Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Linyee Shum"'
Publikováno v:
Journal of Pharmaceutical and Biomedical Analysis. 37:757-762
A highly sensitive method was developed and validated for determining the free fraction of flunarizine in human plasma. Equilibrium dialysis was used for the separation of free (unbound) drug and liquid chromatography/tandem mass spectrometry (LC-MS/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f70add61b0d365ab41b6bc10a4b19fa
https://doi.org/10.1016/j.jpba.2004.10.050
https://doi.org/10.1016/j.jpba.2004.10.050
Publikováno v:
Journal of Chromatography B. 814:201-207
Glycyrrhizin (GLY) which has been widely used in traditional Chinese medicinal preparation possesses various pharmacological effects. In order to investigate the pharmacokinetic behavior of GLY in human after oral administration of GLY or licorice ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e29137a2c3dbe0ead5e1aa7ed5c442c
https://doi.org/10.1016/j.jchromb.2004.10.026
https://doi.org/10.1016/j.jchromb.2004.10.026
Publikováno v:
Journal of Chromatography B. 788:159-166
Cromolyn sodium is a safe compound with potent anti-allergic properties when used locally or topically. Clinical data from systemic exposure is not available because of the poor GI absorption when given orally. In order to evaluate a new approach to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57f368731ef676fea1d82331a3ce24d3
https://doi.org/10.1016/s1570-0232(02)01041-3
https://doi.org/10.1016/s1570-0232(02)01041-3
Autor:
Susan M. Rowe, Nhung H Nguyen, Nancy J. Rogers, Linyee Shum, Bruce J. Aungst, Munir A. Hussain, Susan J White
Publikováno v:
International Journal of Pharmaceutics. 156:79-88
DMP 323 is the first clinical candidate from a novel series of HIV protease inhibitors having a cyclic urea structural backbone. In dogs dosed with glycol-based vehicles, DMP 323 was approximately 50% orally bioavailable after a 100 mg dose, but bioa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb595305ba919f9a770b404ec846f803
https://doi.org/10.1016/s0378-5173(97)00189-0
https://doi.org/10.1016/s0378-5173(97)00189-0
Publikováno v:
Epilepsia. 38:1026-1031
PURPOSE: Studies were conducted to establish the safety, tolerability, and pharmacokinetics of the antiepileptic drug (AED) ganaxolone. Ganaxolone belongs to a novel class of neuroactive steroids called epalons, which specifically modulate the gamma-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8ed55a9b388d5b7591259a0cac2bbaa
https://doi.org/10.1111/j.1528-1157.1997.tb01486.x
https://doi.org/10.1111/j.1528-1157.1997.tb01486.x
Autor:
Anna F. Davidson, Linyee Shum, Paul J. Widner, Irma H. Benedek, Henry J. Pieniaszek, Walter Flamenbaum, Cynthia A. Robinson
Publikováno v:
The Journal of Clinical Pharmacology. 36:1161-1168
Sixteen healthy male volunteers completed a nonrandomized, sequential, three-phase study. The three phases were 1) moricizine at 250 mg every 8 hours for 7 days with 12 days washout; 2) diltiazem at 60 mg every 8 hours for 7 days; and 3) concomitant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81e7ed0a70c49188cd06eb35db058dbb
https://doi.org/10.1002/j.1552-4604.1996.tb04171.x
https://doi.org/10.1002/j.1552-4604.1996.tb04171.x
Publikováno v:
Journal of Chromatography B: Biomedical Sciences and Applications. 678:303-308
Extraction of DMP 450 from plasma was performed with C2 solid-phase extraction columns, using 0.1 M ammonium acetate in 90% methanol to elute DMP 450. The extraction recovery over the range of 10 to 10 000 ng/ml averaged 81.0, 96.2, 77.4, 95.2 and 68
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e056fce745c0b52721f41d5bc8f3067b
https://doi.org/10.1016/0378-4347(95)00478-5
https://doi.org/10.1016/0378-4347(95)00478-5
Autor:
Linyee Shum, Wuyi Zha
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 902
A selective high performance liquid chromatography-tandem mass spectrometric (LC-MS/MS) method for the simultaneous determination of oxymorphone and its active metabolite 6-OH-oxymorphone in human plasma was developed and validated using oxymorphone-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b742f5cd1e601b45cfa1f7f9ab88d023
https://pubmed.ncbi.nlm.nih.gov/22795571
https://pubmed.ncbi.nlm.nih.gov/22795571
Autor:
Linyee Shum, Wuyi Zha
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 906
A selective and sensitive high performance liquid chromatography–tandem mass spectrometric method was developed for the analysis of azelastine and its major metabolite, desmethylazelastine, in human plasma. Azelastine- 13 C, d 3 was used as interna
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b609db39a2b908b0811f50c261f78fd6
https://pubmed.ncbi.nlm.nih.gov/22954967
https://pubmed.ncbi.nlm.nih.gov/22954967
Publikováno v:
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences. 801(2)
Glipizide and rosiglitazone are widely used to treat Type 2 diabetes. In order to investigate drug-drug protein binding interaction between glipizide and rosiglitazone, a method was developed and validated for simultaneously determining the free (unb
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac7cccff18acb1850f08dbf641b9396
https://pubmed.ncbi.nlm.nih.gov/14751795
https://pubmed.ncbi.nlm.nih.gov/14751795