Zobrazeno 1 - 10
of 41
pro vyhledávání: '"Lionel A. Tintignac"'
Autor:
Marco S. Kaiser, Giulia Milan, Daniel J. Ham, Shuo Lin, Filippo Oliveri, Kathrin Chojnowska, Lionel A. Tintignac, Nitish Mittal, Christian E. Zimmerli, David J. Glass, Mihaela Zavolan, Markus A. Rüegg
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-18 (2022)
Exploring the relationship between mTORC1 and the ubiquitin-proteasome system, light is shed on the paradox between mTORC1-mediated muscle hypertrophy induced by PKB/Akt and the muscle atrophy induced by mTORC1 alone.
Externí odkaz:
https://doaj.org/article/f20a08691add485199dd53a06c8fd523
Autor:
Daniel J. Ham, Anastasiya Börsch, Kathrin Chojnowska, Shuo Lin, Aurel B. Leuchtman, Alexander S. Ham, Marco Thürkauf, Julien Delezie, Regula Furrer, Dominik Burri, Michael Sinnreich, Christoph Handschin, Lionel A. Tintignac, Mihaela Zavolan, Nitish Mittal, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
The anti-aging intervention calorie restriction (CR) is thought to act via the nutrient-sensing multiprotein complex mTORC1. Here the authors show that the mTORC1-inhibitor rapamycin and CR use largely distinct mechanisms to slow mouse muscle aging.
Externí odkaz:
https://doaj.org/article/444da6d136f045099a95445e8d650a04
Autor:
Anastasiya Börsch, Daniel J. Ham, Nitish Mittal, Lionel A. Tintignac, Eugenia Migliavacca, Jérôme N. Feige, Markus A. Rüegg, Mihaela Zavolan
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
Anastasiya Börsch, Daniel Ham, and colleagues generated a time series of phenotypic measurements and RNA-Seq data from mouse skeletal muscle and comparatively analyzed these along comparable rat and human data, to assess the relevance of rodent mode
Externí odkaz:
https://doaj.org/article/2d627932b677454c8644b2aba9b64e4a
Autor:
Daniel J. Ham, Anastasiya Börsch, Shuo Lin, Marco Thürkauf, Martin Weihrauch, Judith R. Reinhard, Julien Delezie, Fabienne Battilana, Xueyong Wang, Marco S. Kaiser, Maitea Guridi, Michael Sinnreich, Mark M. Rich, Nitish Mittal, Lionel A. Tintignac, Christoph Handschin, Mihaela Zavolan, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-21 (2020)
mTORC1 expression is increased during ageing of muscle, and on the other hand, its activation promotes muscle hypertrophy. Here, the authors assess whether mTORC1 has positive or negative effects on ageing, and show that its long-term inhibition pres
Externí odkaz:
https://doaj.org/article/05a591c692df4b149c92e816d5905072
Autor:
Nathalie Bouquier, Enora Moutin, Lionel A. Tintignac, Amandine Reverbel, Elodie Jublanc, Michael Sinnreich, Yan Chastagnier, Julien Averous, Pierre Fafournoux, Chiara Verpelli, Tobias Boeckers, Gilles Carnac, Julie Perroy, Vincent Ollendorff
Publikováno v:
BMC Biology, Vol 18, Iss 1, Pp 1-17 (2020)
Abstract Background mTOR signaling is an essential nutrient and energetic sensing pathway. Here we describe AIMTOR, a sensitive genetically encoded BRET (Bioluminescent Resonance Energy Transfer) biosensor to study mTOR activity in living cells. Resu
Externí odkaz:
https://doaj.org/article/de858ec3955d4d94a438dc5be235f72e
Autor:
Alexander S. Ham, Kathrin Chojnowska, Lionel A. Tintignac, Shuo Lin, Alexander Schmidt, Daniel J. Ham, Michael Sinnreich, Markus A. Rüegg
Publikováno v:
Journal of Cachexia, Sarcopenia and Muscle, Vol 11, Iss 1, Pp 259-273 (2020)
Abstract Background The balance between protein synthesis and degradation (proteostasis) is a determining factor for muscle size and function. Signalling via the mammalian target of rapamycin complex 1 (mTORC1) regulates proteostasis in skeletal musc
Externí odkaz:
https://doaj.org/article/463dbe3786a54576826b6dcaf9675034
Autor:
Daniel J. Ham, Anastasiya Börsch, Kathrin Chojnowska, Shuo Lin, Aurel B. Leuchtmann, Alexander S. Ham, Marco Thürkauf, Julien Delezie, Regula Furrer, Dominik Burri, Michael Sinnreich, Christoph Handschin, Lionel A. Tintignac, Mihaela Zavolan, Nitish Mittal, Markus A. Rüegg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-1 (2022)
Externí odkaz:
https://doaj.org/article/c879cf0cbe364394806d8ecf246c6dbb
Autor:
Christoph Handschin, Aurel B. Leuchtmann, Mihaela Zavolan, Julien Delezie, Anastasiya Börsch, Regula Furrer, Dominik Burri, Daniel J. Ham, Nitish Mittal, Lionel A. Tintignac, Thürkauf M, Shuo Lin, Michael Sinnreich, Alexander S. Ham, Markus A. Rüegg, Kathrin Chojnowska
As global life expectancy continues to climb, maintaining skeletal muscle function is increasingly essential to ensure a good life quality for aging populations. Calorie restriction (CR) is the most potent and reproducible intervention to extend heal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::45a6cb405efb16d53c344bb20a9ee96f
Autor:
Mihaela Zavolan, Christian E Zimmerli, Shuo Lin, Marco S. Kaiser, Nitish Mittal, Giulia Milan, Lionel A. Tintignac, Filippo Oliveri, Daniel J. Ham, David J. Glass, Markus A. Rüegg, Kathrin Chojnowska
Muscle size is controlled by the PI3K-PKB/Akt-mTORC1-FoxO pathway, which integrates signals from growth factors, energy and amino acids to activate protein synthesis and inhibit protein breakdown. While mTORC1 activity is necessary for PKB/Akt-induce
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75b5f83005dcabd2fb2ec1702488d651
Autor:
Anastasiya, Börsch, Daniel J, Ham, Nitish, Mittal, Lionel A, Tintignac, Eugenia, Migliavacca, Jérôme N, Feige, Markus A, Rüegg, Mihaela, Zavolan
Publikováno v:
Communications Biology
Sarcopenia, the age-related loss of skeletal muscle mass and function, affects 5–13% of individuals aged over 60 years. While rodents are widely-used model organisms, which aspects of sarcopenia are recapitulated in different animal models is unkno