Zobrazeno 1 - 10
of 192
pro vyhledávání: '"Lionel, Apetoh"'
Autor:
George Alzeeb, Corinne Tortorelli, Jaqueline Taleb, Fanny De Luca, Benoit Berge, Chloé Bardet, Emeric Limagne, Marion Brun, Lionel Chalus, Benoit Pinteur, Paul Bravetti, Céline Gongora, Lionel Apetoh, Francois Ghiringhelli
Publikováno v:
Frontiers in Oncology, Vol 14 (2024)
Colorectal cancer (CRC) remains a significant global health burden, emphasizing the need for innovative treatment strategies. 95% of the CRC population are microsatellite stable (MSS), insensitive to classical immunotherapies such as anti-PD-1; on th
Externí odkaz:
https://doaj.org/article/0115fec381ae4240a991d78a41f7e83c
Publikováno v:
Cell Stress, Vol 7, Iss 11, Pp 95-104 (2023)
Adoptive cell therapy (ACT) can successfully treat hema-topoietic cancers but lacks efficacy against solid tumors. This is due to insufficient T cell infiltration, high tumor heterogeneity, frequent antigen loss with subsequent tumor escape, and the
Externí odkaz:
https://doaj.org/article/2f23fa1d8e844fadbf758548ff74e650
Autor:
Mégane Nascimento, Sarah Huot-Marchand, Manoussa Fanny, Marjolène Straube, Marc Le Bert, Florence Savigny, Lionel Apetoh, Jacques Van Snick, Fabrice Trovero, Mathias Chamaillard, Valérie F. J. Quesniaux, Bernhard Ryffel, Philippe Gosset, Aurélie Gombault, Nicolas Riteau, Harry Sokol, Isabelle Couillin
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Chronic obstructive pulmonary disease (COPD) is a major health issue primarily caused by cigarette smoke (CS) and characterized by breathlessness and repeated airway inflammation. NLRP6 is a cytosolic innate receptor controlling intestinal inflammati
Externí odkaz:
https://doaj.org/article/a7d159a73b8e40fbaeb58a9775e4aac6
Autor:
Robert Emmons, Lionel Apetoh, Rita Assi, Nabil Hagag, Sherif Farag, Allie Carter, Magdalena Czader, Rafat Abonnour, Yupo Ma, Huda Salman
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/eb11de965e514a4aa3aede75b2a91a8e
Autor:
Trinh-Le-Vi Kieu, Léa Pierre, Valentin Derangère, Sabrina Perrey, Caroline Truntzer, Antoine Jalil, Sébastien Causse, Emma Groetz, Adélie Dumont, Laura Guyard, Laurent Arnould, Jean-Paul Pais de Barros, Lionel Apetoh, Cédric Rébé, Emeric Limagne, Tony Jourdan, Laurent Demizieux, David Masson, Charles Thomas, François Ghiringhelli, Mickaël Rialland
Publikováno v:
Cell Death and Disease, Vol 13, Iss 9, Pp 1-18 (2022)
Abstract Metastatic breast cancer cannot be cured, and alteration of fatty acid metabolism contributes to tumor progression and metastasis. Here, we were interested in the elongation of very long-chain fatty acids protein 5 (Elovl5) in breast cancer.
Externí odkaz:
https://doaj.org/article/e46e8fef42814a68866b78b5481c0414
Autor:
Daria Vinokurova, Lionel Apetoh
Publikováno v:
Biomolecules, Vol 13, Iss 4, p 670 (2023)
PD-1 blockade rescues failing anticancer immune responses, resulting in durable remissions in some cancer patients. Cytokines such as IFNγ and IL-2 contribute to the anti-tumor effect of PD-1 blockade. IL-9 was identified over the last decade as a c
Externí odkaz:
https://doaj.org/article/1efe9135894c49bd833fc4712809bfd4
Autor:
Pauline Soulas-Sprauel, Bernhard Ryffel, Corentin Richard, Romain Boidot, Elise Jacquin, Raphael Carapito, Richard A Flavell, Frederique Vegran, Tiffany Martin, Isis Benoit-Lizon, Thaiz Rivera Vargas, Aurélie Roussey, Ludivine Dal Zuffo, Andréa Melis, Daria Vinokurova, Sayyed Hamed Shahoei, Alvaro Baeza Garcia, Cassandre Pignol, Stéphane Giorgiutti, Eric R Nelson, Toby Lawrence, Lionel Apetoh
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 10, Iss 1 (2022)
Externí odkaz:
https://doaj.org/article/010efbccc7be494cbe7e79e2e8c14071
Autor:
Yingying Shen, Zhengbo Song, Xinliang Lu, Zeyu Ma, Chaojie Lu, Bei Zhang, Yinghu Chen, Meng Duan, Lionel Apetoh, Xu Li, Jufeng Guo, Ying Miao, Gensheng Zhang, Diya Yang, Zhijian Cai, Jianli Wang
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Fas signalling induces apoptosis of activated T cells to maintain immune homeostasis. Here the authors show that Fas also induces PKC-β activation to promote NF-κB-mediated TH9 cell differentiation, while p38 activation by PKC-β antagonizes this e
Externí odkaz:
https://doaj.org/article/8fa021e49b09489b82dc2c0a56718b53
Autor:
Peng Liu, Liwei Zhao, Jonathan Pol, Sarah Levesque, Adriana Petrazzuolo, Christina Pfirschke, Camilla Engblom, Steffen Rickelt, Takahiro Yamazaki, Kristina Iribarren, Laura Senovilla, Lucillia Bezu, Erika Vacchelli, Valentina Sica, Andréa Melis, Tiffany Martin, Lin Xia, Heng Yang, Qingqing Li, Jinfeng Chen, Sylvère Durand, Fanny Aprahamian, Deborah Lefevre, Sophie Broutin, Angelo Paci, Amaury Bongers, Veronique Minard-Colin, Eric Tartour, Laurence Zitvogel, Lionel Apetoh, Yuting Ma, Mikael J. Pittet, Oliver Kepp, Guido Kroemer
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Certain chemotherapeutic agents can exert their anticancer effect through indirect immune-dependent mechanism. Here, the authors screen a library of tyrosine kinase inhibitors and show that crizotinib is an effective stimulator of immunogenic cell de
Externí odkaz:
https://doaj.org/article/228ee56caf814e7fbcca341ed093aaed
Autor:
Sulayman Benmerzoug, Stéphanie Rose, Badreddine Bounab, David Gosset, Laure Duneau, Pauline Chenuet, Lucile Mollet, Marc Le Bert, Christopher Lambers, Silvana Geleff, Michael Roth, Louis Fauconnier, Delphine Sedda, Clarisse Carvalho, Olivier Perche, David Laurenceau, Bernhard Ryffel, Lionel Apetoh, Ahmet Kiziltunc, Hakan Uslu, Fadime Sultan Albez, Metin Akgun, Dieudonnée Togbe, Valerie F. J. Quesniaux
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Silica particles induce intereukin-1 (IL-1) response to contribute to lung inflammation, but the underlying mechanism is unclear. Here the authors show that silica induces cell death and release of mitochondria and genomic DNA, which are sensed by ST
Externí odkaz:
https://doaj.org/article/9888d37e2d5a425d97df7c19aed7823f