Marshall, Camille Macé, Sumant S. Chugh, Maria Del Nogal Avila, Lionel C. Clement
Publikováno v:
Translational Research. 165:499-504
The development of new and specific treatment options for kidney disease in general and glomerular diseases in specific has lagged behind other fields like heart disease and cancer. As a result, nephrologists have had to test and adapt therapeutics d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc0b5f27adec04ff138f3801d394c988
https://doi.org/10.1016/j.trsl.2014.06.004
https://doi.org/10.1016/j.trsl.2014.06.004
Autor:
Jaap A. Joles, Lionel C. Clement, Camille Macé, Sumant S. Chugh, Sander Kersten, Carmen Avila-Casado
Publikováno v:
Nature Medicine 20 (2014) 1
Nature Medicine, 20(1), 37-46
Nature Medicine, 20(1), 37-46
The molecular link between proteinuria and hyperlipidemia in nephrotic syndrome is not known. We show in the present study that plasma angiopoietin-like 4 (Angptl4) links proteinuria with hypertriglyceridemia through two negative feedback loops. In p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a26e5d15ab95a99b5cdbd431fcab38c2
https://doi.org/10.1038/nm.3396
https://doi.org/10.1038/nm.3396
Autor:
Caroline B. Marshall, Camille Macé, Hector Donoro-Blazquez, María del Nogal-Avila, Lionel C. Clement, Sumant S. Chugh, Manish K. Saha
Improved understanding of glomerular disease mechanisms over the past decade has led to the emergence of new and targeted therapeutic strategies for chronic kidney disease (CKD). Most promising among these are the administration of recombinant mutate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e35718092ba9eea3cd88579e52bfb98
https://europepmc.org/articles/PMC4967169/
https://europepmc.org/articles/PMC4967169/
Publikováno v:
American Journal of Kidney Diseases. 59:284-292
The pathogenesis of minimal change disease (MCD), considered to be the simplest form of nephrotic syndrome, has been one of the major unsolved mysteries in kidney disease. In this review, recent landmark studies that have led to the unraveling of MCD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed2423f9f76686c2fc7ff8057e4c3e08
https://doi.org/10.1053/j.ajkd.2011.07.024
https://doi.org/10.1053/j.ajkd.2011.07.024
Autor:
Elizabeth Soria, Lionel C. Clement, Winston W Bakker, Sander Kersten, Camille Macé, Carmen Avila-Casado, Sumant S. Chugh
Publikováno v:
Nature medicine
Nature Medicine, 17(1), 117-122
Nature Medicine, 17(1), 117-U294. Nature Publishing Group
Nature Medicine 17 (2011) 1
Nature Medicine, 17(1), 117-122
Nature Medicine, 17(1), 117-U294. Nature Publishing Group
Nature Medicine 17 (2011) 1
The main manifestations of nephrotic syndrome include proteinuria, hypoalbuminemia, edema, hyperlipidemia and lipiduria. Common causes of nephrotic syndrome are diabetic nephropathy, minimal change disease (MCD), focal and segmental glomerulosclerosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a9520138783914e86b7871750a10c0
https://doi.org/10.1038/nm.2261
https://doi.org/10.1038/nm.2261