Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Linyuan, Ma"'
Autor:
Linyuan Ma, Jinxue Ruan, Jun Song, Luan Wen, Dongshan Yang, Jiangyang Zhao, Xiaofeng Xia, Y. Eugene Chen, Jifeng Zhang, Jie Xu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-11 (2020)
Cas9 fused to DNA damage repair proteins can improve rates of gene knock-in but the chimeric protein is often large. Here the authors fuse Cas9 to a minimal Brex27 motif from BRCA2 consisting of thirty-six amino acids to enhance the efficacy and safe
Externí odkaz:
https://doaj.org/article/58d62b4781c84e8aa9e7b4d0d8b4512d
Autor:
Jinxue Ruan, Hiroyuki Hirai, Dongshan Yang, Linyuan Ma, Xia Hou, Hong Jiang, Hongguang Wei, Carthic Rajagopalan, Hongmei Mou, Guoshun Wang, Jifeng Zhang, Kui Li, Yuqing E. Chen, Fei Sun, Jie Xu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 16, Iss , Pp 73-81 (2019)
Cystic fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Nuclease-mediated precise gene editing (PGE) represents a promising therapy for CF, for which an
Externí odkaz:
https://doaj.org/article/a456badb163c4c67808cc465e0c667bc
Autor:
Linyuan Ma, Yuzhe Wang, Haitao Wang, Yiqing Hu, Jingyao Chen, Tan Tan, Man Hu, Xiaojuan Liu, Ran Zhang, Yiming Xing, Yiqiang Zhao, Xiaoxiang Hu, Ning Li
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-11 (2018)
Abstract Efficient transgene expression in recipient cells constitutes the primary step in gene therapy. However, random integration in host genome comprises too many uncertainties. Our study presents a strategy combining bioinformatics and functiona
Externí odkaz:
https://doaj.org/article/e4e5e16e3fb34d098b20761d1fcbc221
Autor:
Kathleen A. Christie, Jimmy A. Guo, Rachel A. Silverstein, Roman M. Doll, Megumu Mabuchi, Hannah E. Stutzman, Jiecong Lin, Linyuan Ma, Russell T. Walton, Luca Pinello, G. Brett Robb, Benjamin P. Kleinstiver
Publikováno v:
Nature Biotechnology. 41:409-416
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d76210e861acf8181c3af196e0bc046a
https://doi.org/10.1038/s41587-022-01492-y
https://doi.org/10.1038/s41587-022-01492-y
Autor:
Bo Yang, Linyuan Ma, Yui Koike, Brooke Pallas, Ying Yang, Mark J. Hoenerhoff, Tomonari Koike, Cheng Deng, Jifeng Zhang, Jie Xu, Y. Eugene Chen, Changzhi Zhao, Luan Wen, Jun Song, Patrick A Lester, Dongshan Yang
Publikováno v:
Stem Cell Reports
Summary Loss-of-function mutations in the forkhead box N1 (FOXN1) gene lead to nude severe combined immunodeficiency, a rare inherited syndrome characterized by athymia, severe T cell immunodeficiency, congenital alopecia, and nail dystrophy. We rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::31909ed8b84b52ba339878069ebcfc4f
http://europepmc.org/articles/PMC7940256
http://europepmc.org/articles/PMC7940256
Autor:
Kathleen A. Christie, Jimmy A. Guo, Rachel A. Silverstein, Roman M. Doll, Megumu Mabuchi, Hannah E. Stutzman, Linyuan Ma, G. Brett Robb, Benjamin P. Kleinstiver
While restriction enzymes (REs) remain the gold-standard for manipulating DNA in vitro, they have notable drawbacks including a dependence on short binding motifs that constrain their ability to cleave DNA substrates. Here we overcome limitations of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::90883b1070d6818cc6bf7499320c9c40
https://doi.org/10.1101/2022.01.11.474553
https://doi.org/10.1101/2022.01.11.474553
Autor:
Kathleen A, Christie, Jimmy A, Guo, Rachel A, Silverstein, Roman M, Doll, Megumu, Mabuchi, Hannah E, Stutzman, Jiecong, Lin, Linyuan, Ma, Russell T, Walton, Luca, Pinello, G Brett, Robb, Benjamin P, Kleinstiver
Publikováno v:
Nature biotechnology.
Methods for in vitro DNA cleavage and molecular cloning remain unable to precisely cleave DNA directly adjacent to bases of interest. Restriction enzymes (REs) must bind specific motifs, whereas wild-type CRISPR-Cas9 or CRISPR-Cas12 nucleases require
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::2bd132efe9eb805fbd83df8e578a7a56
https://pubmed.ncbi.nlm.nih.gov/36203014
https://pubmed.ncbi.nlm.nih.gov/36203014
Autor:
Linyuan Ma, Dongshan Yang, Hiroyuki Hirai, Hongmei Mou, Hong Jiang, Kui Li, Fei Sun, Yuqing E. Chen, Jifeng Zhang, Jinxue Ruan, Carthic Rajagopalan, Guoshun Wang, Jie Xu, Xia Hou, Hongguang Wei
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 16, Iss, Pp 73-81 (2019)
Molecular Therapy: Nucleic Acids, Vol 16, Iss, Pp 73-81 (2019)
Cystic fibrosis (CF) is a lethal autosomal recessive disease caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Nuclease-mediated precise gene editing (PGE) represents a promising therapy for CF, for which an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63a0b8faa7cc3f02e60a8ff5eff1aa27
https://doi.org/10.1016/j.omtn.2019.02.006
https://doi.org/10.1016/j.omtn.2019.02.006
Autor:
Sun Zhaolin, Wenjie Liu, Xiaojuan Liu, Ning Li, Jie Zhong, Yaofeng Zhao, Xiaoxiang Hu, Yiming Xing, Dengke Pan, Chen Jingyao, Linlin Zhang, Tan Tan, Jianhui Bai, Yunlong Zou, Yiqing Hu, Tao Feng, Kegong Tian, Man Hu, Haitao Wang, Linyuan Ma, Xiaofei Bai, Dawei Yu
Publikováno v:
International Journal of Biological Sciences. 15:481-492
Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious disease and the most economically important disease of the swine industry worldwide. Highly pathogenic-PRRS virus (HP-PRRSV) is a variant of PRRSV, which caused high morbidit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ff0908d0e319dba7b50fb93629615a58
https://doi.org/10.7150/ijbs.25862
https://doi.org/10.7150/ijbs.25862
Autor:
Nan Xiping, Meng Yue, Tian Zhigang, Yang Zhiqiang, Xianpeng Zeng, Sun Hongrui, Liu Xiangying, Lining Kang, Linyuan Ma, Jieying Fan
Publikováno v:
Food chemistry. 367
In order to determine the mechanisms underlying resistant starch formation, three treatments were used to prepare resistant starch from purple sweet potato. The resistant starch yield, amylose content, chain length distribution, thermal properties, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5dc4a6f9366efbbe160df3ddd34ba312
https://pubmed.ncbi.nlm.nih.gov/34371274
https://pubmed.ncbi.nlm.nih.gov/34371274