Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Linyuan Peng"'
CRISPR screening identifies PRMT1 as a key pro-ferroptotic gene via a two-layer regulatory mechanism
Autor:
Xin Zhang, Yajun Duan, Su Li, Zhenyuan Zhang, Linyuan Peng, Xiaoyu Ma, Tianzhi Wang, Siliang Xiang, Guo Chen, Danyang Zhou, Desheng Lu, Minxian Qian, Zhongyuan Wang
Publikováno v:
Cell Reports, Vol 43, Iss 9, Pp 114662- (2024)
Summary: Ferroptosis is a form of nonapoptotic cell death characterized by iron-dependent peroxidation of polyunsaturated phospholipids. However, much remains unknown about the regulators of ferroptosis. Here, using CRISPR-Cas9-mediated genetic scree
Externí odkaz:
https://doaj.org/article/432c5b3f912d4d2f841128c064ba7330
Autor:
Kai Wang, Xin Zhang, Yufei Fan, Liang Zhou, Yajun Duan, Su Li, Zhongkan Sun, Chunqian Zhang, Haoyu Yang, Wenxiu Yuan, Linyuan Peng, Xiaoyu Ma, Siliang Xiang, Tianzhi Wang, Mei Yang, Zhenyuan Zhang, Jiaxuan Wang, Zhongyuan Wang, Minxian Qian
Publikováno v:
Redox Biology, Vol 78, Iss , Pp 103419- (2024)
The clinical success of KRASG12C inhibitors (G12Ci) including AMG510 and MRTX849 is limited by the eventual development of acquired resistance. A novel and effective treatment to revert or target this resistance is urgent. To this end, we established
Externí odkaz:
https://doaj.org/article/95a1d21060214f1fb388868733798e74
Autor:
Linyuan Peng, Liang Zhou, Huan Li, Xin Zhang, Su Li, Kai Wang, Mei Yang, Xiaoyu Ma, Danlan Zhang, Siliang Xiang, Yajun Duan, Tianzhi Wang, Chunmeng Sun, Chen Wang, Desheng Lu, Minxian Qian, Zhongyuan Wang
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114003- (2024)
Summary: The major histocompatibility complex class I (MHC class I)-mediated tumor antigen processing and presentation (APP) pathway is essential for the recruitment and activation of cytotoxic CD8+ T lymphocytes (CD8+ CTLs). However, this pathway is
Externí odkaz:
https://doaj.org/article/5115bbac385b4c26b93bf2fb64d54e93
Autor:
Jie Sun, Ming Wang, Yaqi Zhong, Xuan Ma, Shimin Sun, Chenzhong Xu, Linyuan Peng, Guo Li, Liting Zhang, Zuojun Liu, Ding Ai, Baohua Liu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Monitoring the aging process in vivo is challenging. Here the authors generate a Glb1 +/m‒Glb1-2A-mCherry (GAC) reporter mouse model, where the GAC signal is consistently correlated with established biomarkers of cellular senescence, cardiac hypert
Externí odkaz:
https://doaj.org/article/790afbfd48bd4a7b9522812603435f76
Autor:
Jian Dai, Linyuan Peng
Publikováno v:
Aerospace, Vol 9, Iss 9, p 501 (2022)
In this study, supersonic gaseous detonation initiation and propagation by single- and symmetric-jets are compared, and the effects of symmetric-jets of different intensities on the detonation are further investigated to obtain a more comprehensive u
Externí odkaz:
https://doaj.org/article/c75787a9db734bfb970c627d872695ff
Autor:
Fanbiao Meng, Minxian Qian, Bin Peng, Linyuan Peng, Xiaohui Wang, Kang Zheng, Zuojun Liu, Xiaolong Tang, Shuju Zhang, Shimin Sun, Xinyue Cao, Qiuxiang Pang, Bosheng Zhao, Wenbin Ma, Zhou Songyang, Bo Xu, Wei-Guo Zhu, Xingzhi Xu, Baohua Liu
Publikováno v:
eLife, Vol 9 (2020)
The DNA damage response (DDR) is a highly orchestrated process but how double-strand DNA breaks (DSBs) are initially recognized is unclear. Here, we show that polymerized SIRT6 deacetylase recognizes DSBs and potentiates the DDR in human and mouse ce
Externí odkaz:
https://doaj.org/article/7953ab8485c34454b0b707bc2079b45b
Autor:
Minxian Qian, Zuojun Liu, Linyuan Peng, Xiaolong Tang, Fanbiao Meng, Ying Ao, Mingyan Zhou, Ming Wang, Xinyue Cao, Baoming Qin, Zimei Wang, Zhongjun Zhou, Guangming Wang, Zhengliang Gao, Jun Xu, Baohua Liu
Publikováno v:
eLife, Vol 7 (2018)
DNA damage accumulates with age (Lombard et al., 2005). However, whether and how robust DNA repair machinery promotes longevity is elusive. Here, we demonstrate that ATM-centered DNA damage response (DDR) progressively declines with senescence and ag
Externí odkaz:
https://doaj.org/article/383ba454fe734d3584b6f2a37d517788
Publikováno v:
In Aerospace Science and Technology November 2021 118
Akademický článek
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Autor:
Jie Sun, Ming Wang, Yaqi Zhong, Xuan Ma, Shimin Sun, Chenzhong Xu, Linyuan Peng, Guo Li, Liting Zhang, Zuojun Liu, Ding Ai, Baohua Liu
Publikováno v:
Nature communications. 13(1)
The progressive decline of physiological function and the increased risk of age-related diseases challenge healthy aging. Multiple anti-aging manipulations, such as senolytics, have proven beneficial for health; however, the biomarkers that label in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::098927390cd1de21a55d861d768d24e7
https://pubmed.ncbi.nlm.nih.gov/36396643
https://pubmed.ncbi.nlm.nih.gov/36396643