Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Linxiang Cai"'
Publikováno v:
Molecules, Vol 29, Iss 13, p 3121 (2024)
The cyclic GMP-AMP synthase (cGAS)-stimulator of interferon genes (STING) pathway is pivotal in immunotherapy. Several agonists and inhibitors of the cGAS-STING pathway have been developed and evaluated for the treatment of various diseases. The agon
Externí odkaz:
https://doaj.org/article/491903ca542e43fbb18a7ace1c3fe66c
Autor:
Linxiang Cai, Ying Wang, Yayu Chen, Hanhua Chen, Tao Yang, Shuren Zhang, Zijian Guo, Xiaoyong Wang
Publikováno v:
Chemical Science. 14:4375-4389
Mn complexes act as breakers of DNA to induce DSB, as inhibitors of HDAC and PARP to impede DNA repair, and as activators of the cGAS-STING pathway to trigger immune responses, thereby stimulating T cells to suppress tumor growth in a synergic mechan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::49f5c18146de79d5511f8d4b5f516916
https://doi.org/10.1039/d2sc06036a
https://doi.org/10.1039/d2sc06036a
Autor:
Tao Yang, Shuren Zhang, Hao Yuan, Ying Wang, Linxiang Cai, Hanhua Chen, Xiaoyu Wang, Dongfan Song, Xiaohui Wang, Zijian Guo, Xiaoyong Wang
Publikováno v:
Angewandte Chemie International Edition. 62
Triggering receptor expressed on myeloid cells-2 (TREM2) is a key pro-tumorigenic marker of tumor-infiltrating macrophages, showing potent immunosuppressive activity in tumor microenvironment. A platinum(IV) complex OPA derived from oxaliplatin (OP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56e9c7296dcdb256242d0ad663d9e6ba
https://doi.org/10.1002/anie.202213337
https://doi.org/10.1002/anie.202213337
Autor:
Shaoping Pu, Bo Yang, Xiali Liao, Yamin Li, Xinzhong Zhang, Yanwei Cong, Yunshuang Zhong, Chunyan Jia, Chuanzhu Gao, Linxiang Cai
Publikováno v:
Applied Organometallic Chemistry. 34
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a7bfda21edc5a16ff16ec1d3b1b5cb92
https://doi.org/10.1002/aoc.5680
https://doi.org/10.1002/aoc.5680
Autor:
Yehong Tan, Hanhua Chen, Jie Zhang, Linxiang Cai, Suxing Jin, Dongfan Song, Tao Yang, Zijian Guo, Xiaoyong Wang
Publikováno v:
European Journal of Medicinal Chemistry. 229:114047
Phagocytosis of cancer cells by antigen presenting cells (APCs) is critical to activate the host's immune responses. However, the targeting ability of APCs to cancer cells is limited by the upregulation of transmembrane protein CD47 on the cancer cel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::baa34a850d34d5441ac83f93c851289a
https://doi.org/10.1016/j.ejmech.2021.114047
https://doi.org/10.1016/j.ejmech.2021.114047
Publikováno v:
Journal of Coordination Chemistry. 70:3759-3768
A series of novel dinuclear platinum(II) complexes with a chiral tetradentate ligand, (1R,1′R,2R,2′R)-N1,N1′-(1,2-phenylenebis(methylene))dicyclohexane-1,2-diamine (HL), and mono-carboxylic acid derivatives as ligands have been designed, synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a707c7a13a7cea3fd24d142eb59d231
https://doi.org/10.1080/00958972.2017.1398822
https://doi.org/10.1080/00958972.2017.1398822
Autor:
Yunxu Qian, Jian Yang, Xiali Liao, Linxiang Cai, Chuanzhu Gao, Bai Linkui, Liu Qinghua, Congtao Yu, Zhuxin Zhang, Bo Yang
Publikováno v:
European Journal of Medicinal Chemistry. 140:349-382
Since the antitumor activity of cisplatin was discovered in 1967 by Rosenberg, platinum-based anticancer drugs have played an important role in chemotherapy in clinic. Nevertheless, platinum anticancer drugs also have caused severe side effects and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5ed9d2aa5fbb040dc6871346e8ea748
https://doi.org/10.1016/j.ejmech.2017.09.034
https://doi.org/10.1016/j.ejmech.2017.09.034
Autor:
Binjun Wang, Linxiang Cai
Publikováno v:
2018 IEEE 4th Information Technology and Mechatronics Engineering Conference (ITOEC).
Aiming at the problem of illegal activities of Bitcoin, in this paper, transaction data structure of Bitcoin and data storage mechanism of Bitcoin Core (official client for Bitcoin) and are firstly analyzed, then a MapReduce-based structured method f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::87da26030c982ffdc519f7ac4b05a6fb
https://doi.org/10.1109/itoec.2018.8740574
https://doi.org/10.1109/itoec.2018.8740574
Publikováno v:
Applied Organometallic Chemistry. 32:e4228
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d44df4532b416dda3208fe8daf893f52
https://doi.org/10.1002/aoc.4228
https://doi.org/10.1002/aoc.4228