Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Linyue Shang"'
Autor:
Linyue Shang, Huimei Wei, Jing Deng, Madeline J. Stewart, Johnathan E. LeSaint, Annet Kyomuhangi, Shawn Park, Elise C. Maul, Chang-Guo Zhan, Fang Zheng
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract It is recognized as a promising therapeutic strategy for cocaine use disorder to develop an efficient enzyme which can rapidly convert cocaine to physiologically inactive metabolites. We have designed and discovered a series of highly effici
Externí odkaz:
https://doaj.org/article/eeaa4ba4e86944dab6007d0ff59edf53
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Cocaine is a widely abused, hepatotoxic drug without an FDA-approved pharmacotherapy specific for cocaine addiction or overdose. It is recognized as a promising therapeutic strategy to accelerate cocaine metabolism which can convert cocaine
Externí odkaz:
https://doaj.org/article/633be584821d45af9194da0d29a4dd35
Publikováno v:
Toxicology Reports, Vol 9, Iss , Pp 1586-1594 (2022)
As most cocaine users drink alcohol, it is interesting to understand how a non-lethal dose of alcohol affects the metabolism and toxicity of cocaine. In this study, we examined the correlation between dose-dependent toxicity and the metabolism/pharma
Externí odkaz:
https://doaj.org/article/1825224d5abf4b17ae0f8f868163f1be
Publikováno v:
Organic & Biomolecular Chemistry. 21:3650-3659
Combined molecular modeling, and in vitro and in vivo activity assays have consistently demonstrated that enzyme E30-6, can efficiently hydrolyze not only cocaine itself, but also all of its toxic metabolites including cocaethylene and norcocaethylen
Autor:
Fang Zheng, Zhenyu Jin, Jing Deng, Xiabin Chen, Xirong Zheng, Guojun Wang, Kyungbo Kim, Linyue Shang, Ziyuan Zhou, Chang-Guo Zhan
Publikováno v:
Bioconjugate Chemistry. 33:1340-1349
It is particularly challenging to develop a truly effective pharmacotherapy for cocaine use disorder (CUD) treatment. Accelerating cocaine metabolism
Publikováno v:
Addiction biology. 27(6)
As well known, cocaine induces stimulant effects and dopamine transporter (DAT) trafficking to the plasma membrane of dopaminergic neurons. In the present study, we examined cocaine-induced hyperactivity along with cocaine-induced DAT trafficking and
Recovery of dopaminergic system after cocaine exposure and impact of a long‐acting cocaine hydrolase
Publikováno v:
Addict Biol
Dysregulation of dopamine transporters (DAT) within the dopaminergic system is an important biomarker of cocaine exposure. Depending on cocaine amount in-taken, one-time exposure in rats could lead to most (>95% of total) of DAT translocating to plas
Publikováno v:
Addict Biol
Cocaine blocks dopamine uptake via dopamine transporter (DAT) on plasma membrane of neuron cells and, as a result, produces the high and induces DAT trafficking to plasma membrane which contributes to the drug seeking or craving. In this study, we fi
Publikováno v:
Scientific Reports
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Scientific Reports, Vol 10, Iss 1, Pp 1-10 (2020)
Cebranopadol is known as a highly potent analgesic. Recent studies also demonstrated that administration of cebranopadol significantly decreased cocaine self-administration and significantly reduced cue-induced cocaine-seeking behaviors in rats. Howe
Reengineering of Albumin-Fused Cocaine Hydrolase CocH1 (TV-1380) to Prolong Its Biological Half-Life
Autor:
Zhenyu Jin, Jing Deng, Shuo Zhou, Huimei Wei, Chang-Guo Zhan, Linyue Shang, Fang Zheng, Yingting Cai
Publikováno v:
AAPS J
Therapeutic treatment of cocaine toxicity or addiction is a grand medical challenge. As a promising therapeutic strategy for treatment of cocaine toxicity and addiction to develop a highly efficient cocaine hydrolase (CocH) capable of accelerating co