Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Linsey Reavie"'
Autor:
Laura S. Danielson, Cynthia Liu, Marc Coussens, Iannis Aifantis, Linsey Reavie, Veronica Davalos, Sergei B. Koralov, Eva Hernando, Maryaline Coffre, Maria V. Guijarro, Sherif Ibrahim, Mireia Castillo-Martin, Carlos Cordon-Cardo
Publikováno v:
Leukemia Research. 39:335-341
The overexpression of microRNA cluster miR-17-92 has been implicated in development of solid tumors and hematological malignancies. The role of miR-17-92 in lymphomagenesis has been extensively investigated; however, because of the developmental defe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::961f914787d9a12f0c01aa4722c028f4
https://doi.org/10.1016/j.leukres.2014.12.002
https://doi.org/10.1016/j.leukres.2014.12.002
Autor:
Panagiotis Ntziachristos, Junwei Shi, Luyao Xu, Christopher R. Vakoc, Beatriz Aranda-Orgilles, Steven S. Shen, Arianne Perez-Garcia, Iannis Aifantis, Bryan King, Thomas Trimarchi, Peter Sandy, Adolfo A. Ferrando, Linsey Reavie, Jasper Mullenders
Publikováno v:
Cell. 153(7):1552-1566
SummarySequencing efforts led to the identification of somatic mutations that could affect the self-renewal and differentiation of cancer-initiating cells. One such recurrent mutation targets the binding pocket of the ubiquitin ligase Fbxw7. Missense
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862ff9edb2d6f8ec1cac03d0a890897c
Publikováno v:
Trends in Immunology. 33:357-363
Hematopoietic stem cells (HSCs) residing in the bone marrow generate mature blood cells throughout the life of the organism. This is accomplished by careful regulation of HSC activity to balance quiescence, self-renewal and differentiation. Studies o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::530b0629f28e98d21a09ae8ebb6138af
https://doi.org/10.1016/j.it.2012.01.009
https://doi.org/10.1016/j.it.2012.01.009
Autor:
Delphine Ndiaye-Lobry, Lucy A. Godley, Sherif Ibrahim, Qing Dai, Linsey Reavie, Jay P. Patel, Xinyang Zhao, Stephen D. Nimer, Maria E. Figueroa, Omar Abdel-Wahab, Aparna Vasanthakumar, Camille Lobry, Miloslav Beran, Ross L. Levine, Chuan He, Jozef Madzo, Kelly Moran-Crusio, Chun-Xiao Song, Fabiana Perna, Ari Melnick, Jiri Zavadil, Alan Shih, Iannis Aifantis, Suveg Pandey
Publikováno v:
Cancer Cell. 20(1):11-24
SummarySomatic loss-of-function mutations in the ten-eleven translocation 2 (TET2) gene occur in a significant proportion of patients with myeloid malignancies. Although there are extensive genetic data implicating TET2 mutations in myeloid transform
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07d2122a6afc6a7bfca6e3e23af23e12
Autor:
Giusy Della Gatta, Andrea L. Bredemeyer, Jiri Zavadil, Eugine Lee, Beth A. Helmink, Kelly M. Crusio, Linsey Reavie, Benjamin J. Thompson, Shannon Buckley, Iannis Aifantis, Adolfo A. Ferrando, Jie Gao, Barry P. Sleckman, Beatriz Aranda-Orgilles, Teresa Palomero
Publikováno v:
Nature immunology
Hematopoietic stem cell (HSC) differentiation is regulated by cell-intrinsic and cell-extrinsic cues. In addition to transcriptional regulation, post-translational regulation may also control HSC differentiation. To test this hypothesis, we visualize
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64866bbed6a0b890018a6ba644312a46
http://europepmc.org/articles/PMC2825759
http://europepmc.org/articles/PMC2825759
Autor:
Yevgeniy Lukyanov, Silvia Buonamici, Elizabeth W. Newcomb, Argiris Efstratiadis, Martin Lipp, Iannis Aifantis, Eric A. Gehrie, David Zagzag, Linsey Reavie, Filiz Sen, Daniel Meruelo, Mengling Li, Thomas Trimarchi, Maria Grazia Ruocco, Michael L. Dustin, Sherif Ibrahim, Brenton G. Mar, Jen-Chieh Tseng, Jonathan S. Bromberg, Jiri Zavadil, Séverine Cathelin, Apostolos Klinakis
Publikováno v:
Nature. 459:1000-1004
T-cell acute lymphoblastic leukaemia (T-ALL) is a blood malignancy afflicting mainly children and adolescents1. T-ALL patients present at diagnosis with increased white cell counts and hepatosplenomegaly, and are at an increased risk of central nervo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17f58040f502b3c6bfd7f168d1fcb852
https://doi.org/10.1038/nature08020
https://doi.org/10.1038/nature08020
Autor:
Mohamed Bentires-Alj, Duvini De Silva, Olulanu H. Aina, Linsey Reavie, Joana Pinto Couto, Tim Roloff, Hubertus Kohler, Adrian Britschgi, Tobias Eichlisberger, Robert D. Cardiff, Shany Koren, Michael B. Stadler
Publikováno v:
Nature. 525(7567)
The adult mouse mammary epithelium contains self-sustained cell lineages that form the inner luminal and outer basal cell layers, with stem and progenitor cells contributing to its proliferative and regenerative potential. A key issue in breast cance
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c712d3a5b23424207b1fe3f91b6609b
https://pubmed.ncbi.nlm.nih.gov/26266975
https://pubmed.ncbi.nlm.nih.gov/26266975
The ubiquitin-proteasome system (UPS) is a multi-subunit pathway that allows for ubiquitin modification of proteins and leads to either degradation or other non-proteolytic processes such as trafficking or transcriptional activation. Given its role a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71a789b15c7469825f87e68504c07662
https://europepmc.org/articles/PMC3651593/
https://europepmc.org/articles/PMC3651593/
Autor:
Jian-Jun Wei, Silvia Menendez, Xuanyi Zou, David Polsky, Eva Hernando, Peng Lee, Jan Zakrzewski, Dusan Bogunovic, Douglas Hanniford, Iman Osman, Amy Rose, Miguel F. Segura, Nina Bhardwaj, Silvia Alvarez-Diaz, Ilana Belitskaya-Levy, Linsey Reavie, Elen Blochin
Publikováno v:
Digital.CSIC. Repositorio Institucional del CSIC
instname
instname
The highly aggressive character of melanoma makes it an excellent model for probing the mechanisms underlying metastasis, which remains one of the most difficult challenges in treating cancer. We find that miR-182, member of a miRNA cluster in a chro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0fe7cf1d4bc4263efcd79a213b70e7e
http://hdl.handle.net/10261/78987
http://hdl.handle.net/10261/78987
Autor:
Thomas Trimarchi, Brenton G. Mar, Gwendalyn J. Randolph, Silvia Buonamici, Jonathan S. Bromberg, Iannis Aifantis, Eric A. Gehrie, Emma L. Kuan, Linsey Reavie, Apostolos Klinakis
Publikováno v:
Blood. 112:199-199
Intensive chemotherapy helps achieve remission in the vast majority of acute lymphoblastic leukemia (ALL) patients. A subset of these cases, T-cell ALL (T-ALL), fare significantly worse, presenting with more severe disease, lower remission rates and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e83a6e65e5314bc234fd4b7efbee1973
https://doi.org/10.1182/blood.v112.11.199.199
https://doi.org/10.1182/blood.v112.11.199.199