Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Lionel A. Samayawardhena"'
Publikováno v:
The Journal of Immunology. 185:5993-6002
Mast cell activation via FcεRI involves activation of the Src family kinases (SFKs) Lyn, Fyn, and Hck that positively or, in the case of Lyn, negatively regulate cellular responses. Little is known of upstream activators of these SFKs in FcεRI-depe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::523a5b1f2fda3a1ea1ff3e3cce74f176
https://doi.org/10.4049/jimmunol.1001261
https://doi.org/10.4049/jimmunol.1001261
Publikováno v:
Cellular Signalling. 22:427-436
Activation of Kit receptor protein-tyrosine kinase (PTK) by its ligand Stem Cell Factor (SCF) is required for the development of mast cells, and for the regulation of mast cell proliferation, migration and modulation of inflammatory mediator release.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca0aa62f3e79e6a00d0e277d6d0d9e2
https://doi.org/10.1016/j.cellsig.2009.10.014
https://doi.org/10.1016/j.cellsig.2009.10.014
Autor:
Shirley C. Chen, Ranvikram S. Khanna, Lionel A. Samayawardhena, Darrell C. Bessette, Catherine J. Pallen
Publikováno v:
American Journal of Physiology-Cell Physiology. 297:C133-C139
Protein tyrosine phosphatase-alpha (PTPalpha) is a widely expressed receptor-type phosphatase that functions in multiple signaling systems. The actions of PTPalpha can be regulated by its phosphorylation on serine and tyrosine residues, although litt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7ce61de1383292d744bc8479b09243b
https://doi.org/10.1152/ajpcell.00110.2009
https://doi.org/10.1152/ajpcell.00110.2009
Publikováno v:
Blood. 109:3679-3686
Kit receptor and its ligand stem cell factor (SCF) are critical regulators of mast cell production, proliferation, degranulation, and chemotaxis. In this study, we investigated how Fyn kinase regulates chemotaxis of mast cells toward SCF. On β1-inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cd375847b770b6b4d025f9daa7c3598e
https://doi.org/10.1182/blood-2006-11-057315
https://doi.org/10.1182/blood-2006-11-057315
Publikováno v:
Cellular Signalling. 18:1447-1454
The c-Kit receptor protein–tyrosine kinase plays a critical role in the differentiation, growth and survival of mast cells. Binding of its ligand stem cell factor (SCF), induces c-Kit dimerization, autophosphorylation, and recruitment of signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26bf9f08dd92614e844c0eaf541c42e2
https://doi.org/10.1016/j.cellsig.2005.11.005
https://doi.org/10.1016/j.cellsig.2005.11.005
Publikováno v:
Journal of Emergency Nursing. 37:391-393
3% of rear impacts involving child occupants. In addition, other studies have reported child mortality rates of 30% for side-impact crashes and 17% for frontal-impact crashes. 3-9 Because of the large size of the head in relation to the rest of the b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4c45563433b277022e0077f2ce45502
https://doi.org/10.1016/j.jen.2011.03.012
https://doi.org/10.1016/j.jen.2011.03.012
Autor:
Lionel A. Samayawardhena, Giulia Scime-Beltrano, Ediriweera B. R. Desapriya, Sayed Subzwari, Ian Pike
Publikováno v:
Journal of cataract and refractive surgery. 36(1)
To quantify the benefits of expedited cataract surgery in improving visual acuity and reducing fall-related injuries in the older population.Developmental Neurosciences and Child Health: Neurons to Neighbourhoods, Vancouver, British Columbia, Canada.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b08bb2bccecc93963ba47e9bdc1e9a6e
https://pubmed.ncbi.nlm.nih.gov/20117700
https://pubmed.ncbi.nlm.nih.gov/20117700
Publikováno v:
The Journal of biological chemistry. 283(43)
The role of protein-tyrosine phosphatase alpha (PTPalpha) in mast cell function was investigated in tissues and cells from PTPalpha-deficient mice. Bone marrow-derived mast cells (BMMCs) lacking PTPalpha exhibit defective stem cell factor (SCF)-depen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::016088f516cceb62aa30268e4f8b4b4e
https://pubmed.ncbi.nlm.nih.gov/18725415
https://pubmed.ncbi.nlm.nih.gov/18725415
Autor:
Lionel A. Samayawardhena, Toshiaki Kawakami, Christian M. Udell, Andrew W.B. Craig, Yuko Kawakami
Publikováno v:
The Journal of biological chemistry. 281(30)
Mast cells express the high affinity IgE receptor FcepsilonRI, which upon aggregation by multivalent antigens elicits signals that cause rapid changes within the mast cell and in the surrounding tissue. We previously showed that FcepsilonRI aggregati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e335a0ad647c0eea692ee1a5fcd96c21
https://pubmed.ncbi.nlm.nih.gov/16731527
https://pubmed.ncbi.nlm.nih.gov/16731527
Publikováno v:
Blood. 106:3887-3887
The c-Kit receptor protein-tyrosine kinase (PTK) is required for mast cell differentiation and function. Signalling by c-Kit normally depends on binding its ligand, Stem Cell Factor (SCF). However, several constitutively activating mutations in c-Kit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7d4ee12b7d1d120c5243fccba461fb42
https://doi.org/10.1182/blood.v106.11.3887.3887
https://doi.org/10.1182/blood.v106.11.3887.3887