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Akademický článek

Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes

Autor: Gunnar Ronquist, Urban Hellman, Göran Larsson, Linus Malm, Nina Gennebäck, Anders Waldenström, Stellan Mörner

Publikováno v: Journal of Extracellular Vesicles, Vol 2, Iss 0, Pp 1-8 (2013)

Exosomes are nano-sized extracellular vesicles, released from various cells, which can stimulate or repress responses in targets cells. We recently reported that cultured cardiomyocytes are able to release exosomes and that they, in turn, are involve

Externí odkaz: https://doaj.org/article/bc4b20fee10b4986a49cec49e68c544e

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Akademický článek

Growth factor PDGF-BB stimulates cultured cardiomyocytes to synthesize the extracellular matrix component hyaluronan.

Autor: Urban Hellman, Linus Malm, Li-Ping Ma, Göran Larsson, Stellan Mörner, Michael Fu, Anna Engström-Laurent, Anders Waldenström

Publikováno v: PLoS ONE, Vol 5, Iss 12, p e14393 (2010)

Hyaluronan (HA) is a glycosaminoglycan located in the interstitial space which is essential for both structural and cell regulatory functions in connective tissue. We have previously shown that HA synthesis is up-regulated in a rat model of experimen

Externí odkaz: https://doaj.org/article/23feb3de060e4518a06250ff691663b1

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Metabolomic Quality Assessment of EDTA Plasma and Serum Samples

Autor: Gunnel Tybring, Joakim Galli, Linus Malm, Britta Landin, Thomas Moritz

Publikováno v: Biopreservation and Biobanking. 14:416-423

Handling and processing of blood can significantly alter the molecular composition and consistency of biobank samples and can have a major impact on the identification of biomarkers. It is thus crucial to identify tools to determine the quality of sa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc0c3cdf1c67dfcbf02aabffd1af699d
https://doi.org/10.1089/bio.2015.0092

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Metabolite and Peptide Levels in Plasma and CSF Differentiating Healthy Controls from Patients with Newly Diagnosed Parkinson's Disease

Autor: Miles Trupp, Linus Malm, Henrik Zetterberg, Anna Wuolikainen, Ogonna Obudulu, Kaj Blennow, Pär Jonsson, Annika Öhrfelt, Henrik Antti, Thomas Moritz, Jan Linder, Lars Forsgren

Publikováno v: Journal of Parkinson's Disease. 4:549-560

Parkinson's disease (PD) is a progressive, multi-focal neurodegenerative disease for which there is no effective disease modifying treatment. A critical requirement for designing successful clinical trials is the development of robust and reproducibl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0888f3d24ff7a6899cc547f254fb3f2d
https://doi.org/10.3233/jpd-140389

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Using OPLS-DA to find new hypotheses in vast amounts of gene expression data — Studying the progression of cardiac hypertrophy in the heart of aorta ligated rat

Autor: Nina Gennebäck, Anders Waldenström, Stellan Mörner, Linus Malm, Urban Hellman

Publikováno v: Gene. 522:27-36

One of the great problems facing science today lies in data mining of the vast amount of data. In this study we explore a new way of using orthogonal partial least squares-discrimination analysis (OPLS-DA) to analyze multidimensional data. Myocardial

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::446d134a6070edc598f0d7ee94cc1baf
https://doi.org/10.1016/j.gene.2013.03.018

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Growth factor stimulation of cardiomyocytes induces changes in the transcriptional contents of secreted exosomes

Autor: Göran Larsson, Linus Malm, Stellan Mörner, Urban Hellman, Nina Gennebäck, Gunnar Ronquist, Anders Waldenström

Publikováno v: Journal of Extracellular Vesicles, Vol 2, Iss 0, Pp 1-8 (2013)
Journal of Extracellular Vesicles; Vol 2 (2013) incl Supplements
Journal of Extracellular Vesicles

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ffb096bff47231fc2fd0984b48ddff1
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-59474

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Size determination of hyaluronan using a gas-phase electrophoretic mobility molecular analysis

Autor: Linus Malm, Urban Hellman, Göran Larsson

Publikováno v: Glycobiology. 22(1)

Hyaluronan (HA) is a linear non-sulfated polysaccharide mainly found in the extracellular matrix. The size of HA can vary from a few disaccharides up to at least 25,000 units, reaching molecular weights of 10 10(3) kDa. HA has many biological functio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b2390172b50de5973738d585733789f
https://pubmed.ncbi.nlm.nih.gov/21752866

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