Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Lionel Bert"'
Autor:
Jean-Marie Delbos, Esther Steidl, Tuulia Huhtala, Aurore Sors, Jean-Michel Arrang, Bruno Buisson, Patrick Casara, Outi Kontkanen, Lionel Bert, Valérie Audinot, Pierre Lestage, Olivier Nosjean, Anne-Marie Chollet, Fany Panayi, Dominique Favale
Publikováno v:
European Journal of Pharmacology. 803:11-23
Histaminergic H3 inverse agonists, by stimulating central histamine release, represent attractive drug candidates to treat cognitive disorders. The present studies aimed to describe the mechanistic profile of S 38093 a novel H3 receptors inverse agon
Autor:
Fany Panayi, Pierre Lestage, Luigi Pira, Valerie Bertaina-Anglade, Rodolphe Billiras, Laurence Danober, Karine Albinet, Brigitte Martin, Jean-Yves Thomas, Isabelle Carrié, Gaelle Rollin-Jego, Aurore Sors, Lionel Bert, Nathalie Rogez
Publikováno v:
European journal of pharmacology. 803
S 38093, a novel histamine H3 receptor inverse agonist, was tested in a series of neurochemical and behavioral paradigms designed to evaluate its procognitive and arousal properties. In intracerebral microdialysis studies performed in rats, S 38093 d
Autor:
François Vallée, Mati Lopez-Grancha, Dominique Françon, Tatiana Tolstykh, Scott Brittain, Heike Arlt, Franck Augé, Michel Didier, Thibaud Leroy, Lionel Bert, Guy Griebel, Sandra Beeské, Fangxian Sun, Bailin Zhang, Nicolas Redon, Patrick Avenet, Vincent Mikol, Nadine Michot, Véronique Menet, Jacques Houtmann, Timothy He, Johanna Escoubet, Alexey Rak, Agnès Jacquet, Dmitri Wiederschain, Pascal George, Thomas Bertrand, Luc Even, Olivier Bergis, Philippe Pichat, Qunyan Yu
Publikováno v:
Scientific Reports
'Scientific Reports ', vol: 5, pages: 7642-1-7642-16 (2015)
'Scientific Reports ', vol: 5, pages: 7642-1-7642-16 (2015)
Monoacylglycerol lipase (MAGL) represents a primary degradation enzyme of the endogenous cannabinoid (eCB), 2-arachidonoyglycerol (2-AG). This study reports a potent covalent MAGL inhibitor, SAR127303. The compound behaves as a selective and competit
Publikováno v:
Journal of Neuroscience Research. 71:445-454
To determine whether glutamate (Glu) and aspartate (Asp) undergo a similar regulation of their extracellular levels, Glu and Asp were simultaneously monitored in the striatum of anesthetized rats after local N-methyl-D-aspartate (NMDA) receptor stimu
Autor:
Frédéric Robert, Joyce Colussi-Mas, Luc Denoroy, Marie-Françoise Suaud-Chagny, Bernard Renaud, Lionel Bert, Sandrine Parrot, Laura Lambás-Señas, Jean-Pierre Bouilloux, Laurence Mouly-Badina, Valérie Sauvinet
Publikováno v:
Cellular and Molecular Neurobiology. 23:793-804
1. Although microdialysis is a widely used approach for in vivo monitoring extracellular neurotransmitter concentrations, it has been previously limited in many cases by its poor temporal resolution. It is clear that when 10–30-min sampling is perf
Autor:
Sandrine Parrot, Lionel Bert, C. Desvignes, Marie-Françoise Suaud-Chagny, Luc Denoroy, Bernard Renaud, F. Robert
Publikováno v:
Neuropharmacology. 43:825-835
In vivo microdialysis was used to investigate the interactions between dopamine (DA), glutamate (Glu) and aspartate (Asp) in anaesthetised-rat striatum. The combination of brain microdialysis and capillary electrophoresis with laser-induced fluoresce
Publikováno v:
Comptes Rendus Biologies. 325:495-504
We have investigated the effects of various insults on extracellular glutamate and phosphoethanolamine levels as well as electrical activity alterations in the early period following these insults in organotypic hippocampal slice cultures. Cultures p
Autor:
D. Rodier, Régis Steinberg, Gérard Le-Fur, Lionel Bert, Isabelle Bougault, Philippe Soubrie, Nathalie Allouard
Publikováno v:
Synapse. 43:62-69
The present experiments investigated the role of neurokinin-1 (NK(1)) and neurokinin-3 (NK(3)) receptors on the activity of the locus coeruleus (LC)-noradrenergic system by using a dual probe microdialysis technique in anesthetized guinea pigs. The l
Publikováno v:
Electrophoresis. 19:2841-2847
Microdialysis sampling combined with capillary electrophoresis is emerging as a new approach in drug studies. It allows the continuous monitoring, in vivo or in vitro, of changes in free endogenous compounds as well as in drug substances, following t
Publikováno v:
Journal of Neuroscience Methods. 74:65-76
These experiments combined extracellular electrophysiological multirecordings from hippocampal organotypic slice cultures with application of drugs to and sampling of extracellular fluid from a restricted region of the slice using a microdialysis pro