Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Linus H. Lee"'
Autor:
Ella N. Hoogenboezem, Shrusti S. Patel, Justin H. Lo, Ashley B. Cavnar, Lauren M. Babb, Nora Francini, Eva F. Gbur, Prarthana Patil, Juan M. Colazo, Danielle L. Michell, Violeta M. Sanchez, Joshua T. McCune, Jinqi Ma, Carlisle R. DeJulius, Linus H. Lee, Jonah C. Rosch, Ryan M. Allen, Larry D. Stokes, Jordan L. Hill, Kasey C. Vickers, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract The high potential of siRNAs to silence oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, divalent lipid-conjugated siRNAs are optimized for in situ binding to albumin to improve pharmacokinetics
Externí odkaz:
https://doaj.org/article/a8ad79f8d57c45aeac75fe1a848bd947
Autor:
Craig L. Duvall, Rebecca S. Cook, Dana M. Brantley-Sieders, Samantha M. Sarett, Somtochukwu C. Dimobi, Kameron V. Kilchrist, Paula Gonzalez Ericsson, Violeta Sanchez, Donna J. Hicks, Linus H. Lee, Meghan Morrison Joly, Taylor E. Kavanaugh, Meredith A. Jackson, Shan Wang, Thomas A. Werfel
Supplemental Figures S1-9 Supplemental Figure S1 - Table of Oligos Supplemental Figures S2-5 - Scheme of chemical synthesis and characterization of polymers Supplemental Figure S6 - Basic in vitro characterization of si-NPs Supplemental Figure S7 - T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0f85d61b430296663b3ff687420dc690
https://doi.org/10.1158/0008-5472.22417482.v1
https://doi.org/10.1158/0008-5472.22417482.v1
Autor:
Craig L. Duvall, Rebecca S. Cook, Dana M. Brantley-Sieders, Samantha M. Sarett, Somtochukwu C. Dimobi, Kameron V. Kilchrist, Paula Gonzalez Ericsson, Violeta Sanchez, Donna J. Hicks, Linus H. Lee, Meghan Morrison Joly, Taylor E. Kavanaugh, Meredith A. Jackson, Shan Wang, Thomas A. Werfel
Small-molecule inhibitors of the mTORC2 kinase (torkinibs) have shown efficacy in early clinical trials. However, the torkinibs under study also inhibit the other mTOR-containing complex mTORC1. While mTORC1/mTORC2 combined inhibition may be benefici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcd5836b276f4568e4674c7ef5a94558
https://doi.org/10.1158/0008-5472.c.6509856
https://doi.org/10.1158/0008-5472.c.6509856
Autor:
Ella N. Hoogenboezem, Shrusti S. Patel, Ashley B. Cavnar, Justin H. Lo, Lauren M. Babb, Nora Francini, Prarthana Patil, Juan M. Colazo, Danielle L. Michell, Violeta M. Sanchez, Joshua T. McCune, Jinqi Ma, Carlisle R. DeJulius, Linus H. Lee, Jonah C. Rosch, Ryan M. Allen, Larry D. Stokes, Jordan L. Hill, Kasey C. Vickers, Rebecca S. Cook, Craig L. Duvall
Publikováno v:
bioRxiv
The high potential for therapeutic application of siRNAs to silence traditionally undruggable oncogenic drivers remains largely untapped due to the challenges of tumor cell delivery. Here, siRNAs were optimized forin situbinding to albumin through C1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed437d3b4e1884a99c1762f14a4e284b
https://doi.org/10.1101/2023.02.14.528574
https://doi.org/10.1101/2023.02.14.528574