Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Linsheng Zhuo"'
Autor:
Shuang Li, Yanli He, Xuelin Li, Yongxia Xiong, Yan Peng, Chengkun Wang, Linsheng Zhuo, Weifan Jiang, Xianzhou Lu, Zhen Wang
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Background: Gastric cancer is one of the cancers with wide incidence, difficult treatment and high mortality in the world, especially in Asia and Africa. In our previous work, a novel o-aminobenzamide analogue F8 was identified as an early preclinica
Externí odkaz:
https://doaj.org/article/06d5bcf3713d426d8d919bc4803a72f8
Autor:
Shouyuan Sun, Tao Shi, Yan Peng, Honghua Zhang, Linsheng Zhuo, Xue Peng, Qien Li, Manxia Wang, Shuzhi Wang, Zhen Wang
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Inspired by the crucial roles of (hetero)aryl rings in cholinesterase inhibitors and the pyrrole ring in new drug discovery, we synthesized 19 pyrrole derivatives and investigated their cholinesterase inhibitory activity. As a result, compounds 3o, 3
Externí odkaz:
https://doaj.org/article/22bf171ab4ed4ac1b5bb60af6eb4e49c
Autor:
Junbo Wu, Honghua Zhang, Yuying Wang, Gaofeng Yin, Qien Li, Linsheng Zhuo, Hongjin Chen, Zhen Wang
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
A novel class of benzyl-free and benzyl-substituted carbamylated tryptamine derivatives (CDTs) was designed and synthesized to serve as effective building blocks for the development of novel multi-target directed ligands (MTDLs) for the treatment of
Externí odkaz:
https://doaj.org/article/e0f9b6e8e19c44e1a7be95dc935740c8
Publikováno v:
iScience, Vol 23, Iss 6, Pp 101179- (2020)
Summary: Motivated by the growing demand for reducing the chemical optimization burden of H2L, we developed auto in silico ligand directing evolution (AILDE, http://chemyang.ccnu.edu.cn/ccb/server/AILDE), an efficient and general approach for the rap
Externí odkaz:
https://doaj.org/article/0094b9ece1494860b08495714d6347d3
Autor:
Yuqing Wang, Lin Long, Linsheng Zhuo, Honghua Zhang, Tian Luo, Jiedan Deng, Yuying Wang, Zhao Li, Zhen Wang, Xue Peng
Publikováno v:
European Journal of Medicinal Chemistry. 256:115420
Autor:
Zhen Wang, Yongxia Xiong, Ying Peng, Xi Zhang, Shuang Li, Yan Peng, Xue Peng, Linsheng Zhuo, Weifan Jiang
Publikováno v:
European journal of medicinal chemistry. 247
It is a well-known phenomenon that natural products can serve as powerful drug leads to generate new molecular entities with novel therapeutic utility. Evodiamine (Evo), a major alkaloid component in traditional Chinese medicine Evodiae Fructus, is c
Autor:
Jiedan Deng, Lin Long, Xue Peng, Weifan Jiang, Ying Peng, Xi Zhang, Yuting Zhao, Ying Tian, Zhen Wang, Linsheng Zhuo
Publikováno v:
European Journal of Medicinal Chemistry. 255:115366
Autor:
Honghua Zhang, Yan Peng, Linsheng Zhuo, Yuying Wang, Guo Zeng, Shuzhi Wang, Lin Long, Xuelin Li, Zhen Wang
Publikováno v:
European journal of medicinal chemistry. 242
Due to the hugely important roles of neurotransmitter acetylcholine (ACh) and amyloid-β (Aβ) in the pathogenesis of Alzheimer's disease (AD), the development of multi-target directed ligands (MTDLs) focused on cholinesterase (ChE) and Aβ becomes o
Autor:
Yuying Wang, Lin Long, Quanwei Yu, Honghua Zhang, Xuelin Li, Linsheng Zhuo, Shuzhi Wang, Zhen Wang
Publikováno v:
Journal of Molecular Structure. 1276:134804