Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Linxiang Lan"'
Autor:
E Josue Ruiz, Adan Pinto-Fernandez, Andrew P Turnbull, Linxiang Lan, Thomas M Charlton, Hannah C Scott, Andreas Damianou, George Vere, Eva M Riising, Clive Da Costa, Wojciech W Krajewski, David Guerin, Jeffrey D Kearns, Stephanos Ioannidis, Marie Katz, Crystal McKinnon, Jonathan O'Connell, Natalia Moncaut, Ian Rosewell, Emma Nye, Neil Jones, Claire Heride, Malte Gersch, Min Wu, Christopher J Dinsmore, Tim R Hammonds, Sunkyu Kim, David Komander, Sylvie Urbe, Michael J Clague, Benedikt M Kessler, Axel Behrens
Publikováno v:
eLife, Vol 10 (2021)
Lung squamous cell carcinoma (LSCC) is a considerable global health burden, with an incidence of over 600,000 cases per year. Treatment options are limited, and patient’s 5-year survival rate is less than 5%. The ubiquitin-specific protease 28 (USP
Externí odkaz:
https://doaj.org/article/eeea231092ca40e880a44f8ed5d20d8d
Autor:
Huafu Li, Chunming Wang, Linxiang Lan, Wenhui Wu, Ian Evans, E. Josue Ruiz, Leping Yan, Zhijun Zhou, Joaquim M. Oliveira, Rui L. Reis, Zhenran Hu, Wei Chen, Axel Behrens, Yulong He, Changhua Zhang
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Oxaliplatin (OXA) resistance in the treatment of different types of cancer is an important and complex problem. The culture of tumor organoids derived from gastric cancer can help us to provide a deeper understanding of the underlying mechanisms that
Externí odkaz:
https://doaj.org/article/1a708a1fd2ea485db52e0b41bef62450
Autor:
E. Josue Ruiz, Linxiang Lan, Markus Elmar Diefenbacher, Eva Madi Riising, Clive Da Costa, Atanu Chakraborty, Joerg D. Hoeck, Bradley Spencer-Dene, Gavin Kelly, Jean-Pierre David, Emma Nye, Julian Downward, Axel Behrens
Publikováno v:
JCI Insight, Vol 6, Iss 13 (2021)
The AP-1 transcription factor c-Jun is required for Ras-driven tumorigenesis in many tissues and is considered as a classical proto-oncogene. To determine the requirement for c-Jun in a mouse model of K-RasG12D–induced lung adenocarcinoma, we induc
Externí odkaz:
https://doaj.org/article/d1bdf75630574d7b9e1c28b13a237cf7
Autor:
Özlem Akilli Öztürk, Hubert Pakula, Jolanta Chmielowiec, Jingjing Qi, Simone Stein, Linxiang Lan, Yoshiteru Sasaki, Klaus Rajewsky, Walter Birchmeier
Publikováno v:
Cell Reports, Vol 13, Iss 3, Pp 561-572 (2015)
Gab1 is a scaffold protein that acts downstream of receptor tyrosine kinases. Here, we produced conditional Gab1 mutant mice (by K14- and Krox20-cre) and show that Gab1 mediates crucial signals in the control of both the hair cycle and the self-renew
Externí odkaz:
https://doaj.org/article/f2b5ea800f4f49809bc188cdff8eafcd
Autor:
Linxiang Lan, Axel Behrens
Publikováno v:
Cancer Research. 83:170-172
The cancer stem cell (CSC) model states that heterogeneous tumor cell populations are organized in a hierarchical manner, with a small population of CSCs at the apex. These CSCs are capable of self-renewal and giving rise to other cancer cell populat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6e2b741de3cacb6c3a0e9e80b5323a22
https://doi.org/10.1158/0008-5472.can-22-2053
https://doi.org/10.1158/0008-5472.can-22-2053
Autor:
Walter Birchmeier, Yaron Fuchs, Elle Koren, Elisabetta Marangoni, Sophie Château-Joubert, Kamil Lisek, Alexandro Landshammer, Clemens Messerschmidt, Linxiang Lan, Philipp Mertins, Oliver Popp, Regina Vogel, Hazel M. Quinn
Source file related to figure 6
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4998185de89640bca75bfcea9fbaa03c
https://doi.org/10.1158/0008-5472.22430280
https://doi.org/10.1158/0008-5472.22430280
Autor:
Walter Birchmeier, Yaron Fuchs, Elle Koren, Elisabetta Marangoni, Sophie Château-Joubert, Kamil Lisek, Alexandro Landshammer, Clemens Messerschmidt, Linxiang Lan, Philipp Mertins, Oliver Popp, Regina Vogel, Hazel M. Quinn
Supplementary figure related to figure 3. Supplementary Fig. 3. Wnt-Met signalling induces YAP-dependent luminal-to-basal transition.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ddbe1c1e10fd2ec66c41237e23d44d
https://doi.org/10.1158/0008-5472.22430271.v1
https://doi.org/10.1158/0008-5472.22430271.v1
Autor:
Walter Birchmeier, Annika Wulf-Goldenberg, Regina Vogel, Jane D. Holland, Linxiang Lan, Guus J.J.E. Heynen, Hazel M. Quinn, Giovanni Valenti
List of primers and antibodies used
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9418524956510d55a47fd151083e92b1
https://doi.org/10.1158/0008-5472.22415967.v1
https://doi.org/10.1158/0008-5472.22415967.v1
Autor:
Walter Birchmeier, Yaron Fuchs, Elle Koren, Elisabetta Marangoni, Sophie Château-Joubert, Kamil Lisek, Alexandro Landshammer, Clemens Messerschmidt, Linxiang Lan, Philipp Mertins, Oliver Popp, Regina Vogel, Hazel M. Quinn
Supplementary material and methods and Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::560c95ff11c5715133e550dacaa82cab
https://doi.org/10.1158/0008-5472.22430256
https://doi.org/10.1158/0008-5472.22430256
Autor:
Walter Birchmeier, Yaron Fuchs, Elle Koren, Elisabetta Marangoni, Sophie Château-Joubert, Kamil Lisek, Alexandro Landshammer, Clemens Messerschmidt, Linxiang Lan, Philipp Mertins, Oliver Popp, Regina Vogel, Hazel M. Quinn
Targeting cancer stem cells (CSC) can serve as an effective approach toward limiting resistance to therapies. While basal-like (triple-negative) breast cancers encompass cells with CSC features, rational therapies remain poorly established. We show h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f089ac3021b3830d56e57de739df5bf2
https://doi.org/10.1158/0008-5472.c.6513579.v1
https://doi.org/10.1158/0008-5472.c.6513579.v1