Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Linus N. Igwemezie"'
Autor:
Kenneth R. Hande, Dana S. Thompson, F. Anthony Greco, Antonius A. Miller, John D. Hainsworth, Sanjeev Kaul, Rashmi H. Barbhaiya, Nuggehally R. Srinivas, Linus N. Igwemezie, George C. Garrow, Lee P. Schacter
Publikováno v:
Clinical Pharmacology & Therapeutics. 57:499-507
Purpose To determine the maximum tolerated dose, toxicities, kinetics, and disposition of etoposide phosphate when administered as a daily 30-minute infusion for 5 days. Patients and methods Twenty-eight patients were enrolled in this phase I dose-es
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::140a9fa0a5b3b9ae1b481d7806051d37
https://doi.org/10.1016/0009-9236(95)90034-9
https://doi.org/10.1016/0009-9236(95)90034-9
Publikováno v:
Pharmaceutical Research. 12:117-123
The toxicokinetics and toxicodynamics of etoposide phosphate (BMY-40481), a water soluble phosphate ester derivative of etoposide, were investigated in beagle dogs (N = 4) following 5 min i.v. infusion doses equivalent to 57, 114 and 461 mg/m2 of eto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a307ac0c16fe22e0adadb84245079425
https://doi.org/10.1023/a:1016203107497
https://doi.org/10.1023/a:1016203107497
Autor:
Linus N. Igwemezie, Mahmoud Seyedsadr, Eric Albert, Jacqueline Randolph, Lee P. Schacter, Pedro Santabarbara, Elizabeth A. Morgenthien
Publikováno v:
Cancer Chemotherapy and Pharmacology. 34:S58-S63
Etoposide phosphate (Etopophos, BMY-40481) is a water-soluble derivative of the widely used podophyllotoxin etoposide (VP-16). The phosphate ester renders the compound water-soluble, eliminating the need for formulation in polysorbate (Tween) 80, eth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc0ebff09ac369071250cd3f90a12d63
https://doi.org/10.1007/bf00684865
https://doi.org/10.1007/bf00684865
Autor:
David Porter, B. Winograd, A. Hilary Calvert, David R. Newell, Linus N. Igwemezie, Vanaja Mummaneni, Rashmi H. Barbhaiya, Huw D. Thomas, Sanjeev Kaul
Publikováno v:
Journal of pharmacokinetics and biopharmaceutics. 24(4)
The bioequivalence of etoposide phosphate, a prodrug of etoposide, to etoposide was assessed in a randomized, crossover study in 29 patients with histologically established solid tumors that had failed conventional treatment. Cohorts of patients rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb038be8d8b880e5815ffd7524fb8791
https://pubmed.ncbi.nlm.nih.gov/9044163
https://pubmed.ncbi.nlm.nih.gov/9044163
Autor:
Michael J. Lind, K. Balmanno, Linus N. Igwemezie, G A Taylor, D. Simmonds, A.H. Calvert, R.H. Barbaiya, L. Gumbrell, Vanaja Mummaneni, F Chapman, Mark R. Proctor, Sanjeev Kaul, C.J. Charlton, B. Winograd, B. M. J. Cantwell, Michael J. Millward, C. McDaniel, David R. Newell
Publikováno v:
European journal of cancer (Oxford, England : 1990). (13-14)
Etoposide phosphate is a water-soluble prodrug of etoposide. A phase I and pharmacokinetic study has been performed over the dose range 25–110 mg/m2/day for 5 days (etoposide equivalent doses). The maximum tolerated dose (MTD) was 110 mg/m2/day for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4274162bade75f45775d280752069a5
https://pubmed.ncbi.nlm.nih.gov/8652278
https://pubmed.ncbi.nlm.nih.gov/8652278
Publikováno v:
Biomedical chromatography : BMC. 6(4)
The increased attention on the therapeutic implications of stereoisomerism has provided an impetus for the development of analytical methods for enantiomeric separation. The indirect method of separation of enantiomers as diastereomers using high per
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::100273209ee48bf666e1cfba60e19010
https://pubmed.ncbi.nlm.nih.gov/1643383
https://pubmed.ncbi.nlm.nih.gov/1643383
Publikováno v:
European journal of pharmacology. 210(3)
The antiarrhythmic actions of the racemate and enantiomers of mexiletine were studied in conscious and anaesthetised rats. Racemate or enantiomers, at 20 mg/kg i.v., had little effect on ischaemia-induced ventricular fibrillation in conscious or anae
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1daef988eb679f1be252c610aeb849b
https://pubmed.ncbi.nlm.nih.gov/1612103
https://pubmed.ncbi.nlm.nih.gov/1612103
Publikováno v:
JPEN. Journal of parenteral and enteral nutrition. 15(5)
Vancomycin usage at British Columbia's Children's Hospital has increased substantially in the Special Care Nursery as a consequence of a study demonstrating a reduced morbidity and mortality in neonates with necrotizing enterocolitis when treated wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::738b0b95eb1c8f974eafd0660d20b55f
https://pubmed.ncbi.nlm.nih.gov/1942466
https://pubmed.ncbi.nlm.nih.gov/1942466
Autor:
Michael J. Lind, D. Simmonds, L. Gumbrell, Michael Millward, Newell, C.J. Charlton, Mark R. Proctor, Alan Hilary Calvert, B. Winograd, N P Bailey, F Dore-Green, Linus N. Igwemezie, C. McDaniel
Publikováno v:
European Journal of Cancer. 29:S108
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8ea46198dccd6a39fbc4426d822055d0
https://doi.org/10.1016/0959-8049(93)91208-3
https://doi.org/10.1016/0959-8049(93)91208-3