Lmo mutants reveal a novel role for circadian pacemaker neurons in cocaine-induced behaviors.

Autor: Linus T-Y Tsai, Roland J Bainton, Justin Blau, Ulrike Heberlein

Publikováno v: PLoS Biology, Vol 2, Iss 12, p e408 (2004)

Drosophila has been developed recently as a model system to investigate the molecular and neural mechanisms underlying responses to drugs of abuse. Genetic screens for mutants with altered drug-induced behaviors thus provide an unbiased approach to d

Externí odkaz: https://doaj.org/article/406cfa8270b7419fb9c84c6868638648

A single-nucleus and spatial transcriptomic atlas of the COVID-19 liver reveals topological, functional, and regenerative organ disruption in patients

Autor: Yered Pita-Juarez, Dimitra Karagkouni, Nikolaos Kalavros, Johannes C. Melms, Sebastian Niezen, Toni M. Delorey, Adam L Essene, Olga R. Brook, Deepti Pant, Disha Skelton-Badlani, Pourya Naderi, Pinzhu Huang, Liuliu Pan, Tyler Hether, Tallulah S. Andrews, Carly G.K. Ziegler, Jason Reeves, Andriy Myloserdnyy, Rachel Chen, Andy Nam, Stefan Phelan, Yan Liang, Amit Dipak Amin, Jana Biermann, Hanina Hibshoosh, Molly Veregge, Zachary Kramer, Christopher Jacobs, Yusuf Yalcin, Devan Phillips, Michal Slyper, Ayshwarya Subramanian, Orr Ashenberg, Zohar Bloom-Ackermann, Victoria M. Tran, James Gomez, Alexander Sturm, Shuting Zhang, Stephen J. Fleming, Sarah Warren, Joseph Beechem, Deborah Hung, Mehrtash Babadi, Robert F. Padera, Sonya A. MacParland, Gary D. Bader, Nasser Imad, Isaac H. Solomon, Eric Miller, Stefan Riedel, Caroline B.M. Porter, Alexandra-Chloé Villani, Linus T.-Y. Tsai, Winston Hide, Gyongyi Szabo, Jonathan Hecht, Orit Rozenblatt-Rosen, Alex K. Shalek, Benjamin Izar, Aviv Regev, Yury Popov, Z. Gordon Jiang, Ioannis S. Vlachos

Publikováno v: bioRxiv : the preprint server for biology.

The molecular underpinnings of organ dysfunction in acute COVID-19 and its potential long-term sequelae are under intense investigation. To shed light on these in the context of liver function, we performed single-nucleus RNA-seq and spatial transcri

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccd10833ef100648eb315ed90fe2285a
https://pubmed.ncbi.nlm.nih.gov/36324805

Thyroid hormone signaling promotes hepatic lipogenesis through the transcription factor ChREBP

Autor: Andrew A. Wilson, Catherine J. Tang, Lujain Al-Sowaimel, Hong Liu, Bhavna N. Desai, Jinyoung Choi, Christopher Jacobs, Yulong Fu, Anthony N. Hollenberg, Linus T.-Y. Tsai, Douglas Forrest, Danielle Tenen, David E. Cohen, Arturo Mendoza, Adriana G. Martin, Anna Lyubetskaya, Maya Logan, Mariana Acuña

Publikováno v: Sci Signal

Thyroid hormone (TH) action is essential for hepatic lipid synthesis and oxidation. Analysis of hepatocyte-specific thyroid receptor beta 1 (TRβ1) knockout mice confirmed a role for TH in stimulating de novo lipogenesis and fatty acid oxidation thro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::239bfee0f1a20c85970701346c293444
https://doi.org/10.1126/scisignal.abh3839

Ablation of adipocyte creatine transport impairs thermogenesis and causes diet-induced obesity

Autor: Janane F. Rahbani, LeeAnn C Ramsay, Petras P. Dzeja, Danielle Tenen, Gina Z. Lu, Florence Y. Dou, Bruce M. Spiegelman, Song Zhang, Lawrence Kazak, Linus T.-Y. Tsai, Mathieu Lajoie, Evan D. Rosen, Edward T. Chouchani, Ian R. Watson, Mark P. Jedrychowski, Bozena Samborska

Publikováno v: Nature metabolism

Depleting creatine levels in thermogenic adipocytes by inhibiting creatine biosynthesis reduces thermogenesis and causes obesity. However, whether creatine import from the circulation affects adipocyte thermogenesis is unknown. Here we show that dele

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdde5e1727fbf170edcc0690f6179c27
https://doi.org/10.1038/s42255-019-0035-x

A single-cell and spatial atlas of autopsy tissues reveals pathology and cellular targets of SARS-CoV-2

Autor: Stephen J. Fleming, Bo Li, Mehrtash Babadi, Katherine J. Siddle, Donald E. Ingber, Alexandra-Chloé Villani, Pritha Sen, Adam Essene, Marty Ross, Kushal K. Dey, Yiming Yang, Shamsudheen K. Vellarikkal, Olga R. Brook, Isaac H. Solomon, Phylicia Dorceus, Siddharth S. Raju, Tyler Hether, Sebastian Niezen, Dan Zollinger, Alexander Sturm, Pardis C. Sabeti, Purushothama Rao Tata, Yury Popov, Timothy L. Tickle, Ioannis S. Vlachos, Carly G. K. Ziegler, Jonathan L. Hecht, Z. Gordon Jiang, Winston Hide, James R. Stone, Rajat M. Gupta, Linus T.-Y. Tsai, Sarah Warren, Jesse M. Engreitz, Jonathan H. Chen, Victoria M. Tran, Michael Leney-Greene, Daniel T. Montoro, Michelle Siciliano, Asa Segerstolpe, Graham Heimberg, Pourya Naderi, Stefan Riedel, Alkes L. Price, Lisa A. Cosimi, Tyler Harvey, Toni Delorey, Prajan Divakar, Deborah T. Hung, Malika Sud, Joshua Gould, Rachelly Normand, Shuting Zhang, Orit Rozenblatt-Rosen, Ayshwarya Subramanian, Donna M. Fitzgerald, Steven Gazal, Devan Phillips, Cristin McCabe, Joseph M. Beechem, Nick Barkas, Erroll H. Rueckert, Dejan Juric, Hui Ma, Jason Reeves, Ellen Todres, Orr Ashenberg, Domenic Abbondanza, Alex K. Shalek, Liuliu Pan, Erica Normandin, Caroline B. M. Porter, Mari Niemi, Samouil L. Farhi, Robert S. Rogers, Deepti Pant, Gyongyi Szabo, Yered Pita-Juárez, Liat Amir-Zilberstein, Melissa Rudy, Christoph Muus, Christopher J. Pinto, Andrea Ganna, Aviv Regev, Robin Fropf, Michal Slyper, Richard M. Novak, Daniel E. McLoughlin, Jenna Pfiffner-Borges, Robert F. Padera, Eric M. Miller, Jayaraj Rajagopal, Avinash Waghray, Nir Hacohen, Karthik A. Jagadeesh, Judit Jané-Valbuena, James Gomez, Zohar Bloom-Ackermann

Publikováno v: bioRxiv

The SARS-CoV-2 pandemic has caused over 1 million deaths globally, mostly due to acute lung injury and acute respiratory distress syndrome, or direct complications resulting in multiple-organ failures. Little is known about the host tissue immune and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43a261ef5f1b07087db03ed09fb065f0
https://europepmc.org/articles/PMC7924267/